专利检索 ap:("University of Pittsburgh—Of the Commonwealth System of Higher Education") AND inv:"Branimir Popovic" 第 1 页

1.

发明授权
Methods of engineering human induced pluripotent stem cells to produce liver tissue 有权

公开(公告)号：US11530388B2

公开(公告)日：2022-12-20

申请号：US16485771

申请日：2018-02-13

申请人： University of Pittsburgh—Of the Commonwealth System of Higher Education

发明人： Alejandro Soto-Gutierrez , Tomoji Mashimo , Alexandra Sylvie Collin de l'Hortet , Eduardo Cervantes Alvarez , Jorge Guzman Lepe , Kan Handa , Kazuki Takeishi , Yang Wang , Branimir Popovic

IPC分类号： C12N5/00 , C12N5/071 , A01K67/027 , C12N5/074

摘要： Methods are disclosed herein for producing human hepatocytes from human induced pluripotent stem cells. Also provided are transgenic rats for the expansion of human hepatocytes, such as those produced using the methods disclosed herein.