公开(公告)号：US11850141B2

公开(公告)日：2023-12-26

申请号：US16577579

申请日：2019-09-20

申请人： University of Pittsburgh—Of the Commonwealth System of Higher Education

发明人： Mohammed S. El-Kurdi ,  William R. Wagner ,  David A. Vorp ,  John J. Stankus ,  Lorenzo Soletti ,  Jonathan McGrath ,  Yi Hong ,  J Christopher Flaherty

IPC分类号： A61F2/06 ,  A61F2/04 ,  A61F2/07

CPC分类号： A61F2/06 ,  A61F2/04 ,  A61F2/062 ,  A61F2002/072

摘要： A tubular tissue graft device is provided comprising a tubular member and a restrictive fiber matrix of a bioerodible polymer about a circumference of the tubular tissue. The matrix may be electrospun onto the tubular tissue. In one embodiment, the tubular tissue is from a vein, such as a saphenous vein, useful as an arterial graft, for example and without limitation, in a coronary artery bypass procedure. Also provided is method of preparing a tubular graft comprising depositing a fiber matrix of a bioerodible polymer about a perimeter of a tubular tissue to produce a tubular tissue graft device. A cardiac bypass method comprising bypassing a coronary artery with a tubular tissue graft device comprising a vein and a restrictive fiber matrix of a bioerodible polymer about a circumference of the vein also is provided.