APOLIPOPROTEIN AIV AS AN ANTIDIABETIC PEPTIDE
    1.
    发明申请
    APOLIPOPROTEIN AIV AS AN ANTIDIABETIC PEPTIDE 有权
    APOLIPOPROTEIN AIV作为抗真菌肽

    公开(公告)号:US20150252095A1

    公开(公告)日:2015-09-10

    申请号:US14704418

    申请日:2015-05-05

    Abstract: Methods for treating type two diabetes mellitus in a subject in need thereof and pharmaceutical compositions for the treatment of type two diabetes mellitus are disclosed. The methods include administering an effective amount of apolipoprotein A-IV to the subject. The pharmaceutical composition includes apolipoprotein A-IV formulated for administration to a subject for the treatment of type two diabetes mellitus. Also disclosed are methods for substantially restoring glucose tolerance in a subject in need thereof to a normal level and methods for lowering blood glucose levels in a subject in need thereof.

    Abstract translation: 公开了在有需要的受试者中治疗2型糖尿病的方法和用于治疗2型糖尿病的药物组合物。 所述方法包括向受试者施用有效量的载脂蛋白A-IV。 药物组合物包括配制用于给予受试者用于治疗2型糖尿病的载脂蛋白A-IV。 还公开了将有需要的受试者的葡萄糖耐量基本上恢复到正常水平的方法和用于降低有需要的受试者血糖水平的方法。

    METHOD OF TREATING HYPERGLYCEMIC DISORDERS USING APOLIPOPROTEIN AIV
    2.
    发明申请
    METHOD OF TREATING HYPERGLYCEMIC DISORDERS USING APOLIPOPROTEIN AIV 审中-公开
    使用APOLIPOPROTEIN AIV治疗高血压疾病的方法

    公开(公告)号:US20150182591A1

    公开(公告)日:2015-07-02

    申请号:US14416541

    申请日:2012-11-21

    CPC classification number: A61K38/22 A61K38/1709 C07K14/775

    Abstract: Methods for treating hyperglycemia disorders in a subject in need thereof and pharmaceutical compositions for the treatment of hyperglycemia disorders are disclosed. The methods include administering an effective amount of apolipoprotein A-IV to the subject. Also disclosed are methods for substantially restoring glucose tolerance in a subject in need thereof to a normal level and methods for lowering blood glucose levels in a subject having hyperglycemic disorders, including insulin resistant disorders, such as prediabetes, metabolic syndrome, polycystic ovary disease, type A syndrome, gestational diabetes, and endocrine conditions associated with hyperglycemia, including Cushing's Disease, glucagon excess (glucagon secreting tumors) and acromegaly.

    Abstract translation: 公开了在有需要的受试者中治疗高血糖病症的方法和用于治疗高血糖症的药物组合物。 所述方法包括向受试者施用有效量的载脂蛋白A-IV。 还公开了用于将有需要的受试者的葡萄糖耐量基本上恢复到正常水平的方法,以及用于降低患有高血糖病症的受试者中的血糖水平的方法,所述方法包括胰岛素抵抗障碍,例如糖尿病前期,代谢综合征,多囊卵巢疾病,类型 与高血糖相关的综合征,妊娠糖尿病和内分泌疾病,包括库欣氏病,胰高血糖素过量(胰高血糖素分泌性肿瘤)和肢端肥大症。

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