公开(公告)号：US20190060472A1

公开(公告)日：2019-02-28

申请号：US15924520

申请日：2018-03-19

申请人： University Court of the University of Dundee

发明人： Steven Albert Everett ,  Saraj Ulhaq

IPC分类号： A61K47/54 ,  C07D491/22 ,  A61K31/513 ,  C07D417/12 ,  C07D409/12 ,  C07D407/12 ,  C07D405/14 ,  C07D405/12 ,  C07D405/04 ,  C07D311/18 ,  C07D311/16 ,  C07D307/80 ,  A61K31/664 ,  A61K31/428 ,  A61K31/4184 ,  A61K31/352 ,  A61K31/343 ,  A61K31/52 ,  A61K31/665 ,  A61K31/37 ,  A61K31/381 ,  C07D487/04

摘要： The invention relates to novel compounds for use in the treatment or prophylaxis of cancers and other proliferative conditions that are for example characterized by cells that express cytochrome P450 1B1 (CYP1B1) and allelic variants thereof. The invention also provides pharmaceutical compositions comprising one or more such compounds for use in medical therapy, for example in the treatment of prophylaxis of cancers or other proliferative conditions, as well as methods for treating cancers or other conditions in human or non-human animal patients. The invention also provides methods for identifying novel compounds for use in the treatment of prophylaxis of cancers and other proliferative conditions that are for example characterized by cells that express CYP1 B1 and allelic variants thereof. The invention also provides a method for determining the efficacy of a compound of the invention in treating cancer.

公开(公告)号：US20170368188A1

公开(公告)日：2017-12-28

申请号：US15425758

申请日：2017-02-06

申请人： University Court of the University of Dundee

发明人： Steven Albert Everett ,  Saraj Ulhaq

IPC分类号： A61K47/54 ,  A61K31/343 ,  C07D417/12 ,  C07D409/12 ,  C07D407/12 ,  C07D405/14 ,  C07D405/12 ,  C07D405/04 ,  C07D311/18 ,  C07D311/16 ,  C07D307/80 ,  A61K31/665 ,  A61K31/664 ,  A61K31/52 ,  A61K31/513 ,  A61K31/428 ,  A61K31/4184 ,  A61K31/381 ,  A61K31/37 ,  A61K31/352 ,  C07D487/04 ,  C07D491/22

CPC分类号： A61K47/545 ,  A61K31/343 ,  A61K31/352 ,  A61K31/37 ,  A61K31/381 ,  A61K31/4184 ,  A61K31/428 ,  A61K31/513 ,  A61K31/52 ,  A61K31/664 ,  A61K31/665 ,  C07D307/80 ,  C07D311/16 ,  C07D311/18 ,  C07D405/04 ,  C07D405/12 ,  C07D405/14 ,  C07D407/12 ,  C07D409/12 ,  C07D417/12 ,  C07D487/04 ,  C07D491/22

摘要： The invention relates to novel compounds for use in the treatment or prophylaxis of cancers and other proliferative conditions that are for example characterized by cells that express cytochromne P450 1B1 (CYP1B1) and allelic variants thereof. The invention also provides pharmaceutical compositions comprising one or more such compounds for use in medical therapy, for example in the treatment of prophylaxis of cancers or other proliferative conditions, as well as methods for treating cancers or other conditions in human or non-human animal patients. The invention also provides methods for identifying novel compounds for use in the treatment of prophylaxis of cancers and other proliferative conditions that are for example characterized by cells that express CYP1 B1 and allelic variants thereof. The invention also provides a method for determining the efficacy of a compound of the invention in treating cancer.

公开(公告)号：US20220031852A1

公开(公告)日：2022-02-03

申请号：US17200065

申请日：2021-03-12

申请人： University Court of the University of Dundee

发明人： Steven Albert Everett ,  Saraj Ulhaq

IPC分类号： A61K47/54 ,  A61K31/343 ,  A61K31/352 ,  A61K31/4184 ,  A61K31/428 ,  A61K31/664 ,  C07D307/80 ,  C07D311/16 ,  C07D311/18 ,  C07D405/04 ,  C07D405/12 ,  C07D405/14 ,  C07D407/12 ,  C07D409/12 ,  C07D417/12 ,  C07D487/04 ,  C07D491/22 ,  A61K31/37 ,  A61K31/381 ,  A61K31/513 ,  A61K31/52 ,  A61K31/665

摘要： The invention relates to novel compounds for use in the treatment or prophylaxis of cancers and other proliferative conditions that are for example characterized by cells that express cytochrome P450 1B1 (CYP1B1) and allelic variants thereof. The invention also provides pharmaceutical compositions comprising one or more such compounds for use in medical therapy, for example in the treatment of prophylaxis of cancers or other proliferative conditions, as well as methods for treating cancers or other conditions in human or non-human animal patients. The invention also provides methods for identifying novel compounds for use in the treatment of prophylaxis of cancers and other proliferative conditions that are for example characterized by cells that express CYP1 B1 and allelic variants thereof. The invention also provides a method for determining the efficacy of a compound of the invention in treating cancer.

公开(公告)号：US20150011512A1

公开(公告)日：2015-01-08

申请号：US14485122

申请日：2014-09-12

申请人： University Court of the University of Dundee

发明人： Steven Albert Everett ,  Saraj Ulhaq

IPC分类号： A61K47/48 ,  A61K31/37 ,  A61K31/4184 ,  A61K31/343 ,  A61K31/428 ,  A61K31/52 ,  A61K31/513 ,  A61K31/665 ,  A61K31/381

CPC分类号： A61K47/545 ,  A61K31/343 ,  A61K31/352 ,  A61K31/37 ,  A61K31/381 ,  A61K31/4184 ,  A61K31/428 ,  A61K31/513 ,  A61K31/52 ,  A61K31/664 ,  A61K31/665 ,  C07D307/80 ,  C07D311/16 ,  C07D311/18 ,  C07D405/04 ,  C07D405/12 ,  C07D405/14 ,  C07D407/12 ,  C07D409/12 ,  C07D417/12 ,  C07D487/04 ,  C07D491/22

摘要： The invention relates to novel compounds for use in the treatment or prophylaxis of cancers and other proliferative conditions that are for example characterized by cells that express cytochrome P450 1B1 (CYP1B1) and allelic variants thereof. The invention also provides pharmaceutical compositions comprising one or more such compounds for use in medical therapy, for example in the treatment of prophylaxis of cancers or other proliferative conditions, as well as methods for treating cancers or other conditions in human or non-human animal patients. The invention also provides methods for identifying novel compounds for use in the treatment of prophylaxis of cancers and other proliferative conditions that are for example characterized by cells that express CYP1 B1 and allelic variants thereof. The invention also provides a method for determining the efficacy of a compound of the invention in treating cancer.

摘要翻译： 本发明涉及用于治疗或预防癌症和其它增殖性病症的新化合物，其特征在于表达细胞色素P450 1B1（CYP1B1）和其等位基因变体的细胞。 本发明还提供药物组合物，其包含用于医学治疗的一种或多种这样的化合物，例如用于治疗癌症或其它增殖性疾病的预防，以及用于治疗人或非人动物患者中的癌症或其它病症的方法 。 本发明还提供了用于鉴定用于治疗预防癌症和其它增殖性病症的新化合物的方法，其特征在于表达CYP1B1的细胞及其等位变体。 本发明还提供了确定本发明化合物治疗癌症的功效的方法。

公开(公告)号：US09919060B2

公开(公告)日：2018-03-20

申请号：US15425758

申请日：2017-02-06

申请人： University Court of the University of Dundee

发明人： Steven Albert Everett ,  Saraj Ulhaq

IPC分类号： A61K47/48 ,  A61K31/37 ,  A61K31/52 ,  A61K31/343 ,  A61K31/381 ,  A61K31/428 ,  A61K31/513 ,  A61K31/665 ,  A61K47/54 ,  C07D491/22 ,  C07D487/04 ,  C07D417/12 ,  C07D409/12 ,  C07D407/12 ,  C07D405/14 ,  C07D405/12 ,  C07D405/04 ,  C07D311/18 ,  C07D311/16 ,  C07D307/80 ,  A61K31/664 ,  A61K31/4184 ,  A61K31/352

CPC分类号： A61K47/545 ,  A61K31/343 ,  A61K31/352 ,  A61K31/37 ,  A61K31/381 ,  A61K31/4184 ,  A61K31/428 ,  A61K31/513 ,  A61K31/52 ,  A61K31/664 ,  A61K31/665 ,  C07D307/80 ,  C07D311/16 ,  C07D311/18 ,  C07D405/04 ,  C07D405/12 ,  C07D405/14 ,  C07D407/12 ,  C07D409/12 ,  C07D417/12 ,  C07D487/04 ,  C07D491/22

摘要： The invention relates to novel compounds for use in the treatment or prophylaxis of cancers and other proliferative conditions that are for example characterized by cells that express cytochrome P450 1B1 (CYP1B1) and allelic variants thereof. The invention also provides pharmaceutical compositions comprising one or more such compounds for use in medical therapy, for example in the treatment of prophylaxis of cancers or other proliferative conditions, as well as methods for treating cancers or other conditions in human or non-human animal patients. The invention also provides methods for identifying novel compounds for use in the treatment of prophylaxis of cancers and other proliferative conditions that are for example characterized by cells that express CYP1 B1 and allelic variants thereof. The invention also provides a method for determining the efficacy of a compound of the invention in treating cancer.