公开(公告)号：US12098382B2

公开(公告)日：2024-09-24

申请号：US17333904

申请日：2021-05-28

申请人： University of Maryland, College Park

发明人： Daniel R. Perez ,  Hongjun Chen ,  Yibin Cai ,  Lindomar Jose Pena ,  Matthew Angel

IPC分类号： C12N15/86 ,  A61K39/12 ,  A61K39/145 ,  C12N7/00 ,  A61K39/00

CPC分类号： C12N15/86 ,  A61K39/12 ,  A61K39/145 ,  C12N7/00 ,  A61K2039/525 ,  A61K2039/543 ,  A61K2039/70 ,  C12N2760/16122 ,  C12N2760/16134 ,  C12N2760/16143 ,  C12N2760/16151 ,  C12N2760/16162

摘要： Disclosed are compositions and methods comprising one or more recombinant influenza viruses. Recombinant influenza viruses with mutated polymerases and/or rearranged genomes are disclosed. Constructs comprising different influenza nucleic acid sequences are also provided. Methods of inducing protecting immunity with the recombinant influenza viruses are disclosed. Also disclosed are methods of plasmid-free production of influenza virus comprising amplicons comprising one or more of influenza genes.

公开(公告)号：US20220119839A1

公开(公告)日：2022-04-21

申请号：US17333904

申请日：2021-05-28

申请人： University of Maryland, College Park

发明人： Daniel R. Perez ,  Hongjun Chen ,  Yibin Cai ,  Lindomar Jose Pena ,  Matthew Angel

IPC分类号： C12N15/86 ,  A61K39/12 ,  A61K39/145 ,  C12N7/00

摘要： Disclosed are compositions and methods comprising one or more recombinant influenza viruses. Recombinant influenza viruses with mutated polymerases and/or rearranged genomes are disclosed. Constructs comprising different influenza nucleic acid sequences are also provided. Methods of inducing protecting immunity with the recombinant influenza viruses are disclosed. Also disclosed are methods of plasmid-free production of influenza virus comprising amplicons comprising one or more of influenza genes.

公开(公告)号：US11028408B2

公开(公告)日：2021-06-08

申请号：US13903891

申请日：2013-05-28

申请人： University of Maryland, College Park

发明人： Daniel R. Perez ,  Hongjun Chen ,  Yibin Cai ,  Lindomar Jose Pena ,  Matthew Angel

IPC分类号： C12N15/86 ,  A61K38/45 ,  A61P9/00 ,  A61K39/12 ,  A61K39/145 ,  C12N7/00 ,  A61K39/00

摘要： Disclosed are compositions and methods comprising one or more recombinant influenza viruses. Recombinant influenza viruses with mutated polymerases and/or rearranged genomes are disclosed. Constructs comprising different influenza nucleic acid sequences are also provided. Methods of inducing protecting immunity with the recombinant influenza viruses are disclosed. Also disclosed are methods of plasmid-free production of influenza virus comprising amplicons comprising one or more of influenza genes.