公开(公告)号：US20190216756A1

公开(公告)日：2019-07-18

申请号：US16366094

申请日：2019-03-27

Applicant: University of Houston System

Inventor： Jeffrey D. Rimer ,  Jihae Chung ,  John Asplin

IPC: A61K31/194 ,  A61K45/06 ,  C07C59/245

CPC classification number: A61K31/194 ,  A61K45/06 ,  C07C59/245

Abstract: In an embodiment of the present disclosure, there is provided a composition for dissolving calcium oxalate crystals thereby inhibiting/preventing further growth of crystals. In some embodiments, such a composition comprises at least one stereoisomer of hydroxycitrate, a derivative of the organic acid citrate. Such a method comprises administering to the subject an effective amount of the aforementioned composition. In another embodiment, the present disclosure pertains to a method of treating kidney stone disorder. Such a method comprises administering to a subject in need thereof a therapeutically effective amount of the aforementioned composition. In yet another embodiment, the present disclosure relates to a method of treating calcium oxalate stone disease. In an embodiment, the method comprises administering to a subject in need thereof a therapeutically effective amount of the aforementioned composition.