公开(公告)号：US12180165B2

公开(公告)日：2024-12-31

申请号：US17472371

申请日：2021-09-10

Applicant: University of Kansas

Inventor： Sunil A. David ,  Mallesh Beesu ,  Giuseppe Caruso ,  Alex Salyer

IPC: C07D215/38 ,  A61K45/06 ,  A61P37/02 ,  A61K39/39

Abstract: The disclosure provides human toll-like receptor modulators of general Formula (II), wherein R1, R2, R3, R4, R5, R6, R7, R8 are defined herein.

公开(公告)号：US20180258045A1

公开(公告)日：2018-09-13

申请号：US15754193

申请日：2016-08-19

Applicant: UNIVERSITY OF KANSAS

Inventor： Sunil A. David ,  Mallesh Beesu ,  Giuseppe Caruso ,  Alex Salyer

IPC: C07D215/38 ,  A61P37/02

CPC classification number: C07D215/38 ,  A61K39/39 ,  A61K45/06 ,  A61P37/02

Abstract: The disclosure provides human toll-like receptor modulators of general Formula (II), wherein R1, R2, R3, R4, R5, R6, R7, R8 are defined herein.

公开(公告)号：US10471139B2

公开(公告)日：2019-11-12

申请号：US14909967

申请日：2014-08-15

Applicant: The University of Kansas

Inventor： Sunil Abraham David ,  Euna Yoo ,  Nikunj Shukla ,  Alex Christopher Salyer ,  Mallesh Beesu ,  Subbalakshmi S. Malladi ,  Cassandra Jones

IPC: C07D471/04 ,  A61K39/39 ,  C07D235/30 ,  A61K39/00

Abstract: Compounds described herein can be used for therapeutic purposes. The compounds can be TLR agonists, such as TLR7 or TLR8 agonists. The compounds can be included in pharmaceutical compositions and used for therapies were being a TLR agonist is useful. The pharmaceutical compositions can include any ingredients, such as carries, diluents, excipients, fillers or the like that are common in pharmaceutical compositions. The compounds can be those illustrated or described herein as well as derivative thereof, prodrug thereof, salt thereof, or stereoisomer thereof, or having any chirality at any chiral center, or tautomer, polymorph, solvate, or combinations thereof. As such, the compounds can be used as adjuvants in vaccines as well as for other therapeutic purposes described herein. The compounds can have any one of the formulae. Examples of the compounds can be reviewed in Table 1 and Table A1 for activates.

公开(公告)号：US20220002251A1

公开(公告)日：2022-01-06

申请号：US17472371

申请日：2021-09-10

Applicant: University of Kansas

Inventor： Sunil A. David ,  Mallesh Beesu ,  Giuseppe Caruso ,  Alex Salyer

IPC: C07D215/38 ,  A61K45/06 ,  A61P37/02

Abstract: The disclosure provides human toll-like receptor modulators of general Formula (II), wherein R1, R2, R3, R4, R5, R6, R7, R8 are defined herein.

公开(公告)号：US11130736B2

公开(公告)日：2021-09-28

申请号：US15754193

申请日：2016-08-19

Applicant: UNIVERSITY OF KANSAS

Inventor： Sunil A. David ,  Mallesh Beesu ,  Giuseppe Caruso ,  Alex Salyer

IPC: C07D215/38 ,  A61P37/02 ,  A61K45/06 ,  A61K39/39

Abstract: The disclosure provides human toll-like receptor modulators of general Formula (II), wherein R1, R2, R3, R4, R5, R6, R7, R8 are defined herein.