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公开(公告)号：US10738355B2
公开(公告)日：2020-08-11
申请号：US14119348
申请日：2012-05-23
申请人： Ugur Sahin , Sebastian Kreiter , Mustafa Diken , Jan Diekmann , Michael Koslowski , Cedrik Britten , John Christopher Castle , Martin Lower , Bernhard Renard , Tana Omokoko , Johannes Hendrikus De Graaf
发明人： Ugur Sahin , Sebastian Kreiter , Mustafa Diken , Jan Diekmann , Michael Koslowski , Cedrik Britten , John Christopher Castle , Martin Lower , Bernhard Renard , Tana Omokoko , Johannes Hendrikus De Graaf
IPC分类号： C12Q1/6869 , A61K39/00 , G16B20/00 , G16B40/00 , C12Q1/6886
摘要： The present invention relates to the provision of vaccines which are specific for a patient's tumor and are potentially useful for immunotherapy of the primary tumor as well as tumor metastases. In one aspect, the present invention relates to a method for providing an individualized cancer vaccine comprising the steps: (a) identifying cancer specific somatic mutations in a tumor specimen of a cancer patient to provide a cancer mutation signature of the patient; and (b) providing a vaccine featuring the cancer mutation signature obtained in step (a). In a further aspect, the present invention relates to vaccines which are obtainable by said method.
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公开(公告)号：US20140178438A1
公开(公告)日：2014-06-26
申请号：US14119348
申请日：2012-05-23
申请人： Ugur Sahin , Sebastian Kreiter , Mustafa Diken , Jan Diekmann , Michael Koslowski , Cedrik Britten , John Christopher Castle , Martin Lower , Bernhard Renard , Tana Omokoko , Johannes Hendrikus De Graaf
发明人： Ugur Sahin , Sebastian Kreiter , Mustafa Diken , Jan Diekmann , Michael Koslowski , Cedrik Britten , John Christopher Castle , Martin Lower , Bernhard Renard , Tana Omokoko , Johannes Hendrikus De Graaf
IPC分类号： C12Q1/68
摘要： The present invention relates to the provision of vaccines which are specific for a patient's tumor and are potentially useful for immunotherapy of the primary tumor as well as tumor metastases. In one aspect, the present invention relates to a method for providing an individualized cancer vaccine comprising the steps: (a) identifying cancer specific somatic mutations in a tumor specimen of a cancer patient to provide a cancer mutation signature of the patient; and (b) providing a vaccine featuring the cancer mutation signature obtained in step (a). In a further aspect, the present invention relates to vaccines which are obtainable by said method.
摘要翻译： 本发明涉及提供对患者肿瘤特异的疫苗，并且可能用于原发性肿瘤的免疫治疗以及肿瘤转移。 一方面，本发明涉及提供个体化癌症疫苗的方法，其包括以下步骤：（a）鉴定癌症患者的肿瘤标本中的癌症特异性体细胞突变，以提供患者的癌症突变特征; 和（b）提供特征在步骤（a）中获得的癌症突变特征的疫苗。 另一方面，本发明涉及可通过所述方法获得的疫苗。
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3.发明授权公开(公告)号：US09044382B2
公开(公告)日：2015-06-02
申请号：US11596649
申请日：2005-05-18
IPC分类号： A61K6/00 , C07K14/47 , C07K14/705 , C07K16/30 , C12N9/88 , G01N33/574 , A61K49/00 , A61K39/00
CPC分类号： A61K6/00 , A61K47/6851 , A61K49/00 , A61K2039/505 , C07K14/47 , C07K14/705 , C07K16/18 , C07K16/28 , C07K16/30 , C07K16/303 , C07K16/3046 , C07K16/3076 , C07K16/44 , C07K2317/24 , C07K2317/34 , C07K2317/73 , C07K2317/75 , C12N9/88 , C12Y406/01002 , G01N33/57496
摘要： According to the invention, gene products expressed in a tumor-associated manner and the nucleic acids coding therefor were identified. The invention relates to the therapy and diagnosis of diseases wherein said gene products expressed in a tumor-associated manner are aberrantly expressed. The invention also relates to proteins, polypeptides and peptides which are expressed in a tumor associated manner and to nucleic acids coding therefor.
摘要翻译： 根据本发明，鉴定了以肿瘤相关方式表达的基因产物和其编码的核酸。 本发明涉及疾病的治疗和诊断，其中以肿瘤相关方式表达的所述基因产物被异常表达。 本发明还涉及以肿瘤相关方式表达的蛋白质，多肽和肽以及编码它们的核酸。
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公开(公告)号：US08716455B2
公开(公告)日：2014-05-06
申请号：US12197960
申请日：2008-08-25
申请人： Ugur Sahin , Özlem Türeci , Michael Koslowski
发明人： Ugur Sahin , Özlem Türeci , Michael Koslowski
IPC分类号： C07K16/00
CPC分类号： C07K16/30 , A61K38/00 , A61K39/00 , A61K39/39558 , A61K48/00 , C07K14/4748 , C07K16/3015 , C07K16/3023 , C07K16/3053 , C07K16/3069 , C07K2317/34 , C07K2317/76 , C12Q1/6886 , C12Q2600/112 , C12Q2600/158 , G01N33/574
摘要： The invention relates to the identification of genetic products that are expressed in association with a tumor and the nucleic acid coding therefor. The invention relates to the therapy and diagnosis of diseases in which said genetic products that are expressed in association with a tumor are expressed in an aberrant manner. The invention also relates to proteins, polypeptides, and peptides which are expressed in association with a tumor and the nucleic acids coding therefor.
摘要翻译： 本发明涉及与肿瘤相关表达的遗传产物的鉴定及其编码的核酸。 本发明涉及以异常方式表达与肿瘤相关表达的所述遗传产物的疾病的治疗和诊断。 本发明还涉及与肿瘤相关的表达的蛋白质，多肽和肽以及编码它们的核酸。
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公开(公告)号：US20130071325A1
公开(公告)日：2013-03-21
申请号：US13636277
申请日：2011-03-10
IPC分类号： C07K16/30
CPC分类号： C07K16/30 , A61K39/39558 , A61K2039/505 , C07K16/462 , C07K16/464 , C07K2317/14 , C07K2317/34 , C07K2317/73 , C07K2317/76 , C12N5/163 , C12N15/1138 , C12N2310/14
摘要： The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing GT468, including tumor-related diseases such as breast cancer, lung cancer, gastric cancer, ovarian cancer, hepatocellular cancer, colon cancer, pancreatic cancer, esophageal cancer, head & neck cancer, kidney cancer, in particular renal cell carcinoma, prostate cancer, liver cancer, melanoma, sarcoma, myeloma, neuroblastoma, placental choriocarcinoma, cervical cancer, and thyroid cancer, and the metastatic forms thereof. In one embodiment, the tumor disease is metastatic cancer in the lung.
摘要翻译： 本发明提供了可用作治疗和/或预防与表达GT468的细胞相关的疾病的治疗剂的抗体，包括肿瘤相关疾病如乳腺癌，肺癌，胃癌，卵巢癌，肝细胞癌，结肠癌，胰腺癌，食管癌 癌症，头颈癌，肾癌，特别是肾细胞癌，前列腺癌，肝癌，黑素瘤，肉瘤，骨髓瘤，成神经细胞瘤，胎盘绒毛膜癌，子宫颈癌和甲状腺癌及其转移形式。 在一个实施方案中，肿瘤疾病是肺中的转移性癌症。
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6.发明申请公开(公告)号：US20120070430A1
公开(公告)日：2012-03-22
申请号：US13266368
申请日：2010-04-22
申请人： Ugur Sahin , Ozlem Tureci , Michael Koslowski
发明人： Ugur Sahin , Ozlem Tureci , Michael Koslowski
IPC分类号： A61K39/395 , C07K16/18 , C07K14/47 , C12N5/10 , C12N1/21 , A61P35/00 , C07H21/00 , A61K39/00 , C12Q1/68 , G01N33/53 , A61K35/12 , C07H21/04 , C12N1/19
CPC分类号： G01N33/57484 , A61K31/7088
摘要： The invention relates to genetic products the expression of which is associated with cancer diseases. The invention also relates to the therapy and diagnosis of diseases in which the genetic products are expressed or aberrantly expressed, in particular cancer diseases.
摘要翻译： 本发明涉及其表达与癌症疾病相关的遗传产物。 本发明还涉及遗传产物表达或异常表达，特别是癌症疾病的疾病的治疗和诊断。
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公开(公告)号：US20120014948A1
公开(公告)日：2012-01-19
申请号：US13184719
申请日：2011-07-18
申请人： Ugur Sahin , Özlem Türeci , Michael Koslowski
发明人： Ugur Sahin , Özlem Türeci , Michael Koslowski
IPC分类号： A61K39/395 , A61P35/00
CPC分类号： C07K16/30 , A61K38/00 , A61K39/00 , A61K39/39558 , A61K48/00 , C07K14/4748 , C07K16/3015 , C07K16/3023 , C07K16/3053 , C07K16/3069 , C07K2317/34 , C07K2317/76 , C12Q1/6886 , C12Q2600/112 , C12Q2600/158 , G01N33/574
摘要： The invention relates to the identification of genetic products that are expressed in association with a tumor and the nucleic acid coding therefor. The invention relates to the therapy and diagnosis of diseases in which the genetic products that are expressed in association with a tumor are expressed in an aberrant manner. The invention also relates to proteins, polypeptides, and peptides which are expressed in association with a tumor and the nucleic acids coding therefor.
摘要翻译： 本发明涉及与肿瘤相关表达的遗传产物的鉴定及其编码的核酸。 本发明涉及以异常方式表达与肿瘤相关表达的遗传产物的疾病的治疗和诊断。 本发明还涉及与肿瘤相关的表达的蛋白质，多肽和肽以及编码它们的核酸。
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公开(公告)号：US08088913B2
公开(公告)日：2012-01-03
申请号：US12096216
申请日：2006-12-07
申请人： Ugur Sahin , Özlem Türeci , Michael Koslowski
发明人： Ugur Sahin , Özlem Türeci , Michael Koslowski
CPC分类号： C12N15/1138 , C07K14/4748 , C12N15/1137 , C12N2310/14 , C12Y301/03048
摘要： The present invention is directed to siRNA molecules which specifically target and cause RNAi-induced degradation of mRNA from TPTE genes, so that the protein product of the TPTE gene is not produced or is produced in reduced amounts. The siRNA compounds and compositions of the invention are useful for treating diseases which require inhibition of TPTE expression for their treatment, in particular cancer pathologies. The present invention also includes methods which make possible to assess and/or prognose the metastatic behavior of a cancer disease and/or the occurrence of a relapse of cancer.
摘要翻译： 本发明涉及特异性靶向并引起来自TPTE基因的mRNA的RNAi诱导的降解的siRNA分子，使得TPTE基因的蛋白质产物不产生或以减少的量产生。 本发明的siRNA化合物和组合物可用于治疗需要抑制TPTE表达以治疗，特别是癌症病症的疾病。 本发明还包括使得有可能评估和/或预测癌症疾病的转移行为和/或癌症复发的方法。
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9.发明申请Methods Involving MS4A12 and Agents Targeting MS4A12 for Therapy, Diagnosis and Testing 审中-公开涉及MS4A12和靶向MS4A12的药物用于治疗，诊断和测试的方法公开(公告)号：US20110027297A1
公开(公告)日：2011-02-03
申请号：US12937178
申请日：2009-03-30
申请人： Ugur Sahin , Ozlem Tureci , Michael Koslowski
发明人： Ugur Sahin , Ozlem Tureci , Michael Koslowski
IPC分类号： A61K39/395 , C07H21/02 , C07H21/00 , C07K16/28 , A61K31/713 , A61K31/7088 , C12N5/071 , C12Q1/68 , C12Q1/02 , G01N33/566 , A61P35/00 , A61P35/04
CPC分类号： C12N15/1138 , A61K2039/505 , C12N2310/11 , C12N2310/111 , C12N2310/14 , G01N33/5011 , G01N33/57419 , G01N2333/485 , G01N2333/70596
摘要： The invention relates to methods involving MS4A12 and agents targeting MS4A12 which are useful for therapy, diagnosis and testing of disease states, in particular cancer diseases. In particular, the invention relates to agents which reduce or inhibit expression or activity of MS4A12, compositions containing these agents, and methods for reducing, determining, or increasing the responsiveness of a cell towards EGF.
摘要翻译： 本发明涉及涉及MS4A12和靶向MS4A12的试剂的方法，其可用于治疗，诊断和测试疾病状态，特别是癌症疾病。 特别地，本发明涉及减少或抑制MS4A12的表达或活性，含有这些试剂的组合物以及减少，测定或增加细胞对EGF的反应性的方法。
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10.发明申请Compositions and Methods for Therapy and Diagnosis of Cancer and Cancer Metastasis 审中-公开癌症和癌症转移治疗和诊断的组合和方法公开(公告)号：US20090253775A1
公开(公告)日：2009-10-08
申请号：US12420612
申请日：2009-04-08
申请人： Ugur Sahin , Ozlem Tureci , Michael Koslowski
发明人： Ugur Sahin , Ozlem Tureci , Michael Koslowski
IPC分类号： A61K31/7088 , G01N33/53 , C12Q1/68 , A61P35/00
CPC分类号： C12Q1/6886 , A61K31/7088 , A61K39/39558 , A61K47/6807 , C07K16/28 , C07K16/2866 , C07K16/40 , C07K2317/76 , C12N15/1138 , C12N15/8218 , C12N2310/11 , C12N2310/14 , C12Q2600/118 , C12Q2600/154 , C12Q2600/158 , G01N33/57484 , G01N33/57492 , G01N2333/715 , G01N2333/7158 , G01N2333/916
摘要： The present invention relates to methods which make possible to assess and/or prognose a cancer disease, the metastatic behaviour of a cancer disease and/or the occurrence of a relapse of cancer. In particular, the methods of the invention make possible to assess and/or prognose the occurrence of cancer metastasis, in particular distant metastasis. Preferably, the methods of the invention allow to discriminate malign from benign conditions.
摘要翻译： 本发明涉及有可能评估和/或预测癌症疾病，癌症疾病的转移行为和/或癌症复发的方法。 特别地，本发明的方法使得有可能评估和/或预测癌症转移的发生，特别是远处转移。 优选地，本发明的方法允许区分恶性与良性状况。
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