公开(公告)号：US20160345941A1

公开(公告)日：2016-12-01

申请号：US15236552

申请日：2016-08-15

Applicant: University of Florida Research Foundation, Inc.

Inventor： Kyle Douglas Allen ,  Jon Paul Dobson ,  Elena Georgina Yarmola ,  Zachary Kaufman ,  David P. Arnold

IPC: A61B10/02 ,  G01N33/543 ,  G01N33/68 ,  A61B17/52 ,  A61B17/34

Abstract: Provided herein is a magnetic apparatus for collecting superparamagnetic particles from a subject. The superparamagnetic particles are previously injected into the subject and have ligands bound thereto that are specific for one or more non-cell biomarkers. In one embodiment, the superparamagnetic particles are injected into and retrieved from a cavity such as a joint cavity. These compositions and methods allow for the sequestration and removal of inflammatory mediators, as both a diagnostic of the local immune response and a therapeutic that can reduce inflammation in the local disease environment.

Abstract translation: 本文提供了一种用于从受试者收集超顺磁性颗粒的磁性装置。 超顺磁性颗粒预先注射到受试者中并且具有与一种或多种非细胞生物标志物特异性结合的配体。 在一个实施例中，超顺磁性颗粒被注入并从诸如关节腔的空腔中取出。 这些组合物和方法允许螯合和除去炎症介质，既是局部免疫应答的诊断，也是可以减少局部疾病环境中的炎症的治疗剂。

公开(公告)号：US20140052020A1

公开(公告)日：2014-02-20

申请号：US13967571

申请日：2013-08-15

Applicant: University of Florida Research Foundation, Inc.

Inventor： Kyle Douglas Allen ,  Jon Paul Dobson ,  Elena Georgina Yarmola ,  Zachary Kaufman ,  David P. Arnold

IPC: A61B10/00

CPC classification number: A61B10/02 ,  A61B10/00 ,  A61B10/0045 ,  A61B17/3421 ,  A61B17/52 ,  G01N33/54326 ,  G01N33/6887 ,  G01N2333/78 ,  G01N2800/102 ,  G01N2800/105 ,  Y10T29/49

Abstract: Provided herein is a magnetic apparatus for collecting superparamagnetic particles from a subject. The superparamagnetic particles are previously injected into the subject and have ligands bound thereto that are specific for one or more non-cell biomarkers. In one embodiment, the superparamagnetic particles are injected into and retrieved from a cavity such as a joint cavity. These compositions and methods allow for the sequestration and removal of inflammatory mediators, as both a diagnostic of the local immune response and a therapeutic that can reduce inflammation in the local disease environment.

Abstract translation: 本文提供了一种用于从受试者收集超顺磁性颗粒的磁性装置。 超顺磁性颗粒预先注射到受试者中并且具有与一种或多种非细胞生物标志物特异性结合的配体。 在一个实施例中，超顺磁性颗粒被注入并从诸如关节腔的空腔中取出。 这些组合物和方法允许螯合和除去炎症介质，既是局部免疫应答的诊断，也是可以减少局部疾病环境中的炎症的治疗剂。

公开(公告)号：US10695036B2

公开(公告)日：2020-06-30

申请号：US15236552

申请日：2016-08-15

Applicant: University of Florida Research Foundation, Inc.

Inventor： Kyle Douglas Allen ,  Jon Paul Dobson ,  Elena Georgina Yarmola ,  Zachary Kaufman ,  David P. Arnold

IPC: A61B10/02 ,  A61B10/00 ,  G01N33/543 ,  A61B17/34 ,  A61B17/52 ,  G01N33/68

Abstract: Provided herein is a magnetic apparatus for collecting superparamagnetic particles from a subject. The superparamagnetic particles are previously injected into the subject and have ligands bound thereto that are specific for one or more non-cell biomarkers. In one embodiment, the superparamagnetic particles are injected into and retrieved from a cavity such as a joint cavity. These compositions and methods allow for the sequestration and removal of inflammatory mediators, as both a diagnostic of the local immune response and a therapeutic that can reduce inflammation in the local disease environment.