公开(公告)号：US20140186969A1

公开(公告)日：2014-07-03

申请号：US14066797

申请日：2013-10-30

Applicant: Universite D'Aix-Marseille

Inventor： Oliver Ouari ,  Hakim Karoui ,  Francois Le Moigne ,  Paul Tordo ,  Robert S. Griffin ,  Yoh Matsuki ,  Thorstep Maly

IPC: G01N1/28

CPC classification number: G01N1/28 ,  C07D471/18 ,  C07D491/22 ,  G01R33/281 ,  G01R33/5601 ,  Y10T436/25

Abstract: The present invention relates to the field of organic chemistry and in particular to organic free radicals used as polarizing agents in the technique of Dynamic Nuclear Polarization (DNP), which involves transferring the polarization of electron spins to the nuclei of a compound whose Nuclear Magnetic Resonance (NMR) is being observed. It concerns Dinitroxide-type Biradical polarizing agents characterized by a rigid linkage between the aminoxyl groups of said nitroxide units. This particular structure enables, at low temperatures and high fields, optimal transfer of polarization and optimal enhancement of NMR/MAS signals of the polarized nuclei of the compound studied.

Abstract translation: 本发明涉及有机化学领域，特别涉及在动态核极化（DNP）技术中用作极化剂的有机自由基，其涉及将电子自旋的极化转移到核磁共振的化合物的核上 （NMR）。 它涉及以硝基氧单元的氨基之间的刚性连接为特征的二氧化氮型双基极化剂。 这种特殊结构使得在低温和高场下，所研究的化合物的极化核的NMR / MAS信号的极化转移和最佳增强是最佳的。

公开(公告)号：US09035054B2

公开(公告)日：2015-05-19

申请号：US14066797

申请日：2013-10-30

Applicant: Universite D'Aix-Marseille

Inventor： Oliver Ouari ,  Hakim Karoui ,  Francois Le Moigne ,  Paul Tordo ,  Robert G. Griffin ,  Yoh Matsuki ,  Thorsten Maly

IPC: C07D235/02 ,  C07D207/48 ,  C07D263/52 ,  C07D409/02 ,  C07D409/14 ,  G01N1/28 ,  C07D471/18 ,  C07D491/22 ,  G01R33/28 ,  G01R33/56

CPC classification number: G01N1/28 ,  C07D471/18 ,  C07D491/22 ,  G01R33/281 ,  G01R33/5601 ,  Y10T436/25

Abstract: The present invention relates to the field of organic chemistry and in particular to organic free radicals used as polarizing agents in the technique of Dynamic Nuclear Polarization (DNP), which involves transferring the polarization of electron spins to the nuclei of a compound whose Nuclear Magnetic Resonance (NMR) is being observed. It concerns Dinitroxide-type Biradical polarizing agents characterized by a rigid linkage between the aminoxyl groups of said nitroxide units. This particular structure enables, at low temperatures and high fields, optimal transfer of polarization and optimal enhancement of NMR/MAS signals of the polarized nuclei of the compound studied.

Abstract translation: 本发明涉及有机化学领域，特别涉及在动态核极化（DNP）技术中用作极化剂的有机自由基，其涉及将电子自旋的极化转移到核磁共振的化合物的核上 （NMR）。 它涉及以硝基氧单元的氨基之间的刚性连接为特征的二氧化氮型双基极化剂。 这种特殊结构使得在低温和高场下，所研究的化合物的极化核的NMR / MAS信号的极化转移和最佳增强是最佳的。