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    Mitigation of biomolecular adsorption with hydrophilic polymer additives
    1.
    发明授权
    Mitigation of biomolecular adsorption with hydrophilic polymer additives 有权
    用亲水性聚合物添加剂缓解生物分子吸附

    公开(公告)号：US08481125B2

    公开(公告)日：2013-07-09

    申请号：US11915308

    申请日：2006-05-18

    申请人： Uichong B. Yi ,  Peter-Patrick De Guzman ,  Wayne Po-Wen Liu

    发明人： Uichong B. Yi ,  Peter-Patrick De Guzman ,  Wayne Po-Wen Liu

    IPC分类号： B05D3/10

    CPC分类号： B01L3/502792 ,  B01J2219/00837 ,  B01L2200/12 ,  B01L2300/0816 ,  B01L2300/089 ,  B01L2300/165 ,  B01L2400/0418 ,  B01L2400/0421 ,  B01L2400/0424 ,  B01L2400/0427 ,  Y10T428/139

    摘要： Molecular adsorption to the microfluidic device surfaces can be passively and actively mitigated by mixing certain hydrophilic polymers (organic polymers with repeating hydrophilic groups—the preferred polymers being amphipathic surfactants—with the sample liquid during or prior to relevant microfluidic operations. Nonionic surfactants such as polyoxyethylene sorbitan monooleate and polyoxyethylene octyl phenyl ether are especially effective. High molecular weight polyethylene polymers are also effective. The hydrophilic polymers appear to prevent binding of the fouling molecules to the microfluidic by occupying the surface sites in place of the fouling molecules or by interacting with the fouling molecules to prevent binding of the fouling molecules the surface. When surface adsorption is thus mitigated, microfluidic devices can readily handle samples containing biomolecules to enable active sample concentration, filtering, washing, transport, mixing and other sample handling operations.

    摘要翻译： 通过将某些亲水性聚合物（具有重复亲水基团的有机聚合物 - 优选的两亲性表面活性剂聚合物 - 与相关微流控操作期间或之前的样品液体）混合，可以对微流体装置表面进行分子吸附，非离子表面活性剂如聚氧乙烯 脱水山梨糖醇单油酸酯和聚氧乙烯辛基苯基醚是特别有效的，高分子量聚乙烯聚合物也是有效的。亲水性聚合物似乎通过占据表面位置代替结垢分子或通过与污染分子相互作用而阻止污染分子与微流体结合 污染分子以防止污垢分子与表面的结合，当表面吸附因此减轻时，微流体装置可以容易地处理含有生物分子的样品，以使活性样品浓度，过滤，洗涤，运输，混合和其他样品处理操作 ns。

    Mitigation of Biomolecular Adsorption with Hydrophilic Polymer Additives
    3.
    发明申请
    Mitigation of Biomolecular Adsorption with Hydrophilic Polymer Additives 有权
    用亲水性聚合物添加剂减缓生物分子吸附

    公开(公告)号：US20090280251A1

    公开(公告)日：2009-11-12

    申请号：US11915308

    申请日：2006-05-18

    申请人： Peter-Patrick De Guzman ,  Wayne Po-Wen Liu ,  Brandon Uichong Yi

    发明人： Peter-Patrick De Guzman ,  Wayne Po-Wen Liu ,  Brandon Uichong Yi

    IPC分类号： B05D3/00

    CPC分类号： B01L3/502792 ,  B01J2219/00837 ,  B01L2200/12 ,  B01L2300/0816 ,  B01L2300/089 ,  B01L2300/165 ,  B01L2400/0418 ,  B01L2400/0421 ,  B01L2400/0424 ,  B01L2400/0427 ,  Y10T428/139

    摘要： Molecular adsorption to the microfluidic device surfaces can be passively and actively mitigated by mixing certain hydrophilic polymers (organic polymers with repeating hydrophilic groups—the preferred polymers being amphipathic surfactants—with the sample liquid during or prior to relevant microfluidic operations. Nonionic surfactants such as polyoxyethylene sorbitan monooleate and polyoxyethylene octyl phenyl ether are especially effective. High molecular weight polyethylene polymers are also effective. The hydrophilic polymers appear to prevent binding of the fouling molecules to the microfluidic by occupying the surface sites in place of the fouling molecules or by interacting with the fouling molecules to prevent binding of the fouling molecules the surface. When surface adsorption is thus mitigated, microfluidic devices can readily handle samples containing biomolecules to enable active sample concentration, filtering, washing, transport, mixing and other sample handling operations.

    摘要翻译： 通过将某些亲水性聚合物（具有重复亲水基团的有机聚合物 - 优选的两亲性表面活性剂聚合物 - 与相关微流控操作期间或之前的样品液体）混合，可以对微流体装置表面进行分子吸附，非离子表面活性剂如聚氧乙烯 脱水山梨糖醇单油酸酯和聚氧乙烯辛基苯基醚是特别有效的，高分子量聚乙烯聚合物也是有效的。亲水性聚合物似乎通过占据表面位置代替结垢分子或通过与污染分子相互作用而阻止污染分子与微流体结合 污染分子以防止污垢分子与表面的结合，当表面吸附因此减轻时，微流体装置可以容易地处理含有生物分子的样品，以使活性样品浓度，过滤，洗涤，运输，混合和其他样品处理操作 ns。

    REMOTELY CONTROLLED REAL-TIME AND VIRTUAL LAB EXPERIMENTATION SYSTEMS AND METHODS
    7.
    发明申请
    REMOTELY CONTROLLED REAL-TIME AND VIRTUAL LAB EXPERIMENTATION SYSTEMS AND METHODS 审中-公开
    远程控制实时和虚拟实验室实验系统和方法

    公开(公告)号：US20080215705A1

    公开(公告)日：2008-09-04

    申请号：US12027989

    申请日：2008-02-07

    申请人： Wayne Po-Wen Liu ,  Peter Patrick DeGuzman ,  Uichong Brandon Yi

    发明人： Wayne Po-Wen Liu ,  Peter Patrick DeGuzman ,  Uichong Brandon Yi

    IPC分类号： G06F15/16

    CPC分类号： G06Q10/10

    摘要： Remotely controlled platforms for experimentation provide for centralized placement of costly and space consuming experimentation equipment. Additionally, remotely controlled platforms take advantage of economies of scale to make the centralized experimentation platforms more available for students and researchers of institutions that cannot afford to have institutional ownership of the experimentation platforms.

    摘要翻译： 用于实验的远程控制平台提供了昂贵且耗费空间的实验设备的集中放置。 此外，远程控制平台利用规模经济，使集权实验平台更易于为无法承担实验平台机构所有权的机构的学生和研究人员提供。