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    Methods and Compositions for PDGF-C Activation and Inhibition
    5.
    发明申请
    Methods and Compositions for PDGF-C Activation and Inhibition 审中-公开
    PDGF-C激活和抑制的方法和组合

    公开(公告)号：US20100221254A1

    公开(公告)日：2010-09-02

    申请号：US12652998

    申请日：2010-01-06

    申请人： Linda Fredriksson ,  Hong Li ,  Christina Fieber ,  Xuri Li ,  Ulf Eriksson

    发明人： Linda Fredriksson ,  Hong Li ,  Christina Fieber ,  Xuri Li ,  Ulf Eriksson

    IPC分类号： A61K39/395 ,  C07K16/00 ,  A61P35/00 ,  A61P9/10

    CPC分类号： C07K16/22 ,  A61K2039/505 ,  C07K14/49 ,  C07K14/8132 ,  C07K16/40 ,  C12N9/6459 ,  C12N9/99 ,  C12Y304/21069

    摘要： Methods for inhibiting angiogenesis comprising administering tissue-plasminogen activator (tPA) inhibitors, and pharmaceutical compositions suitable for the methods comprising the tPA inhibitors. Also provided are methods for stimulating angiogenesis comprising administering tPA to a patient in need thereof, and pharmaceutical compositions comprising an effective amount of tPA for the methods of stimulation. The present invention discloses that tPA is a specific PDGF-C activating protease, and that the CUB-domains in PDGF-CC directly interact with the protease, are required for efficient proteolysis, and released CUB-domains are tPA inhibitors. Preferably, the method and compositions of the present invention are used for simultaneously stimulating, or simultaneously inhibiting, thrombolysis and angiogenesis.

    摘要翻译： 抑制血管发生的方法包括施用组织纤溶酶原激活剂（tPA）抑制剂和适用于包含tPA抑制剂的方法的药物组合物。 还提供了用于刺激血管生成的方法，其包括向有需要的患者施用tPA，以及包含用于刺激方法的有效量的tPA的药物组合物。 本发明公开了tPA是特异性PDGF-C活化蛋白酶，PDGF-CC中的CUB结构域与蛋白酶直接相互作用，是有效的蛋白水解所必需的，而释放的CUB结构域是tPA抑制剂。 优选地，本发明的方法和组合物用于同时刺激或同时抑制溶栓和血管发生。

    Methods and compositions for PDGF-C activation and inhibition
    6.
    发明申请
    Methods and compositions for PDGF-C activation and inhibition 审中-公开
    用于PDGF-C活化和抑制的方法和组合物

    公开(公告)号：US20090047284A1

    公开(公告)日：2009-02-19

    申请号：US11985984

    申请日：2007-11-19

    申请人： Linda Fredriksson ,  Hong Li ,  Christina Fieber ,  Xuri Li ,  Ulf Eriksson

    发明人： Linda Fredriksson ,  Hong Li ,  Christina Fieber ,  Xuri Li ,  Ulf Eriksson

    IPC分类号： A61K39/395 ,  A61K38/48 ,  C07K16/18 ,  A61P7/00

    CPC分类号： C07K16/22 ,  A61K2039/505 ,  C07K14/49 ,  C07K14/8132 ,  C07K16/40 ,  C12N9/6459 ,  C12N9/99 ,  C12Y304/21069

    摘要： Methods for inhibiting angiogenesis comprising administering tissue-plasminogen activator (tPA) inhibitors, and pharmaceutical compositions suitable for the methods comprising the tPA inhibitors. Also provided are methods for stimulating angiogenesis comprising administering tPA to a patient in need thereof, and pharmaceutical compositions comprising an effective amount of tPA for the methods of stimulation. The present invention discloses that tPA is a specific PDGF-C activating protease, and that the CUB-domains in PDGF-CC directly interact with the protease, are required for efficient proteolysis, and released CUB-domains are tPA inhibitors. Preferably, the method and compositions of the present invention are used for simultaneously stimulating, or simultaneously inhibiting, thrombolysis and angiogenesis.

    摘要翻译： 抑制血管发生的方法包括施用组织纤溶酶原激活剂（tPA）抑制剂和适用于包含tPA抑制剂的方法的药物组合物。 还提供了用于刺激血管生成的方法，其包括向有需要的患者施用tPA，以及包含用于刺激方法的有效量的tPA的药物组合物。 本发明公开了tPA是特异性PDGF-C活化蛋白酶，PDGF-CC中的CUB结构域与蛋白酶直接相互作用，是有效的蛋白水解所必需的，而释放的CUB结构域是tPA抑制剂。 优选地，本发明的方法和组合物用于同时刺激或同时抑制溶栓和血管发生。

    Pre-Heater For An Apparatus For The Production Of Carbon Black
    9.
    发明申请
    Pre-Heater For An Apparatus For The Production Of Carbon Black 审中-公开
    用于生产炭黑的设备的预热器

    公开(公告)号：US20090107660A1

    公开(公告)日：2009-04-30

    申请号：US11791614

    申请日：2005-10-12

    申请人： Ulf Eriksson ,  Fredrik Dahlstedt

    发明人： Ulf Eriksson ,  Fredrik Dahlstedt

    IPC分类号： F28D7/00

    CPC分类号： C09C1/48 ,  F28D7/16 ,  F28F9/007 ,  F28F2265/26

    摘要： A pre-heater for an apparatus for the production of carbon black, is adapted to pre-heat air by heat exchange to a temperature of at least 800° C., comprises an elongated jacket arranged substantially and having a top end and a bottom end, said jacket defining a space, a plurality of tubings arranged inside said space, said tubings having a diameter of 85 to 90 mm, said jacket being provided with an air inlet and an air outlet, for allowing said air to enter and exit said space, a smoke inlet chamber and a smoke collection chamber for allowing smoke to enter and exit said tubing. Said jacket is supported by a suspension means between said top and bottom ends excluding at the top end as such, such that the jacket is allowed to expand upwards above and downwards below said suspension means.

    摘要翻译： 用于生产炭黑的设备的预热器适于通过热交换将空气预热至至少800℃的温度，包括基本上设置有顶端和底端的细长护套 所述护套限定空间，多个管道布置在所述空间内，所述管道具有85至90mm的直径，所述护套设置有空气入口和空气出口，用于允许所述空气进入和离开所述空间 烟雾入口室和烟雾收集室，用于允许烟雾进入和离开所述管道。 所述护套由顶部和底部端部之间的顶端和底端之间的悬挂装置支撑，从而允许外套在所述悬挂装置下方向上和向下扩展。

    Antibodies to PDGF-D
    10.
    发明申请
    Antibodies to PDGF-D 审中-公开

    公开(公告)号：US20080261888A1

    公开(公告)日：2008-10-23

    申请号：US12148656

    申请日：2008-04-21

    申请人： Marko Uutela ,  Ulf Eriksson ,  Kari Alitalo

    发明人： Marko Uutela ,  Ulf Eriksson ,  Kari Alitalo

    IPC分类号： A61K38/00 ,  C12N5/06 ,  A61P43/00

    CPC分类号： C07K14/49 ,  A61K38/00 ,  C07K16/22 ,  C12Q1/6886 ,  C12Q2600/158

    摘要： PDGF-D, a new member of the PDGF/VEGF family of growth factors, as well as the nucleotide sequence encoding it, methods for producing it, antibodies and other antagonists to it, transfected and transformed host cells expressing it, pharmaceutical compositions containing it, and uses thereof in medical and diagnostic applications, including methods for stimulating growth of a connective tissue or healing a wound in a mammal, which methods comprise administering to the mammal an effective amount of PDGF-D polypeptides or polynucleotides encoding the PDGF-D polypeptides.