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公开(公告)号：US20220034805A1
公开(公告)日：2022-02-03
申请号：US17277684
申请日：2019-09-17
摘要： A method for use in imaging an object through a scattering medium comprises illuminating the object sequentially point-by-point through the scattering medium with incident electromagnetic radiation propagating along an illumination direction so that the incident electromagnetic radiation interacts with the object to cause the object to generate and emit electromagnetic radiation, wherein the incident electromagnetic radiation is formed by spectrally dispersing initial electromagnetic radiation in a direction transverse to the illumination direction so as to form spectrally dispersed electromagnetic radiation and by spatially focusing the spectrally dispersed electromagnetic radiation through the scattering medium to the object. The method comprises measuring, for each illuminated point of the object, a corresponding value representative of a quantity of at least a portion of the corresponding emitted electromagnetic radiation and using, for each illuminated point of the object, position information for the illuminated point and the corresponding measured value to determine an image of the object.
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公开(公告)号：US20220003980A1
公开(公告)日：2022-01-06
申请号：US17280112
申请日：2019-09-24
摘要： A method for use in light-sheet imaging of an object through a scattering medium comprises illuminating the object through the scattering medium with incident electromagnetic radiation propagating along an illumination axis so that the incident electromagnetic radiation interacts with the object to cause the object to generate and emit electromagnetic radiation. The incident electromagnetic radiation is formed by spectrally dispersing initial electromagnetic radiation in a direction transverse to the illumination axis so as to form spectrally dispersed electromagnetic radiation and by spatially focusing the spectrally dispersed electromagnetic radiation through the scattering medium to the object. The method comprises forming an image of at least a portion of the emitted electromagnetic radiation propagating along a detection axis, wherein the detection axis and the illumination axis are non-collinear, and sensing the formed image. The object and/or the scattering medium may comprise biological material, for example human or animal tissue. The method may be used for light-sheet imaging in vivo or in vitro. A system for use in light-sheet imaging of an object through a scattering medium is configured to perform the method.
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公开(公告)号：US11287383B2
公开(公告)日：2022-03-29
申请号：US16333192
申请日：2017-09-13
发明人： Kishan Dholakia , Mingzhou Chen
摘要： A Raman system for use in performing Raman spectroscopy on a sample, comprises an optical source, a spectrometer, and an optical system for coupling light from the optical source to a sample and for coupling light from the sample to the spectrometer and a further spectrometer. A Raman system for use in performing Raman spectroscopy on a sample, comprises an optical source, a spectrometer and an optical system for coupling light from the optical source and a further optical source to a sample and for coupling light from the sample to the spectrometer. The optical system may be configured for coupling light from the optical source and the further optical source to the sample and for coupling light from the sample to the spectrometer and the further spectrometer. The Raman system may be portable and/or may be configured to be transported and/or carried and/or may be handheld.
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公开(公告)号：US10942023B2
公开(公告)日：2021-03-09
申请号：US16044005
申请日：2018-07-24
发明人： Kishan Dholakia , Mingzhou Chen
IPC分类号： G01B9/02
摘要： An optical coherence tomography system for imaging a sample is configured so as to illuminate a region of interest of the sample with incident light from an optical source. The optical coherence tomography system is further configured so as to interfere, on an optical detector, reference light from the optical source with offset returning light emerging from the sample along an offset collection path which is spatially offset from the region of interest of the sample, thereby creating interference on the optical detector.
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