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公开(公告)号：US20120021978A1
公开(公告)日：2012-01-26
申请号：US13123835
申请日：2009-10-09
CPC分类号： A61K38/28 , A61K38/26 , A61K2300/00
摘要： The invention relates to a drug comprising at least one insulin and at least one GLP-1 receptor agonist.
摘要翻译： 本发明涉及包含至少一种胰岛素和至少一种GLP-1受体激动剂的药物。
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公开(公告)号：US09526764B2
公开(公告)日：2016-12-27
申请号：US13123835
申请日：2009-10-09
申请人： Ulrich Werner , Barbel Rotthauser
发明人： Ulrich Werner , Barbel Rotthauser
CPC分类号： A61K38/28 , A61K38/26 , A61K2300/00
摘要： The invention relates to a drug comprising at least one insulin and at least one GLP-1 receptor agonist.
摘要翻译： 本发明涉及包含至少一种胰岛素和至少一种GLP-1受体激动剂的药物。
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公开(公告)号：US09644017B2
公开(公告)日：2017-05-09
申请号：US12820722
申请日：2010-06-22
申请人： Paul Habermann , Gerhard Seipke , Roland Kurrle , Gunter Muller , Mark Sommerfeld , Norbert Tennagels , Georg Tschank , Ulrich Werner
发明人： Paul Habermann , Gerhard Seipke , Roland Kurrle , Gunter Muller , Mark Sommerfeld , Norbert Tennagels , Georg Tschank , Ulrich Werner
摘要： The invention relates to novel insulin analogs having a basal time-action profile, which are characterized by the following features: a) the B chain end consists of an amidated basic amino acid residue such as lysine or arginine amide; b) the N-terminal amino acid residue of the insulin A chain is a lysine or arginine radical; c) the amino acid position A8 is occupied by a histidine radical; d) the amino acid position A21 is occupied by a glycine radical; and e) one or more substitutions and/or additions of negatively charged amino acid residues are carried out in the positions A5, A15, A18, B-1, B0, B1, B2, B3 and B4.
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4.发明授权Bicyclic cyanoheterocycles, process for their preparation and their use as medicaments 有权双环氰基杂环，其制备方法及其用作药物公开(公告)号：US07008957B2
公开(公告)日：2006-03-07
申请号：US10898751
申请日：2004-07-26
申请人： Holger Wagner , Karl Schoenafinger , Gerhard Jaehne , Holger Gaul , Christian Buning , Georg Tschank , Ulrich Werner
发明人： Holger Wagner , Karl Schoenafinger , Gerhard Jaehne , Holger Gaul , Christian Buning , Georg Tschank , Ulrich Werner
IPC分类号： A61K31/428 , A61K31/454 , A61K31/5377 , C07D417/02 , C07D277/60
CPC分类号： C07D487/04
摘要： The invention relates to compounds of the formula I in which the radicals have the stated meanings, their stereoisomeric forms and their physiologically tolerated salts and process for their preparation. The compounds are suitable for the treatment of metabohlic disorders such as type 2 diabetes.
摘要翻译： 本发明涉及式Ⅰ化合物，其中基团具有所述含义，它们的立体异构形式及其生理上可耐受的盐及其制备方法。 该化合物适用于治疗代谢性疾病如2型糖尿病。
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5.发明申请Novel cyanopyrrolidides, process for their preparation and their use as medicaments 有权新型氰基吡咯烷酮，其制备方法及其作为药物的用途公开(公告)号：US20050059724A1
公开(公告)日：2005-03-17
申请号：US10898752
申请日：2004-07-26
申请人： Karl Schoenafinger , Holger Wagner , Gerhard Jaehne , Holger Gaul , Christian Buning , Georg Tschank , Ulrich Werner
发明人： Karl Schoenafinger , Holger Wagner , Gerhard Jaehne , Holger Gaul , Christian Buning , Georg Tschank , Ulrich Werner
IPC分类号： C07D487/04 , A61K31/407
CPC分类号： C07D487/04
摘要： The invention relates to compounds of the formula I in which the radicals have the meanings stated in the text, their stereoisomeric forms, and their physiologically tolerated salts, physiologically functional derivatives and process for their preparation. The compounds are suitable for the treatment of disorders of metabolism, such as type 2 diabetes.
摘要翻译： 本发明涉及式I化合物，其中基团具有文中所述的含义，它们的立体异构形式及其生理学上可耐受的盐，生理功能衍生物及其制备方法。 该化合物适用于治疗代谢紊乱，如2型糖尿病。
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6.发明授权Substituted 2-aminoalkylthiobenzimidazole compounds, pharmaceutical compositions thereof and methods for their use 有权取代的2-氨基烷硫基苯并咪唑化合物，其药物组合物及其使用方法公开(公告)号：US07795445B2
公开(公告)日：2010-09-14
申请号：US11855221
申请日：2007-09-14
申请人： Elisabeth Defossa , Karl Schoenafinger , Gerhard Jaehne , Christian Buning , Georg Tschank , Ulrich Werner
发明人： Elisabeth Defossa , Karl Schoenafinger , Gerhard Jaehne , Christian Buning , Georg Tschank , Ulrich Werner
IPC分类号： A61K31/4184 , C07D235/28
CPC分类号： C07D235/28
摘要： The present invention comprises the substituted 2-aminoalkylthiobenzimidazoles of formula I wherein R1-R5 and R11-R16 are hereinafter defined. These compounds, their derivatives and the pharmaceutically acceptable salts thereof are useful in the reduction of elevated blood sugar levels and are therefore useful in the treatment of hyperglycemia, diabetes, atherosclerosis and other blood sugar disorders. These compounds are particularly suitable in the treatment of type-2 diabetes.
摘要翻译： 本发明包括式I的取代的2-氨基烷硫基苯并咪唑，其中R1-R5和R11-R16在下文中定义。 这些化合物，其衍生物及其药学上可接受的盐可用于降低升高的血糖水平，因此可用于治疗高血糖症，糖尿病，动脉粥样硬化和其他血糖障碍。 这些化合物特别适用于治疗2型糖尿病。
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7.发明申请Novel bicyclic cyanoheterocycles, process for their preparation and their use as medicaments 有权新型双环氰基杂环，其制备方法及其用作药物公开(公告)号：US20050059716A1
公开(公告)日：2005-03-17
申请号：US10898751
申请日：2004-07-26
申请人： Holger Wagner , Karl Schoenafinger , Gerhard Jaehne , Holger Gaul , Christian Buning , Georg Tschank , Ulrich Werner
发明人： Holger Wagner , Karl Schoenafinger , Gerhard Jaehne , Holger Gaul , Christian Buning , Georg Tschank , Ulrich Werner
IPC分类号： C07D487/04 , C07D513/02 , A61K31/4188 , A61K31/424 , A61K31/428
CPC分类号： C07D487/04
摘要： The invention relates to compounds of the formula I in which the radicals have the stated meanings, their stereoisomeric forms and their physiologically tolerated salts and process for their preparation. The compounds are suitable for the treatment of metabohlic disorders such as type 2 diabetes.
摘要翻译： 本发明涉及式Ⅰ化合物，其中基团具有所述含义，它们的立体异构形式及其生理上可耐受的盐及其制备方法。 该化合物适用于治疗代谢性疾病如2型糖尿病。
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8.发明授权Amide-substituted 8-N-benzimidazoles, method for the production thereof, and use of the same as medicaments 有权酰胺取代的8-N-苯并咪唑，其制备方法及其用途公开(公告)号：US08163774B2
公开(公告)日：2012-04-24
申请号：US11854578
申请日：2007-09-13
申请人： Elisabeth DeFossa , Karl Schoenafinger , Gerhard Jaehne , Christian Buning , Georg Tschank , Ulrich Werner
发明人： Elisabeth DeFossa , Karl Schoenafinger , Gerhard Jaehne , Christian Buning , Georg Tschank , Ulrich Werner
IPC分类号： A61K31/445 , C07D401/00
CPC分类号： C07D401/04 , C07D401/14
摘要： The present invention comprises the use of amino-substituted 8-N-benzimidazoles compounds of formula I wherein R3, R4-R5, R11 and R20-R21 are hereinafter defined which display a therapeutically utilizable blood sugar-lowering action. These compounds are intended to be particularly suitable in the treatment of diabetes.
摘要翻译： 本发明包括使用式I的氨基取代的8-N-苯并咪唑化合物，其中R3，R4-R5，R11和R20-R21在下文中定义，其显示出治疗上可用的降血糖作用。 这些化合物特别适用于治疗糖尿病。
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9.发明授权Amino-substituted 8-N-benzimidazoles and methods for their use in blood sugar disorders 有权氨基取代的8-N-苯并咪唑及其用于血糖障碍的方法公开(公告)号：US08003668B2
公开(公告)日：2011-08-23
申请号：US11855231
申请日：2007-09-14
申请人： Elisabeth Defossa , Karl Schoenafinger , Gerhard Jaehne , Christian Buning , Georg Tschank , Ulrich Werner
发明人： Elisabeth Defossa , Karl Schoenafinger , Gerhard Jaehne , Christian Buning , Georg Tschank , Ulrich Werner
IPC分类号： A61K31/445 , C07D401/00
CPC分类号： C07D401/04 , A61K31/454
摘要： The present invention comprises the use of amino-substituted 8-N-benzimidazoles compounds of formula I wherein R3, R4-R5, R11 and R20-R21 are hereinafter defined which display a therapeutically utilizable blood sugar-lowering action. These compounds are intended to be particularly suitable in the treatment of diabetes.
摘要翻译： 本发明包括使用式I的氨基取代的8-N-苯并咪唑化合物，其中R3，R4-R5，R11和R20-R21在下文中定义，其显示出治疗上可用的降血糖作用。 这些化合物特别适用于治疗糖尿病。
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10.发明授权Substituted 8-aminoalkoxy-xanthine compounds and compositions useful in the treatment of hyperlipidemia and diabetes 有权取代的8-氨基烷氧基 - 黄嘌呤化合物和可用于治疗高脂血症和糖尿病的组合物公开(公告)号：US07879864B2
公开(公告)日：2011-02-01
申请号：US11674261
申请日：2007-02-13
申请人： Karl Schoenafinger , Gerhard Jaehne , Elisabeth Defossa , Christian Buning , Georg Tschank , Ulrich Werner
发明人： Karl Schoenafinger , Gerhard Jaehne , Elisabeth Defossa , Christian Buning , Georg Tschank , Ulrich Werner
IPC分类号： C07D473/02 , A61K31/522 , A61P3/10 , A61P3/06
CPC分类号： C07D473/04
摘要： Compounds for the treatment of elevated blood glucose levels and the physiological and metabolic disorders arising therefrom are disclosed which are inhibitors of the enzyme dipeptidyl peptidase IV (DDP-IV) and comprise novel substituted bicyclic 8-pyrrolidinoxanthines of formula I and their derivatives: wherein the various R-groups are defined herein. These compounds may be combined with other secondary active compounds which also are effective in the treatment of said disorders and the disease states or physiological manifestations arising therefrom.
摘要翻译： 公开了用于治疗升高的血糖水平的化合物和由此产生的生理和代谢紊乱，其是酶二肽基肽酶IV（DDP-IV）的抑制剂，并且包含式I的新型取代的双环8-吡咯烷基亚基黄嘌呤及其衍生物：其中 本文定义了各种R基团。 这些化合物可以与其它二级活性化合物组合，其也可有效治疗所述疾病以及由此产生的疾病状态或生理表现。
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