公开(公告)号：US20180050081A1

公开(公告)日：2018-02-22

申请号：US15113732

申请日：2015-01-23

Applicant: The University of Kansas

Inventor： Peter S. N. Rowe ,  Aline Martin ,  Nicolae Valentin David ,  M. Laird Forrest ,  Kenneth Ryan Moulder ,  Shuang Cai ,  Daniel J. Aires

IPC: A61K38/16 ,  A61K47/69 ,  A61K31/506 ,  A61K31/58 ,  A61K9/00 ,  A61K9/107 ,  A61K8/64 ,  A61Q7/00

CPC classification number: A61K38/16 ,  A61K8/14 ,  A61K8/64 ,  A61K9/0014 ,  A61K9/1075 ,  A61K9/127 ,  A61K31/506 ,  A61K31/58 ,  A61K45/06 ,  A61K47/10 ,  A61K47/6911 ,  A61K2800/412 ,  A61Q7/00 ,  A61K2300/00

Abstract: A method of promoting hair growth can include: a polypeptide having a sequence that has at least 75% complementarity to or at least 75% identical to SPR4; and topically administering the polypeptide to a subject. This can include putting or causing the polypeptide to be in the skin, such as in any dermal layer. In one aspect, the method can include administering the composition topically so as to administer the polypeptide to the subject. In one aspect, the method can include administering the polypeptide to skin of the subject. In one aspect, the method can include administering the polypeptide to a hair follicle of the subject. In one aspect, the method can include administering the polypeptide to a bald spot of the subject.

公开(公告)号：US10350263B2

公开(公告)日：2019-07-16

申请号：US16275069

申请日：2019-02-13

Applicant: The University of Kansas

Inventor： Peter S. N. Rowe ,  Aline Martin ,  Nicolae Valentin David ,  M. Laird Forrest ,  Kenneth Ryan Moulder ,  Shuang Cai ,  Daniel J. Aires

IPC: A61K38/00 ,  A61K38/16 ,  A61K8/64 ,  A61K8/14 ,  A61K47/10 ,  A61K45/06 ,  A61K31/58 ,  A61K9/00 ,  A61K9/127 ,  A61K9/107 ,  A61Q7/00 ,  A61K31/506 ,  A61K47/69

Abstract: A method of promoting hair growth can include: a polypeptide having a sequence that has at least 75% complementarity to or at least 75% identical to SPR4; and topically administering the polypeptide to a subject. This can include putting or causing the polypeptide to be in the skin, such as in any dermal layer. In one aspect, the method can include administering the composition topically so as to administer the polypeptide to the subject. In one aspect, the method can include administering the polypeptide to skin of the subject. In one aspect, the method can include administering the polypeptide to a hair follicle of the subject. In one aspect, the method can include administering the polypeptide to a bald spot of the subject.

公开(公告)号：US20190167757A1

公开(公告)日：2019-06-06

申请号：US16275069

申请日：2019-02-13

Applicant: The University of Kansas

Inventor： Peter S. N. Rowe ,  Aline Martin ,  Nicolae Valentin David ,  M. Laird Forrest ,  Kenneth Ryan Moulder ,  Shuang Cai ,  Daniel J. Aires

IPC: A61K38/16 ,  A61K8/64 ,  A61K8/14 ,  A61K47/10 ,  A61K45/06 ,  A61K31/58 ,  A61K47/69 ,  A61K9/00 ,  A61K9/127 ,  A61K9/107 ,  A61Q7/00 ,  A61K31/506

CPC classification number: A61K38/16 ,  A61K8/14 ,  A61K8/64 ,  A61K9/0014 ,  A61K9/1075 ,  A61K9/127 ,  A61K31/506 ,  A61K31/58 ,  A61K45/06 ,  A61K47/10 ,  A61K47/6911 ,  A61K2800/412 ,  A61Q7/00 ,  A61K2300/00

Abstract: A method of promoting hair growth can include: a polypeptide having a sequence that has at least 75% complementarity to or at least 75% identical to SPR4; and topically administering the polypeptide to a subject. This can include putting or causing the polypeptide to be in the skin, such as in any dermal layer. In one aspect, the method can include administering the composition topically so as to administer the polypeptide to the subject. In one aspect, the method can include administering the polypeptide to skin of the subject. In one aspect, the method can include administering the polypeptide to a hair follicle of the subject. In one aspect, the method can include administering the polypeptide to a bald spot of the subject.

公开(公告)号：US10857199B2

公开(公告)日：2020-12-08

申请号：US16444829

申请日：2019-06-18

Applicant: The University of Kansas

Inventor： Peter S. N. Rowe ,  Aline Martin ,  Nicolae Valentin David ,  M. Laird Forrest ,  Kenneth Ryan Moulder ,  Shuang Cai ,  Daniel J. Aires

IPC: A61K38/00 ,  A61K38/16 ,  A61K9/00 ,  A61K9/107 ,  A61K9/127 ,  A61K8/64 ,  A61Q7/00 ,  A61K8/14 ,  A61K45/06 ,  A61K31/506 ,  A61K31/58 ,  A61K47/10 ,  A61K47/69

Abstract: A method of promoting hair growth can include: a polypeptide having a sequence that has at least 75% complementarity to or at least 75% identical to SPR4; and topically administering the polypeptide to a subject. This can include putting or causing the polypeptide to be in the skin, such as in any dermal layer. In one aspect, the method can include administering the composition topically so as to administer the polypeptide to the subject. In one aspect, the method can include administering the polypeptide to skin of the subject. In one aspect, the method can include administering the polypeptide to a hair follicle of the subject. In one aspect, the method can include administering the polypeptide to a bald spot of the subject.

公开(公告)号：US20240398895A1

公开(公告)日：2024-12-05

申请号：US18737680

申请日：2024-06-07

Applicant: University of Kansas

Inventor： Peter S. N. Rowe

IPC: A61K38/17 ,  A61P13/12

Abstract: A method of treating or inhibiting a kidney disorder can include administering a therapeutically effective amount of the ASARM peptide to provide a treatment for the kidney disorder (treat disease) and/or inhibit development of the kidney disorder (prophylactic). The kidney disorder can be selected from the group consisting of chronic kidney disease mineral bone disorder (CKD-MBD), calciphylaxis, nephrogenic systemic fibrosis (NSF), end stage renal disease, and combinations thereof. The therapy can include inhibiting vascular calcification (VC), hard tissue calcification, soft tissue calcification, mineralization, or combinations thereof in the subject with the ASARM peptide. A method of inhibiting mineralization can include administering a therapeutically effective amount of the ASARM peptide to provide a treatment for inhibit mineralization in the subject. A method of treating hyperphosphatemia can include administering a therapeutically effective amount of the ASARM peptide to a subject to provide a treatment for hyperphosphatemia.

公开(公告)号：US20220105151A1

公开(公告)日：2022-04-07

申请号：US17495556

申请日：2021-10-06

Applicant: The University of Kansas

Inventor： Peter S. N. Rowe

IPC: A61K38/17 ,  A61P13/12

Abstract: A method of treating or inhibiting a kidney disorder can include administering a therapeutically effective amount of the ASARM peptide to provide a treatment for the kidney disorder (treat disease) and/or inhibit development of the kidney disorder (prophylactic). The kidney disorder can be selected from the group consisting of chronic kidney disease mineral bone disorder (CKD-MBD), calciphylaxis, nephrogenic systemic fibrosis (NSF), end stage renal disease, and combinations thereof. The therapy can include inhibiting vascular calcification (VC), hard tissue calcification, soft tissue calcification, mineralization, or combinations thereof in the subject with the ASARM peptide. A method of inhibiting mineralization can include administering a therapeutically effective amount of the ASARM peptide to provide a treatment for inhibit mineralization in the subject. A method of treating hyperphosphatemia can include administering a therapeutically effective amount of the ASARM peptide to a subject to provide a treatment for hyperphosphatemia.

公开(公告)号：US20200101132A1

公开(公告)日：2020-04-02

申请号：US16444829

申请日：2019-06-18

Applicant: The University of Kansas

Inventor： Peter S. N. Rowe ,  Aline Martin ,  Nicolae Valentin David ,  M. Laird Forrest ,  Kenneth Ryan Moulder ,  Shuang Cai ,  Daniel J. Aires

IPC: A61K38/16 ,  A61K9/00 ,  A61K9/107 ,  A61K9/127 ,  A61K8/64 ,  A61Q7/00 ,  A61K8/14 ,  A61K45/06 ,  A61K31/506 ,  A61K31/58 ,  A61K47/10 ,  A61K47/69

Abstract: A method of promoting hair growth can include: a polypeptide having a sequence that has at least 75% complementarity to or at least 75% identical to SPR4; and topically administering the polypeptide to a subject. This can include putting or causing the polypeptide to be in the skin, such as in any dermal layer. In one aspect, the method can include administering the composition topically so as to administer the polypeptide to the subject. In one aspect, the method can include administering the polypeptide to skin of the subject. In one aspect, the method can include administering the polypeptide to a hair follicle of the subject. In one aspect, the method can include administering the polypeptide to a bald spot of the subject.