公开(公告)号：US20210299056A9

公开(公告)日：2021-09-30

申请号：US12467229

申请日：2009-05-15

申请人： Ulf Fritz ,  Olaf Fritz ,  Thomas A. Gordy ,  Ronald Wojcik ,  Jacques BLÜMMEL ,  Alexander KÜLLER

发明人： Ulf Fritz ,  Olaf Fritz ,  Thomas A. Gordy ,  Ronald Wojcik ,  Jacques BLÜMMEL ,  Alexander KÜLLER

IPC分类号： A61K9/50 ,  A61K47/32 ,  A61K47/34 ,  A61K49/04 ,  A61K49/18 ,  A61K49/22 ,  A61M5/00

摘要： Various embodiments are directed to color-coded and size-calibrated polymeric particles comprising an acrylate-based hydrogel core incorporating one or more chromophores of interest, and an outer shell comprising polyphosphazenes of formula I, useful for various therapeutic and/or diagnostic procedures. In various embodiments, the color-coded and size-calibrated polymeric particles can be employed in any particle-mediated procedure, including as embolic agents, dermal fillers, and various implantable devices for a broad range of clinical and cosmetic applications. The incorporation of a particular chromophore formulation that correlates with a pre-determined size specificity for implantable and loadable polymeric particles (“color-coded and size-calibrated”) enables the visual detection and identification of particles exhibiting a particular size of interest, and minimizes the probability of user-introduced or procedural errors.

公开(公告)号：US20100028260A1

公开(公告)日：2010-02-04

申请号：US12467229

申请日：2009-05-15

申请人： Ulf Fritz ,  Olaf Fritz ,  Thomas A. Gordy ,  Ronald Wojcik ,  Jacques BLÜMMEL ,  Alexander KÜLLER

发明人： Ulf Fritz ,  Olaf Fritz ,  Thomas A. Gordy ,  Ronald Wojcik ,  Jacques BLÜMMEL ,  Alexander KÜLLER

IPC分类号： A61K9/14 ,  A61K49/00 ,  A61K47/34 ,  A61K48/00

摘要： Various embodiments are directed to color-coded and size-calibrated polymeric particles comprising an acrylate-based hydrogel core incorporating one or more chromophores of interest, and an outer shell comprising polyphosphazenes of formula I, useful for various therapeutic and/or diagnostic procedures. In various embodiments, the color-coded and size-calibrated polymeric particles can be employed in any particle-mediated procedure, including as embolic agents, dermal fillers, and various implantable devices for a broad range of clinical and cosmetic applications. The incorporation of a particular chromophore formulation that correlates with a pre-determined size specificity for implantable and loadable polymeric particles (“color-coded and size-calibrated”) enables the visual detection and identification of particles exhibiting a particular size of interest, and minimizes the probability of user-introduced or procedural errors.

摘要翻译： 各种实施方案涉及颜色编码和尺寸校准的聚合物颗粒，其包含掺入一种或多种感兴趣发色团的基于丙烯酸酯的水凝胶核心，以及包含式I聚磷腈的外壳，其可用于各种治疗和/或诊断程序。 在各种实施方案中，颜色编码和尺寸校准的聚合物颗粒可以用于任何颗粒介导的过程，包括作为栓塞剂，皮肤填充剂和用于广泛临床和化妆品应用的各种可植入装置。 结合与可植入和可加载的聚合物颗粒的预定尺寸特异性相关的特定发色团配方（“经颜色编码和尺寸校准”）使得能够目视检测和鉴定表现出特定感兴趣尺寸的颗粒，并且最小化 用户引入或程序错误的概率。