摘要:
Method, compositions, and compounds for modulating brain excitability to alleviate stress, anxiety, and seizure activity using certain steroid derivatives that act at a newly identified site on the gamma-ammobutyric acid/benzodiazepine receptor-chloride ionophore (GBR) complex.
摘要:
Steroid compounds having increased resistance against metabolism and increased water solubility are disclosed, together with methods for their production. These substances are suitable for the manufacture of pharmaceuticals for the treatment of steroid related or steroid induced CNS disorders and for use in methods of prevention, alleviation or treatment of such disorders.
摘要:
Steroid compounds having increased resistance against metabolism and increased water solubility are disclosed, together with methods for their production. These substances are suitable for the manufacture of pharmaceuticals for the treatment of steroid related or steroid induced CNS disorders and for use in methods of prevention, alleviation or treatment of such disorders.
摘要:
Method, compositions, and compounds for modulating brain excitability to alleviate stress, anxiety, insomnia and seizure activity using certain steroid derivatives that act at a newly identified site on the gamma-aminobutyric acid receptor-chloride ionophore (GR) complex.
摘要:
Method, compositions, and compounds for modulating brain excitability to alleviate stress, anxiety, and seizure activity using certain steroid derivatives that act at a newly identified site on the gamma-ammobutyric acid/benzodiazepine receptor-chloride ionpore (GBR) complex.
摘要:
Steroid compounds having increased resistance against metabolism and increased water solubility are disclosed, together with methods for their production. These substances are suitable for the manufacture of pharmaceuticals for the treatment of steroid related or steroid induced CNS disorders and for use in methods of prevention, alleviation or treatment of such disorders.
摘要:
Steroid compounds having increased resistance against metabolism and increased water solubility are disclosed, together with methods for their production. These substances are suitable for the manufacture of pharmaceuticals for the treatment of steroid related or steroid induced CNS disorders and for use in methods of prevention, alleviation or treatment of such disorders.
摘要:
Steroid compounds having increased resistance against metabolism and increased water solubility are disclosed, together with methods for their production. These substances are suitable for the manufacture of pharmaceuticals for the treatment of steroid related or steroid induced CNS disorders and for use in methods of prevention, alleviation or treatment of such disorders.
摘要:
Process for the formation of carbon-containing free radicals R., which optionally include functional groups, wherein thermal and/or photochemical energy is supplied to a thiocarbonyl-containing ester corresponding to the general formula (I): ##STR1## in which: R denotes a saturated or unsaturated, linear or branched, aliphatic or aromatic, acyclic or alternatively mono- or poly-cyclic or mono- or poly-heterocyclic, carbon-containing radical which in addition can optionally include functional groups;R' and R" denote, independently of each other, an alkyl, alkenyl, aryl, aralkyl or alkaryl radical, or alternatively form together a 5- or 6-membered nitrogen-containing heterocycle which can also contain an additional heteroatom chosen from nitrogen and sulfur and which can optionally be substituted or fused to at least one other aliphatic or aromatic ring;R.sub.1 and R.sub.2 denote, independently of each other, a hydrogen atom or a lower alkyl radical, andn is an integer equal to 0, 1, 2 or 3.
摘要翻译:用于形成含碳自由基R的方法,其任选包括官能团,其中将热和/或光化学能提供给对应于通式(I)的含硫代羰基的酯:其中 其中:R表示饱和或不饱和的直链或支链,脂族或芳族,无环或可选的单环或多环或单 - 或多杂环含碳基团,其另外可任选地包括官能团; R'和R“彼此独立地表示烷基,烯基,芳基,芳烷基或烷芳基,或者另外形成5-或6-元含氮杂环,其也可以含有选自氮的另外的杂原子 和硫,并且其可任选地被取代或稠合至至少一个其它脂族或芳族环; R 1和R 2彼此独立地表示氢原子或低级烷基,n是等于0,1,2或3的整数。
摘要:
Steroid compounds having increased resistance against metabolism and increased water solubility are disclosed, together with methods for their production. These substances are suitable for the manufacture of pharmaceuticals for the treatment of steroid related or steroid induced CNS disorders and for use in methods of prevention, alleviation or treatment of such disorders.