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    Antibodies to PDGF-D
    4.
    发明授权
    Antibodies to PDGF-D 失效
    PDGF-D抗体

    公开(公告)号：US07408040B2

    公开(公告)日：2008-08-05

    申请号：US11140284

    申请日：2005-05-31

    申请人： Marko Uutela ,  Ulf Eriksson ,  Kari Alitalo

    发明人： Marko Uutela ,  Ulf Eriksson ,  Kari Alitalo

    IPC分类号： C07K16/00

    CPC分类号： C07K14/49 ,  A61K38/00 ,  C07K16/22 ,  C12Q1/6886 ,  C12Q2600/158

    摘要： PDGF-D, a new member of the PDGF/VEGF family of growth factors, as well as the nucleotide sequence encoding it, methods for producing it, antibodies and other antagonists to it, transfected and transformed host cells expressing it, pharmaceutical compositions containing it, and uses thereof in medical and diagnostic applications, including methods for stimulating growth of a connective tissue or healing a wound in a mammal, which methods comprise administering to the mammal an effective amount of PDGF-D polypeptides or polynucleotides encoding the PDGF-D polypeptides.

    摘要翻译： PDGF-D，PDGF / VEGF家族生长因子的新成员，以及编码它的核苷酸序列，其生产方法，抗体和其它拮抗剂，转染和转化的表达它的宿主细胞，含有它的药物组合物 以及其在医学和诊断应用中的应用，包括刺激结缔组织生长或愈合哺乳动物伤口的方法，该方法包括向哺乳动物施用有效量的PDGF-D多肽或编码PDGF-D多肽的多核苷酸 。

    Method for modulating, regulating and/or stabilizing angiogenesis
    5.
    发明申请
    Method for modulating, regulating and/or stabilizing angiogenesis 审中-公开

    公开(公告)号：US20090202491A1

    公开(公告)日：2009-08-13

    申请号：US12315893

    申请日：2008-12-08

    申请人： Ulf Eriksson ,  Kari Alitalo ,  Marko Uutela

    发明人： Ulf Eriksson ,  Kari Alitalo ,  Marko Uutela

    IPC分类号： A61K48/00 ,  A61K31/7052 ,  A61P9/00

    CPC分类号： A61K38/1858 ,  A61K48/00

    摘要： A method of modulating, regulating and/or stabilizing angiogenesis in a mammal in need thereof, in which the PDGF-D level or activity or both in the mammal are modulated or increased. In preferred embodiments, an active PDGF-D polypeptide, or a polynucleotide encoding an active PDGF-D is administered to the mammal, preferably at a location where angiogenesis modulation or stabilization is desired. The PDGF-D is advantageously co-administered with an angiogenic growth factor, such as a member of the VEGF family of growth factors, in particular VEGF-E. The claimed method inhibits leakage of blood vessels and is useful, inter alia, for treatment of edemas.

    Antibosies to PDGF-D
    7.
    发明申请
    Antibosies to PDGF-D 失效
    抗PDGF-D抗体

    公开(公告)号：US20060030695A1

    公开(公告)日：2006-02-09

    申请号：US11140284

    申请日：2005-05-31

    申请人： Marko Uutela ,  Ulf Eriksson ,  Kari Alitalo

    发明人： Marko Uutela ,  Ulf Eriksson ,  Kari Alitalo

    IPC分类号： A61K39/395 ,  C07K16/28

    CPC分类号： C07K14/49 ,  A61K38/00 ,  C07K16/22 ,  C12Q1/6886 ,  C12Q2600/158

    摘要： PDGF-D, a new member of the PDGF/VEGF family of growth factors, as well as the nucleotide sequence encoding it, methods for producing it, antibodies and other antagonists to it, transfected and transformed host cells expressing it, pharmaceutical compositions containing it, and uses thereof in medical and diagnostic applications, including methods for stimulating growth of a connective tissue or healing a wound in a mammal, which methods comprise administering to the mammal an effective amount of PDGF-D polypeptides or polynucleotides encoding the PDGF-D polypeptides.

    摘要翻译： PDGF-D，PDGF / VEGF家族生长因子的新成员，以及编码它的核苷酸序列，其生产方法，抗体和其它拮抗剂，转染和转化的表达它的宿主细胞，含有它的药物组合物 以及其在医学和诊断应用中的应用，包括刺激结缔组织生长或愈合哺乳动物伤口的方法，该方法包括向哺乳动物施用有效量的PDGF-D多肽或编码PDGF-D多肽的多核苷酸 。

    Antibodies to PDGF-D
    8.
    发明申请
    Antibodies to PDGF-D 审中-公开

    公开(公告)号：US20080261888A1

    公开(公告)日：2008-10-23

    申请号：US12148656

    申请日：2008-04-21

    申请人： Marko Uutela ,  Ulf Eriksson ,  Kari Alitalo

    发明人： Marko Uutela ,  Ulf Eriksson ,  Kari Alitalo

    IPC分类号： A61K38/00 ,  C12N5/06 ,  A61P43/00

    CPC分类号： C07K14/49 ,  A61K38/00 ,  C07K16/22 ,  C12Q1/6886 ,  C12Q2600/158

    摘要： PDGF-D, a new member of the PDGF/VEGF family of growth factors, as well as the nucleotide sequence encoding it, methods for producing it, antibodies and other antagonists to it, transfected and transformed host cells expressing it, pharmaceutical compositions containing it, and uses thereof in medical and diagnostic applications, including methods for stimulating growth of a connective tissue or healing a wound in a mammal, which methods comprise administering to the mammal an effective amount of PDGF-D polypeptides or polynucleotides encoding the PDGF-D polypeptides.

    Method for stimulating connective tissue growth or wound healing
    9.
    发明申请
    Method for stimulating connective tissue growth or wound healing 审中-公开
    刺激结缔组织生长或伤口愈合的方法

    公开(公告)号：US20050209136A1

    公开(公告)日：2005-09-22

    申请号：US10794392

    申请日：2004-03-08

    申请人： Ulf Eriksson ,  Marko Uutela ,  Kari Alitalo

    发明人： Ulf Eriksson ,  Marko Uutela ,  Kari Alitalo

    IPC分类号： A61K38/18 ,  C07K14/49

    CPC分类号： C07K14/49 ,  A61K38/1858

    摘要： PDGF-D, a new member of the PDGFVEGF family of growth factors, as well as the nucleotide sequence encoding it, methods for producing it, antibodies and other antagonists to it, transfected and transformed host cells expressing it, pharmaceutical compositions containing it, and uses thereof in medical and diagnostic applications, including methods for stimulating growth of a connective tissue or healing a wound in a mammal, which methods comprise administering to the mammal an effective amount of PDGF-D polypeptides or polynucleotides encoding the PDGF-D polypeptides.

    摘要翻译： PDGF-D，PDGFVEGF家族生长因子的新成员，以及编码它的核苷酸序列，其生产方法，抗体和其它拮抗剂，转染和转化的表达它的宿主细胞，含有它的药物组合物和 其用于医学和诊断应用，包括刺激结缔组织生长或愈合哺乳动物伤口的方法，该方法包括向哺乳动物施用有效量的PDGF-D多肽或编码PDGF-D多肽的多核苷酸。

    Method for modulating, regulating and/or stabilizing angiogenesis
    10.
    发明授权
    Method for modulating, regulating and/or stabilizing angiogenesis 失效
    调节，调节和/或稳定血管发生的方法

    公开(公告)号：US07476654B2

    公开(公告)日：2009-01-13

    申请号：US11073605

    申请日：2005-03-08

    申请人： Kari Alitalo ,  Ulf Eriksson ,  Marko Uutela

    发明人： Kari Alitalo ,  Ulf Eriksson ,  Marko Uutela

    IPC分类号： A61K38/18

    CPC分类号： A61K38/1858 ,  A61K48/00

    摘要： A method of modulating, regulating and/or stabilizing angiogenesis in a mammal in need thereof, in which the PDGF-D level or activity or both in the mammal are modulated or increased. In preferred embodiments, an active PDGF-D polypeptide, or a polynucleotide encoding an active PDGF-D is administered to the mammal, preferably at a location where angiogenesis modulation or stabilization is desired. The PDGF-D is advantageously co-administered with an angiogenic growth factor, such as a member of the VEGF family of growth factors, in particular VEGF-E. The claimed method inhibits leakage of blood vessels and is useful, inter alia, for treatment of edemas.

    摘要翻译： 在有需要的哺乳动物中调节，调节和/或稳定血管发生的方法，其中调节或增加哺乳动物的PDGF-D水平或活性。 在优选的实施方案中，将活性PDGF-D多肽或编码活性PDGF-D的多核苷酸施用于哺乳动物，优选在需要血管生成调节或稳定的位置。 PDGF-D有利地与血管生成生长因子如生长因子VEGF家族的成员，特别是VEGF-E共同施用。 所要求保护的方法抑制血管渗漏，尤其用于治疗水肿。