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1.发明申请Methods of identification of novel ligands for modulation of orphan nuclear receptor RAR-related orphan receptor-gamma (NR1F3) activity 审中-公开鉴定用于调节孤儿核受体RAR相关孤儿受体-γ（NR1F3）活性的新配体的方法公开(公告)号：US20110263046A1
公开(公告)日：2011-10-27
申请号：US13124860
申请日：2009-10-28
申请人： Ulrich Deuschle , Ulrich Abel , Claus Kremoser , Thomas Schlueter , Thomas Hoffmann , Sanja Perovic-Ottstadt
发明人： Ulrich Deuschle , Ulrich Abel , Claus Kremoser , Thomas Schlueter , Thomas Hoffmann , Sanja Perovic-Ottstadt
IPC分类号： G01N33/566
CPC分类号： A61K31/575 , A61K31/192 , A61K31/551 , G01N33/542 , G01N33/6875 , G01N2333/70567 , G01N2500/00
摘要： The invention relates to modulators for the orphan nuclear receptor RORgamma and methods for identification and screening of novel modulators for RORgamma activity as well as methods for treating RORgamma mediated diseases with novel RORgamma modulators identified by such methods.
摘要翻译： 本发明涉及用于孤儿核受体RORγ的调节剂和用于鉴定和筛选用于RORGAMMA活性的新型调节剂的方法以及通过这些方法鉴定的新型RORγ调节剂治疗RORGAMMA介导的疾病的方法。
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公开(公告)号：US20100184809A1
公开(公告)日：2010-07-22
申请号：US12376482
申请日：2007-08-29
申请人： Claus Kremoser , Ulrich Deuschle , Ulrich Abel , Andreas Schulz
发明人： Claus Kremoser , Ulrich Deuschle , Ulrich Abel , Andreas Schulz
IPC分类号： A61K31/4439 , C07D413/12 , A61P3/10 , A61P1/16 , A61P3/06 , A61P9/10 , A61P13/12 , A61P25/02 , A61P7/02 , A61P31/06 , A61P31/08 , A61P33/02 , A61P13/08 , A61P35/00
CPC分类号： C07D413/12 , C07D401/06 , C07D401/12 , C07D413/14
摘要： The present invention relates to compounds which bind to the NR1H4 receptor (FXR) and act as agonists or partial agonists of the NR1H4 receptor (FXR). The invention further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of said nuclear receptor by said compounds, and to a process for the synthesis of said compounds.
摘要翻译： 本发明涉及结合NR1H4受体（FXR）并作为NR1H4受体（FXR）的激动剂或部分激动剂的化合物。 本发明还涉及该化合物在制备用于通过所述化合物与所述核受体结合来治疗疾病和/或病症的药物的用途，以及合成所述化合物的方法中的用途。
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公开(公告)号：US08193192B2
公开(公告)日：2012-06-05
申请号：US12377307
申请日：2007-08-29
申请人： Claus Kremoser , Ulrich Deuschle , Ulrich Abel , Andreas Schulz
发明人： Claus Kremoser , Ulrich Deuschle , Ulrich Abel , Andreas Schulz
IPC分类号： A61K31/50 , A61K31/501 , A61K31/497 , C07D413/00 , C07D401/00 , C07D403/00 , C07D405/00 , C07D409/00
CPC分类号： C07D413/12
摘要： The present invention relates to compounds which bind to the NR1H4 receptor (FXR) and act as agonists or partial agonists of the NR1H4 receptor (FXR). The invention further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of said nuclear receptor by said compounds, and to a process for the synthesis of said compounds.
摘要翻译： 本发明涉及结合NR1H4受体（FXR）并作为NR1H4受体（FXR）的激动剂或部分激动剂的化合物。 本发明还涉及该化合物在制备用于通过所述化合物与所述核受体结合来治疗疾病和/或病症的药物的用途，以及合成所述化合物的方法中的用途。
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公开(公告)号：US20100210660A1
公开(公告)日：2010-08-19
申请号：US12377307
申请日：2007-08-29
申请人： Claus Kremoser , Ulrich Deuschle , Ulrich Abel , Andreas Schulz
发明人： Claus Kremoser , Ulrich Deuschle , Ulrich Abel , Andreas Schulz
IPC分类号： A61K31/4439 , C07D413/12 , A61K31/501 , A61P1/16 , A61P29/00 , A61P3/06 , A61P3/10 , A61P9/00 , A61P35/00
CPC分类号： C07D413/12
摘要： The present invention relates to compounds which bind to the NRI H4 receptor (FXR) and act as agonists or partial agonists of the NR1 H4 receptor (FXR). The invention further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of said nuclear receptor by said compounds, and to a process for the synthesis of said compounds.
摘要翻译： 本发明涉及结合NRI H4受体（FXR）并作为NR1H4受体（FXR）的激动剂或部分激动剂的化合物。 本发明还涉及该化合物在制备用于通过所述化合物与所述核受体结合来治疗疾病和/或病症的药物的用途，以及合成所述化合物的方法中的用途。
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5.发明申请Novel 2-amino-4-quinazolinones and 2-amino-4-oxoquinazolones as LXR nuclear receptor binding compounds with partial agonistic properties 审中-公开新型2-氨基-4-喹唑啉酮和2-氨基-4-氧代喹唑啉酮作为具有部分激动性的LXR核受体结合化合物公开(公告)号：US20050261319A1
公开(公告)日：2005-11-24
申请号：US11076163
申请日：2005-03-09
申请人： Ulrich Deuschle , Ralph Loebbert , Beatrix Blume , Manfred Koegl , Claus Kremoser , Ingo Kober , Ulrike Bauer , Kristina Hermann , Michael Albers
发明人： Ulrich Deuschle , Ralph Loebbert , Beatrix Blume , Manfred Koegl , Claus Kremoser , Ingo Kober , Ulrike Bauer , Kristina Hermann , Michael Albers
IPC分类号： A61K31/517 , A61P3/06 , C07D239/95 , C07D401/12 , C07D403/04 , C07D405/12 , C07D43/02
CPC分类号： C07D401/12 , C07D239/95 , C07D405/12
摘要： The present invention relates to compounds according to the general formulas (I) and/or (Ia), which bind to the LXR receptors and act as agonists and antagonists of the LXR receptors. The invention further relates to the treatment of diseases and/or conditions through binding of said nuclear receptor by said compounds and the production of medicaments using said compounds.
摘要翻译： 本发明涉及结合LXR受体并作为LXR受体的激动剂和拮抗剂的根据通式（I）和/或（Ia）的化合物。 本发明还涉及通过所述化合物结合所述核受体和使用所述化合物生产药物来治疗疾病和/或病症。
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公开(公告)号：US20070010562A1
公开(公告)日：2007-01-11
申请号：US10486748
申请日：2002-08-13
申请人： Ulrike Bauer , Zach Cheruvallath , Ulrich Deuschle , Elena Dneprovskaia , Tim Gahman , Kristina Giegrich , Ronnie Hanecak , Normand Hebert , John Kiely , Ingo Kober , Manfred Kogl , Harald Kranz , Claus Kremoser , Matthew Lee , Kerstin Otte , Carlton Sage , Manish Sud
发明人： Ulrike Bauer , Zach Cheruvallath , Ulrich Deuschle , Elena Dneprovskaia , Tim Gahman , Kristina Giegrich , Ronnie Hanecak , Normand Hebert , John Kiely , Ingo Kober , Manfred Kogl , Harald Kranz , Claus Kremoser , Matthew Lee , Kerstin Otte , Carlton Sage , Manish Sud
IPC分类号： A61K31/4436 , A61K31/44 , C07D409/04 , C07D213/72
CPC分类号： C07D213/74 , C07B2200/11 , C07D261/08 , C07D277/42
摘要： The present invention relates to compounds according to the general formula (1) which bind to the NR1H4 receptor and act as agonists, antagonists or mixed agonists/antagonists of the NR1H4 receptor. The invention further relates to the treatment of diseases and/or conditions through binding of said nuclear receptor by said compounds and the production of medicaments using said compounds.
摘要翻译： 本发明涉及结合NR1H4受体并且作为NR1H4受体的激动剂，拮抗剂或混合激动剂/拮抗剂的根据通式（1）的化合物。 本发明还涉及通过所述化合物结合所述核受体和使用所述化合物生产药物来治疗疾病和/或病症。
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公开(公告)号：US07098336B2
公开(公告)日：2006-08-29
申请号：US10217141
申请日：2002-08-13
申请人： Ulrike Bauer , Zach Cheruvallath , Ulrich Deuschle , Elena Dneprovskaia , Tim Gahman , Kristina Giegrich , Ronnie Hanecak , Normand Hébert , John Kiely , Ingo Kober , Manfred Kögl , Harald Kranz , Claus Kremoser , Matthew Lee , Kerstin Otte , Carlton Sage , Manish Sud
发明人： Ulrike Bauer , Zach Cheruvallath , Ulrich Deuschle , Elena Dneprovskaia , Tim Gahman , Kristina Giegrich , Ronnie Hanecak , Normand Hébert , John Kiely , Ingo Kober , Manfred Kögl , Harald Kranz , Claus Kremoser , Matthew Lee , Kerstin Otte , Carlton Sage , Manish Sud
IPC分类号： C07D239/42 , A61K31/505 , A61K31/506 , A61P35/00
CPC分类号： C07D261/08 , C07B2200/11 , C07D213/74 , C07D239/42 , C07D409/04
摘要： The invention provides compounds according to the general formula (1) which bind to the NR1H4 receptor and act as agonists, antagonists or mixed agonists/antagonists of the NR1H4 receptor. The invention further provides methods of treating diseases and/or conditions through binding of the nuclear receptor by the compounds and the production of medicaments using the compounds.
摘要翻译： 本发明提供了结合NR 1 H 4受体并且作为NR 1 H 4受体的激动剂，拮抗剂或混合激动剂/拮抗剂的根据通式（1）的化合物。 本发明还提供了通过化合物与核受体结合并使用该化合物生产药物来治疗疾病和/或病症的方法。
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公开(公告)号：US07034046B2
公开(公告)日：2006-04-25
申请号：US10185721
申请日：2002-07-01
申请人： Ulrike Bauer , Zach Cheruvallath , Ulrich Deuschle , Elena Dneprovskaia , Tim Gahman , Kristina Giegrich , Ronnie Hanecak , Normand Hébert , John Kiely , Ingo Kober , Manfred Kögl , Harald Kranz , Claus Kremoser , Matthew Lee , Kerstin Otte , Carlton Sage , Manish Sud
发明人： Ulrike Bauer , Zach Cheruvallath , Ulrich Deuschle , Elena Dneprovskaia , Tim Gahman , Kristina Giegrich , Ronnie Hanecak , Normand Hébert , John Kiely , Ingo Kober , Manfred Kögl , Harald Kranz , Claus Kremoser , Matthew Lee , Kerstin Otte , Carlton Sage , Manish Sud
IPC分类号： A61K31/42 , C07D261/08
CPC分类号： C07D261/08 , C07B2200/11 , C07D213/74 , C07D239/42 , C07D409/04
摘要： The present invention relates to compounds according to the general formula (I) which bind to the nuclear receptor, NR1H4, and act as agonists and antagonists of the NR1H4 receptor. The invention further relates to the treatment of diseases and/or conditions through binding of the nuclear receptor by the compounds.
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公开(公告)号：US06974830B2
公开(公告)日：2005-12-13
申请号：US10185731
申请日：2002-07-01
申请人： Ulrike Bauer , Zach Cheruvallath , Ulrich Deuschle , Elena Dneprovskaia , Tim Gahman , Kristina Giegrich , Ronnie Hanecak , Normand Hébert , John Kiely , Ingo Kober , Manfred Kögl , Harald Kranz , Claus Kremoser , Matthew Lee , Kerstin Otte , Carlton Sage , Manish Sud
发明人： Ulrike Bauer , Zach Cheruvallath , Ulrich Deuschle , Elena Dneprovskaia , Tim Gahman , Kristina Giegrich , Ronnie Hanecak , Normand Hébert , John Kiely , Ingo Kober , Manfred Kögl , Harald Kranz , Claus Kremoser , Matthew Lee , Kerstin Otte , Carlton Sage , Manish Sud
IPC分类号： A61K31/42 , A61K31/506 , A61P3/04 , A61P9/00 , A61P35/00 , C07D213/74 , C07D239/42 , C07D261/08 , C07D277/38 , A61K31/426 , C07D277/20
CPC分类号： C07D261/08 , C07B2200/11 , C07D213/74 , C07D239/42 , C07D409/04
摘要： The present invention relates to compounds according to the general formula (I) which bind to the NR1H4 receptor and act as agonists of the NR1H4 receptor. The invention further relates to the treatment of diseases and/or conditions through binding of the nuclear receptor by the compounds and the production of medicaments using the compounds.
摘要翻译： 本发明涉及结合NR1H4受体并作为NR1H4受体激动剂的通式（I）的化合物。 本发明还涉及通过化合物与核受体的结合和使用该化合物的药物的生产来治疗疾病和/或病症。
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公开(公告)号：US20060148876A1
公开(公告)日：2006-07-06
申请号：US10526940
申请日：2003-07-02
申请人： Ulrich Deuschle , Stefanie Heck , Ingo Kober , Ulrike Bauer , Imola Balogh
发明人： Ulrich Deuschle , Stefanie Heck , Ingo Kober , Ulrike Bauer , Imola Balogh
IPC分类号： A61K31/416 , A61K31/415 , C07D405/02 , C07D231/12
CPC分类号： C07D231/12 , C07D405/04 , C07D409/04
摘要： The present invention relates to compounds according to the general formula (I) which bind to the NR3B1 receptor and act as antagonists or agonists of the NR3B1 receptor. The invention further relates to the treatment of diseases and/or conditions through binding of said nuclear receptor by said compounds and the production of medicaments using said compounds.
摘要翻译： 本发明涉及结合NR3B1受体并作为NR3B1受体的拮抗剂或激动剂的通式（I）的化合物。 本发明还涉及通过所述化合物结合所述核受体和使用所述化合物生产药物来治疗疾病和/或病症。
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