公开(公告)号：US11884926B2

公开(公告)日：2024-01-30

申请号：US16966504

申请日：2019-02-01

Applicant: University of Massachusetts

Inventor： Terence Flotte ,  Qiushi Tang ,  Allison Keeler-Klunk ,  Qin Su

IPC: C12N15/70 ,  C12N7/00

CPC classification number: C12N15/70 ,  C12N7/00 ,  C12N2750/14143 ,  C12N2750/14151 ,  C12N2750/14171

Abstract: In some aspects, the disclosure relates to compositions and methods for production of recombinant adeno-associated virus (rAAV) particles. The disclosure is based, in part, on isolated nucleic acids and systems that include only two vectors and are suitable for production of multiple different single gene viral vectors in a multiple small-scale campaign mode (e.g., 1013 to 1016 viral particles.)

公开(公告)号：US20210047650A1

公开(公告)日：2021-02-18

申请号：US16966504

申请日：2019-02-01

Applicant: University of Massachusetts

Inventor： Terence Flotte ,  Qiushi Tang ,  Allison Keeler-Klunk ,  Qin Su

IPC: C12N15/70 ,  C12N7/00

Abstract: In some aspects, the disclosure relates to compositions and methods for production of recombinant adeno-associated virus (rAAV) particles. The disclosure is based, in part, on isolated nucleic acids and systems that include only two vectors and are suitable for production of multiple different single gene viral vectors in a multiple small-scale campaign mode (e.g., 1013 to 1016 viral particles.)