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公开(公告)号:US11286462B2
公开(公告)日:2022-03-29
申请号:US16647345
申请日:2018-09-14
申请人: University of Kansas
发明人: Hiroshi Nishimune , Richard Barohn , Buddhadeb Dawn , Yomna Badawi , James W. Mitchell , Rupal Soder
IPC分类号: C12N5/0775 , A61K35/51
摘要: Embodiments of the present disclosure relate generally to the production of therapeutic mesenchymal stem cells (MSCs). More particularly, the present disclosure relates to the use of cell culture compositions and methods for generating MSCs that secrete neurotrophic factors and synaptic organizing agents for the treatment of neurodegenerative diseases such as Amyotrophic Lateral Sclerosis (ALS). As such, the present disclosure addresses the need for establishing a reliable source of therapeutic stem cells useful for the treatment of neurodegenerative diseases.
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公开(公告)号:US20220396772A1
公开(公告)日:2022-12-15
申请号:US17582704
申请日:2022-01-24
申请人: University of Kansas
发明人: Hiroshi Nishimune , Richard Barohn , Buddhadeb Dawn , Yomna Badawi , James W. Mitchell , Rupal Soder
IPC分类号: C12N5/0775 , A61K35/51
摘要: Embodiments of the present disclosure relate generally to the production of therapeutic mesenchymal stem cells (MSCs). More particularly, the present disclosure relates to the use of cell culture compositions and methods for generating MSCs that secrete neurotrophic factors and synaptic organizing agents for the treatment of neurodegenerative diseases such as Amyotrophic Lateral Sclerosis (ALS). As such, the present disclosure addresses the need for establishing a reliable source of therapeutic stem cells useful for the treatment of neurodegenerative diseases.
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