公开(公告)号：US20240123062A1

公开(公告)日：2024-04-18

申请号：US18471955

申请日：2023-09-21

申请人： University of Massachusetts

发明人： Daniel H. Libraty

IPC分类号： A61K39/295 ,  A61K39/12 ,  A61K39/29 ,  A61K47/65 ,  A61P31/14 ,  A61P31/20

CPC分类号： A61K39/295 ,  A61K39/12 ,  A61K39/292 ,  A61K47/65 ,  A61P31/14 ,  A61P31/20

摘要： The present invention relates to the construction of and immunization with viral vaccines. In particular, bivalent vaccines that are capable of providing simultaneous virus infection protection for two or more different viruses. Furthermore, the bivalent vaccines contemplated herein are contemplated as being effective in a neonatal mammal. One such bivalent viral vaccine comprises two antigenic epitopes against the dengue viruses and at least one antigenic epitope against hepatitis B virus. Immunization cross-reactivity may also provide infection protection against other viruses as well.

公开(公告)号：US11793873B2

公开(公告)日：2023-10-24

申请号：US16612152

申请日：2018-05-01

申请人： UNIVERSITY OF MASSACHUSETTS

发明人： Daniel H. Libraty

IPC分类号： A61K39/00 ,  A61K39/295 ,  A61K47/65 ,  A61P31/20 ,  A61P31/14 ,  A61K39/12 ,  A61K39/29

CPC分类号： A61K39/295 ,  A61K39/12 ,  A61K39/292 ,  A61K47/65 ,  A61P31/14 ,  A61P31/20

摘要： The present invention relates to the construction of, and immunization with viral vaccines. In particular, bivalent vaccines that are capable of providing simultaneous virus infection protection for two or more different viruses. Furthermore, the bivalent vaccines contemplated herein are contemplated as being effective in a neonatal mammal. One such bivalent viral vaccine comprises two antigenic epitopes against the dengue viruses and at least one antigenic epitope against hepatitis B virus. Immunization cross-reactivity may also provide infection protection against other viruses as well.

公开(公告)号：US20210379182A1

公开(公告)日：2021-12-09

申请号：US16612152

申请日：2018-05-01

申请人： UNIVERSITY OF MASSACHUSETTS

发明人： Daniel H. Libraty

IPC分类号： A61K39/295 ,  A61K39/12 ,  A61K47/65 ,  A61K39/29 ,  A61P31/20 ,  A61P31/14

摘要： The present invention relates to the construction of, and immunization with viral vaccines. In particular, bivalent vaccines that are capable of providing simultaneous virus infection protection for two or more different viruses. Furthermore, the bivalent vaccines contemplated herein are contemplated as being effective in a neonatal mammal. One such bivalent viral vaccine comprises two antigenic epitopes against the dengue viruses and at least one antigenic epitope against hepatitis B virus. Immunization cross-reactivity may also provide infection protection against other viruses as well.