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公开(公告)号：US11311506B2
公开(公告)日：2022-04-26
申请号：US16670802
申请日：2019-10-31
摘要： Compositions and methods for using cyclopropanated structural analogs of fatty acid biofilm dispersal agents are characterized by superior biofilm dispersion. When used in combination with antimicrobials, these analogs decrease the minimum inhibitory concentration of antimicrobial agents required for eradication of the biofilm and/or treatment of infection. Methods for using these analogs include direct application to a surface, blending with lipid based carriers, or covalent anchoring the molecule to a surface. Typically, the cyclopropanated structural analog has the structure according to formula (I): wherein R1 is a C1-C24 linear or branched alkyl group; or an acid halide or acid anhydride thereof.
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公开(公告)号：US08969590B1
公开(公告)日：2015-03-03
申请号：US13622018
申请日：2012-09-18
IPC分类号： C07D471/04 , C07D209/48 , C07D401/14
CPC分类号： C07D471/04 , A61K31/517 , A61K31/558 , C07D209/48 , C07D401/14
摘要： Classes of compounds that exhibit effective inhibition of autotaxin enzymes are provided. Such classes include thioureas, diphenyldiazerenes, xanthenes, and isoindoles and exhibit reactivity with autotaxin to ultimately reduce the size of the reactive sites thereon to prevent conversion of lysophosphatidyl choline to lysophophatidic acid. Furthermore, such compounds can be incorporated within delivery forms for human ingestion. As such, these compounds accord an excellent manner of potentially reducing generation of certain cancers attributable to the presence of naturally occurring autotaxin within the human body. Methods of inactivating autotaxin to certain degrees therewith such compounds are encompassed within invention as well.
摘要翻译： 提供表现出有效抑制自体素蛋白酶的化合物类别。 这些类别包括硫脲，二苯基二氮杂，呫吨和异吲哚，并表现出与自分泌素的反应性，以最终减小其上的反应位点的大小，以防止溶血磷脂酰胆碱转化成溶血磷脂酸。 此外，这些化合物可以并入用于人体摄取的递送形式中。 因此，这些化合物具有潜在地减少由于天然存在的自体贴剂在人体内的存在而导致某些癌症的产生的优异方式。 使用这种化合物将自分生菌素灭活至一定程度的方法也包括在本发明范围内。
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