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1.发明申请Substituted 2, 6-diamino-3, 5-dicyano-4-arylpyridines and their use as adenosine-receptor-selective ligands 失效取代的2,6-二氨基-3,5-二氰基-4-芳基吡啶及其作为腺苷受体选择配体的用途公开(公告)号：US20070213372A1
公开(公告)日：2007-09-13
申请号：US11607262
申请日：2006-12-01
申请人： Ulrich Rosentreter , Thomas Kramer , Andrea Vaupel , Walter Hubsch , Nicole Diedrichs , Thomas Krahn , Klaus Dembowsky , Johannes-Peter Stasch
发明人： Ulrich Rosentreter , Thomas Kramer , Andrea Vaupel , Walter Hubsch , Nicole Diedrichs , Thomas Krahn , Klaus Dembowsky , Johannes-Peter Stasch
IPC分类号： A61K31/44 , C07D213/02
CPC分类号： C07D401/12 , C07D213/85 , C07D405/12 , C07D405/14 , C07D409/12 , C07D417/14
摘要： The present invention relates to substituted 2,6-diamino-3,5-dicyano-4-arylpyridines of the formula (I) wherein the definitions of substituent groups R1-R7 are as provided in the specification and claims, to a pharmaceutical composition containing such a compound, to a process for preparation of such materials, and to their use as medicaments for the treatment of cardiovascular disorders and diabetes.
摘要翻译： 本发明涉及式（I）的取代的2,6-二氨基-3,5-二氰基-4-芳基吡啶，其中取代基R 1〜R 7的定义< SUP>如说明书和权利要求书中所述，涉及含有这种化合物的药物组合物，其制备方法和用作治疗心血管疾病和糖尿病的药物。
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2.发明授权Substituted 2, 6-diamino-3, 5-dicyano-4-arylpyridines and their use as adenosine-receptor-selective ligands 失效取代的2,6-二氨基-3,5-二氰基-4-芳基吡啶及其作为腺苷受体选择配体的用途公开(公告)号：US08242281B2
公开(公告)日：2012-08-14
申请号：US11607262
申请日：2006-12-01
申请人： Ulrich Rosentreter , Thomas Kramer , Andrea Vaupel , Walter Hubsch , Nicole Diedrichs , Thomas Krahn , Klaus Dembowsky , Johannes-Peter Stasch
发明人： Ulrich Rosentreter , Thomas Kramer , Andrea Vaupel , Walter Hubsch , Nicole Diedrichs , Thomas Krahn , Klaus Dembowsky , Johannes-Peter Stasch
IPC分类号： C07D213/72 , C07D213/00 , A01N43/40
CPC分类号： C07D401/12 , C07D213/85 , C07D405/12 , C07D405/14 , C07D409/12 , C07D417/14
摘要： The present invention relates to substituted 2,6-diamino-3,5-dicyano-4-arylpyridines of the formula (I) wherein the definitions of substituent groups R1-R7 are as provided in the specification and claims, to a pharmaceutical composition containing such a compound, to a process for preparation of such materials, and to their use as medicaments for the treatment of cardiovascular disorders and diabetes.
摘要翻译： 本发明涉及式（I）的取代的2,6-二氨基-3,5-二氰基-4-芳基吡啶，其中取代基R1-R7的定义如说明书和权利要求中所述，含有 这样的化合物，制备这种材料的方法，以及它们作为用于治疗心血管疾病和糖尿病的药物的用途。
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3.发明申请Substituted 2-oxy-3,5-dicyano-4-aryl-6-aminopyridines and use thereof 失效取代的2-氧基-3,5-二氰基-4-芳基-6-氨基吡啶及其用途公开(公告)号：US20050261502A1
公开(公告)日：2005-11-24
申请号：US10469556
申请日：2002-02-20
申请人： Ulrich Rosentreter , Thomas Kramer , Andrea Vaupel , Walter Hubsch , Nicole Diedrichs , Thomas Krahn , Klaus Dembowsky , Johannes-Peter Stasch
发明人： Ulrich Rosentreter , Thomas Kramer , Andrea Vaupel , Walter Hubsch , Nicole Diedrichs , Thomas Krahn , Klaus Dembowsky , Johannes-Peter Stasch
IPC分类号： A61K31/44 , A61K31/443 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61P1/16 , A61P3/10 , A61P9/00 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/00 , A61P13/10 , A61P15/10 , A61P17/00 , A61P25/00 , A61P25/04 , A61P25/16 , A61P25/28 , A61P29/00 , A61P35/00 , C07D213/85 , C07D405/04 , C07D409/14 , C07D417/14 , C07D213/84
CPC分类号： C07D405/04 , C07D213/85 , C07D409/14 , C07D417/14
摘要： The use of compounds of formula (I) as medicaments, novel compounds of formula (I) and a method for production thereof are disclosed. Compounds of formula (I) are effective as adenosine receptor ligands.
摘要翻译： 公开了使用式（I）化合物作为药物，新的式（I）化合物及其制备方法。 式（I）化合物作为腺苷受体配体是有效的。
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公开(公告)号：US20060154969A1
公开(公告)日：2006-07-13
申请号：US10471079
申请日：2002-02-28
申请人： Ulrich Rosentreter , Thomas Kramer , Andrea Vaupel , Walter Hubsch , Nicole Diedrichs , Thomas Krahn , Klaus Dembowsky , Johannes-Peter Stasch
发明人： Ulrich Rosentreter , Thomas Kramer , Andrea Vaupel , Walter Hubsch , Nicole Diedrichs , Thomas Krahn , Klaus Dembowsky , Johannes-Peter Stasch
IPC分类号： A61K31/44 , C07D213/84
CPC分类号： C07D401/12 , C07D213/85 , C07D401/14 , C07D405/04 , C07D405/12 , C07D405/14
摘要： The invention relates to the compounds of formula (I), to a method for producing the same and to the use thereof as medicaments.
摘要翻译： 本发明涉及式（I）化合物，其制备方法及其作为药物的用途。
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公开(公告)号：US20060264432A1
公开(公告)日：2006-11-23
申请号：US11359927
申请日：2006-02-21
申请人： Ulrich Rosentreter , Rolf Henning , Marcus Bauser , Thomas Kramer , Andrea Vaupel , Walter Hubsch , Klaus Dembowsky , Olga Salcher-Schraufstatter , Johannes-Peter Stasch , Thomas Krahn , Elisabeth Perzborn
发明人： Ulrich Rosentreter , Rolf Henning , Marcus Bauser , Thomas Kramer , Andrea Vaupel , Walter Hubsch , Klaus Dembowsky , Olga Salcher-Schraufstatter , Johannes-Peter Stasch , Thomas Krahn , Elisabeth Perzborn
IPC分类号： A61K31/5377 , A61K31/496 , A61K31/4545 , A61K31/4439 , C07D413/02 , C07D403/02 , C07D401/02
CPC分类号： C07D401/12 , C07D213/85 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： The invention relates to compounds of general formula (I), a method for the production thereof and the use thereof as pharmacologically effective substances for a broad medical indication spectrum. Furthermore, selective adenosine receptor ligands, preferably selective adenosine A1-, adenosine A2a- and/or adenosine A2b-receptor ligands are provided for the prophylaxis and/or the treatment of diseases, especially cardiovascular diseases, diseases of the urogenital region, diseases of the respiratory tract, inflammatory and neuroinflammatory diseases, diabetes, especially pancreatic diabetes, neurodegenerative diseases, pain states, cancer as well as liver fibrosis and liver cirrhosis.
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6.发明申请Substituted 2, 6-Diamino-3, 5-Dicyano-4-Aryl-Pyridines And Their Use As Adenosine-Receptor-Selective Ligands 审中-公开取代的2,6-二氨基-3,5-二氰基-4-芳基吡啶及其作为腺苷受体选择性配体公开(公告)号：US20130040992A1
公开(公告)日：2013-02-14
申请号：US13584722
申请日：2012-08-13
申请人： Ulrich Rosentreter , Thomas Krämer , Andrea Vaupel , Walter Hübsch , Nicole Diedrichs , Thomas Krahn , Klaus Dembowsky , Johannes-Peter Stasch
发明人： Ulrich Rosentreter , Thomas Krämer , Andrea Vaupel , Walter Hübsch , Nicole Diedrichs , Thomas Krahn , Klaus Dembowsky , Johannes-Peter Stasch
IPC分类号： A61K31/444 , A61K31/4418 , C07D401/12 , A61K31/4439 , C07D409/12 , A61K31/4436 , A61K31/443 , C07D405/14 , C07D417/14 , A61P9/00 , A61P9/12 , A61P9/06 , A61P9/10 , A61P25/00 , C07D213/85
CPC分类号： C07D401/12 , C07D213/85 , C07D405/12 , C07D405/14 , C07D409/12 , C07D417/14
摘要： The present invention relates to substituted 2,6-diamino-3,5-dicyano-4-arylpyridines of the formula (I) wherein the definitions of substituent groups R1-R7 are as provided in the specification and claims, to a pharmaceutical composition containing such a compound, to a process for preparation of such materials, and to their use as medicaments for the treatment of cardiovascular disorders and diabetes.
摘要翻译： 本发明涉及式（I）的取代的2,6-二氨基-3,5-二氰基-4-芳基吡啶，其中取代基R1-R7的定义如说明书和权利要求中所述，含有 这样的化合物，制备这种材料的方法，以及它们作为用于治疗心血管疾病和糖尿病的药物的用途。
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7.发明授权Substituted 2-oxy-3,5-dicyano-4aryl-6-aminopyridines and use thereof 失效取代的2-氧基-3,5-二氰基-4-芳基-6-氨基吡啶及其用途公开(公告)号：US07855219B2
公开(公告)日：2010-12-21
申请号：US10469556
申请日：2002-02-20
申请人： Ulrich Rosentreter , Thomas Krämer , Andrea Vaupel , Walter Hübsch , Nicole Diedrichs , Thomas Krahn , Klaus Dembowsky , Johannes-Peter Stasch
发明人： Ulrich Rosentreter , Thomas Krämer , Andrea Vaupel , Walter Hübsch , Nicole Diedrichs , Thomas Krahn , Klaus Dembowsky , Johannes-Peter Stasch
IPC分类号： A61K31/44 , C07D405/00 , C07D401/00 , C07D417/00 , C07D409/00
CPC分类号： C07D405/04 , C07D213/85 , C07D409/14 , C07D417/14
摘要： This invention relates to compounds of formula (I) in which the variable groups are as defined in the text and claims. A pharmaceutical composition and methods of using these materials in treatment of various conditions are also disclosed and claimed.
摘要翻译： 本发明涉及式（I）化合物，其中可变基团如本文和权利要求中所定义。 还公开并要求保护的药物组合物和使用这些材料处理各种条件的方法。
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8.发明授权Substituted 2-carba-3,5-dicyano-4-aryl-6-aminopyridines and the use of the same as selective ligands of the adenosine receptor 失效取代的2-咔唑-3,5-二氰基-4-芳基-6-氨基吡啶并使用其作为腺苷受体的选择性配体公开(公告)号：US07129255B2
公开(公告)日：2006-10-31
申请号：US10473371
申请日：2002-03-25
申请人： Ulrich Rosentreter , Thomas Krämer , Andrea Vaupel , Walter Hübsch , Nicole Diedrichs , Thomas Krahn , Klaus Dembowsky , Johannes-Peter Stasch , Mitsuyuki Shimada
发明人： Ulrich Rosentreter , Thomas Krämer , Andrea Vaupel , Walter Hübsch , Nicole Diedrichs , Thomas Krahn , Klaus Dembowsky , Johannes-Peter Stasch , Mitsuyuki Shimada
IPC分类号： A61K31/44 , C07D213/85
CPC分类号： C07D405/04 , C07D213/85
摘要： This application relates to compounds of the formula wherein the groups R1–R6 are as defined in the specification and claims, and to a pharmaceutical composition containing the same, and to a method of using the same in treatment of cardiovascular disorders.
摘要翻译： 本申请涉及下式的化合物，其中基团R 1〜6 6如说明书和权利要求中所定义，并且含有该化合物的药物组合物，以及 使用该方法治疗心血管疾病的方法。
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9.发明授权Substituted 2-thio-3,5-dicyano-4-phenyl-6-aminopyridines with adenosine receptor-binding activity and their use as cardiovascular preparations 失效具有腺苷受体结合活性的取代的2-硫代-3,5-二氰基-4-苯基-6-氨基吡啶并将其用作心血管制剂公开(公告)号：US07078417B2
公开(公告)日：2006-07-18
申请号：US10473372
申请日：2002-03-19
申请人： Ulrich Rosentreter , Thomas Krämer , Andrea Vaupel , Walter Hübsch , Nicole Diedrichs , Thomas Krahn , Klaus Dembowsky , Johannes-Peter Stasch , Mitsuyuki Shimada
发明人： Ulrich Rosentreter , Thomas Krämer , Andrea Vaupel , Walter Hübsch , Nicole Diedrichs , Thomas Krahn , Klaus Dembowsky , Johannes-Peter Stasch , Mitsuyuki Shimada
IPC分类号： A61K31/443 , A61K33/4433 , C07D405/04
CPC分类号： C07D405/04 , C07D213/84 , C07D213/85 , C07D405/14 , C07D417/14
摘要： This application relates to pyridine derivatives having the general structure in which the several variables are as defined in the specification and claims, and to a process for preparing these compounds, a pharmacutical composition containing such compounds, and a method for using these materials for treatment of stable and unstable angina pectoris and atrial fibrillation.
摘要翻译： 本申请涉及具有一般结构的吡啶衍生物，其中几个变量如说明书和权利要求书中所定义，以及制备这些化合物的方法，含有这些化合物的药物组合物，以及使用这些材料用于治疗 稳定和不稳定的心绞痛和心房颤动。
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10.发明授权Substituted 2-thio-3,5-dicyano-4-aryl-6-aminopyridines and their use 失效取代的2-硫代-3,5-二氰基-4-芳基-6-氨基吡啶及其用途公开(公告)号：US07504421B2
公开(公告)日：2009-03-17
申请号：US11359927
申请日：2006-02-21
申请人： Ulrich Rosentreter , Rolf Henning , Marcus Bauser , Thomas Krämer , Andrea Vaupel , Walter Hübsch , Klaus Dembowsky , Olga Salcher-Schraufstatter , Johannes-Peter Stasch , Thomas Krahn , Elisabeth Perzborn
发明人： Ulrich Rosentreter , Rolf Henning , Marcus Bauser , Thomas Krämer , Andrea Vaupel , Walter Hübsch , Klaus Dembowsky , Olga Salcher-Schraufstatter , Johannes-Peter Stasch , Thomas Krahn , Elisabeth Perzborn
IPC分类号： C07D213/85 , A61K31/44
CPC分类号： C07D401/12 , C07D213/85 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： The invention relates to compounds of general formula (I), a method for the production thereof and the use thereof as pharmacologically effective substances for a broad medical indication spectrum. Furthermore, selective adenosine receptor ligands, preferably selective adenosine A1-, adenosine A2a- and/or adenosine A2b-receptor ligands are provided for the prophylaxis and/or the treatment of diseases, especially cardiovascular diseases, diseases of the urogenital region, diseases of the respiratory tract, inflammatory and neuroinflammatory diseases, diabetes, especially pancreatic diabetes, neurodegenerative diseases, pain states, cancer as well as liver fibrosis and liver cirrhosis.
摘要翻译： 本发明涉及通式（I）的化合物，其制备方法及其作为广泛医学指征谱的药理学有效物质的用途。 此外，提供选择性腺苷受体配体，优选选择性腺苷A1-，腺苷A2a-和/或腺苷A2b-受体配体用于预防和/或治疗泌尿生殖区疾病，特别是心血管疾病，泌尿生殖系疾病 呼吸道，炎性和神经炎症性疾病，糖尿病，特别是胰腺糖尿病，神经变性疾病，疼痛状态，癌症以及肝纤维化和肝硬化。
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