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公开(公告)号：US11850141B2
公开(公告)日：2023-12-26
申请号：US16577579
申请日：2019-09-20
发明人： Mohammed S. El-Kurdi , William R. Wagner , David A. Vorp , John J. Stankus , Lorenzo Soletti , Jonathan McGrath , Yi Hong , J Christopher Flaherty
CPC分类号： A61F2/06 , A61F2/04 , A61F2/062 , A61F2002/072
摘要： A tubular tissue graft device is provided comprising a tubular member and a restrictive fiber matrix of a bioerodible polymer about a circumference of the tubular tissue. The matrix may be electrospun onto the tubular tissue. In one embodiment, the tubular tissue is from a vein, such as a saphenous vein, useful as an arterial graft, for example and without limitation, in a coronary artery bypass procedure. Also provided is method of preparing a tubular graft comprising depositing a fiber matrix of a bioerodible polymer about a perimeter of a tubular tissue to produce a tubular tissue graft device. A cardiac bypass method comprising bypassing a coronary artery with a tubular tissue graft device comprising a vein and a restrictive fiber matrix of a bioerodible polymer about a circumference of the vein also is provided.
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公开(公告)号：US20200237494A1
公开(公告)日：2020-07-30
申请号：US16577579
申请日：2019-09-20
发明人： Mohammed S. El-Kurdi , William R. Wagner , David A. Vorp , John J. Stankus , Lorenzo Soletti , Jonathan McGrath , Yi Hong , J. Christopher Flaherty
IPC分类号： A61F2/06
摘要： A tubular tissue graft device is provided comprising a tubular member and a restrictive fiber matrix of a bioerodible polymer about a circumference of the tubular tissue. The matrix may be electrospun onto the tubular tissue. In one embodiment, the tubular tissue is from a vein, such as a saphenous vein, useful as an arterial graft, for example and without limitation, in a coronary artery bypass procedure. Also provided is method of preparing a tubular graft comprising depositing a fiber matrix of a bioerodible polymer about a perimeter of a tubular tissue to produce a tubular tissue graft device. A cardiac bypass method comprising bypassing a coronary artery with a tubular tissue graft device comprising a vein and a restrictive fiber matrix of a bioerodible polymer about a circumference of the vein also is provided.
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公开(公告)号：US20170340432A1
公开(公告)日：2017-11-30
申请号：US15453115
申请日：2017-03-08
发明人： Mohammed S. El-Kurdi , J. Christopher Flaherty , Yi Hong , Jonathan McGrath , Lorenzo Soletti , John J. Stankus , David A. Vorp , William R. Wagner
CPC分类号： A61F2/06 , A61F2/04 , A61F2/062 , A61F2002/072
摘要： A tubular tissue graft device is provided comprising a tubular member and a restrictive fiber matrix of a bioerodible polymer about a circumference of the tubular tissue. The matrix may be electrospun onto the tubular tissue. In one embodiment, the tubular tissue is from a vein, such as a saphenous vein, useful as an arterial graft, for example and without limitation, in a coronary artery bypass procedure. Also provided is method of preparing a tubular graft comprising depositing a fiber matrix of a bioerodible polymer about a perimeter of a tubular tissue to produce a tubular tissue graft device. A cardiac bypass method comprising bypassing a coronary artery with a tubular tissue graft device comprising a vein and a restrictive fiber matrix of a bioerodible polymer about a circumference of the vein also is provided.
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公开(公告)号：US20160325016A1
公开(公告)日：2016-11-10
申请号：US15216878
申请日：2016-07-22
发明人： Nicholas J. Amoroso , Stephen Francis Badylak , Yi Hong , Alexander Huber , Keisuke Takanari , William R. Wagner
CPC分类号： A61L27/18 , A61L27/3633 , A61L27/48 , A61L27/58 , A61L2400/18 , A61L2430/34 , C08L67/04 , C08L75/00
摘要： A biohybrid scaffold is provided that is useful in clinical applications for abdominal wall reconstruction, pelvic floor repair, breast reconstruction, as well as other soft tissue repairs. Methods of making and using the biohybrid scaffold are provided.
摘要翻译： 提供了一种生物混合支架，可用于腹壁重建，盆底修复，乳房重建以及其他软组织修复的临床应用。 提供制造和使用生物混合支架的方法。
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公开(公告)号：US20160317280A1
公开(公告)日：2016-11-03
申请号：US15086612
申请日：2016-03-31
发明人： Mohammed S. El-Kurdi , Yi Hong , Lorenzo Soletti , John J. Stankus , David A. Vorp , William R. Wagner
CPC分类号： A61F2/06 , A61F2/07 , A61F2210/0004 , A61F2210/0076 , A61F2240/001 , A61F2250/0067 , A61L27/18 , A61L27/34 , A61L27/3625 , A61L27/3683 , A61L27/3691 , A61L27/3804 , A61L27/3826 , A61L27/507 , A61L27/54 , A61L27/58 , A61L2300/414 , A61L2300/604 , A61L2430/22 , C12N5/0068 , C12N2533/40 , D01D5/0007 , D01D5/0076 , D10B2331/10 , D10B2401/12 , D10B2509/06 , C08L67/04
摘要： A tubular tissue graft device is provided comprising a tubular tissue and a restrictive fiber matrix of a bioerodible polymer about a circumference of the tubular tissue. The matrix may be electrospun onto the tubular tissue. In one embodiment, the tubular tissue is from a vein, such as a saphenous vein, useful as an arterial graft, for example and without limitation, in a coronary artery bypass procedure. Also provided is method of preparing a tubular graft comprising depositing a fiber matrix of a bioerodible polymer about a perimeter of a tubular tissue to produce a tubular tissue graft device. A cardiac bypass method comprising bypassing a coronary artery with a tubular tissue graft device comprising a vein and a restrictive fiber matrix of a bioerodible polymer about a circumference of the vein also is provided.
摘要翻译： 提供了一种管状组织移植装置，其包括管状组织和围绕管状组织的圆周的生物可蚀解聚合物的限制性纤维基质。 基质可以电纺到管状组织上。 在一个实施例中，管状组织来自静脉，例如隐静脉，可用作动脉移植物，例如但不限于冠状动脉旁路手术。 还提供了制备管状移植物的方法，其包括围绕管状组织的周边沉积生物可蚀解聚合物的纤维基质以产生管状组织移植装置。 还提供了一种包括绕管冠状动脉的心脏旁路方法，所述管状组织移植装置包括静脉和围绕静脉周围的生物可蚀解聚合物的限制性纤维基质。
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公开(公告)号：US20190046689A1
公开(公告)日：2019-02-14
申请号：US15892481
申请日：2018-02-09
摘要： A cell growth matrix is provided that comprises a biodegradable elastomeric polymer electrodeposited concurrently with a sprayed or electrosprayed liquid that is a physiological solution or which comprises a mammalian blood product such as serum, plasma or platelet rich plasma. The matrix is useful as a cell-growth matrix and for repair of a tissue in a mammal, for instance by implantation in a mammal at a site in need of repair, such as in an abdominal wall.
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公开(公告)号：US20140248232A1
公开(公告)日：2014-09-04
申请号：US14194188
申请日：2014-02-28
发明人： Yi Hong , William R, Wagner , Sang-Ho Ye
CPC分类号： A61L33/068 , A61L27/18 , A61L27/58 , A61L31/10 , A61L31/148 , A61L31/16 , A61L33/064 , A61L2300/402 , A61L2300/404 , A61L2300/41 , A61L2300/416 , C08L67/04
摘要： A method of forming an implantable article includes providing a biodegradable polymer including anti-thrombogenic groups along the length of the biodegradable polymer, biodegradable groups in the backbone of the biodegradable polymer and a plurality of functional groups adapted to react with reactive functional groups on a surface of the implantable article, and reacting at least a portion of the plurality of functional groups with the reactive functional groups on the surface of the implantable article.
摘要翻译： 一种形成可植入物品的方法包括提供可生物降解的聚合物，其包括沿生物可降解聚合物长度的抗血栓形成基团，可生物降解聚合物主链中的可生物降解基团和适于与表面上的反应性官能团反应的多个官能团 以及使所述多个官能团的至少一部分与可植入制品的表面上的反应性官能团反应。
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公开(公告)号：US10092676B2
公开(公告)日：2018-10-09
申请号：US15216878
申请日：2016-07-22
发明人： Nicholas J. Amoroso , Stephen Francis Badylak , Yi Hong , Alexander Huber , Keisuke Takanari , William R. Wagner
摘要： A biohybrid scaffold is provided that is useful in clinical applications for abdominal wall reconstruction, pelvic floor repair, breast reconstruction, as well as other soft tissue repairs. Methods of making and using the biohybrid scaffold are provided.
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公开(公告)号：US09808560B2
公开(公告)日：2017-11-07
申请号：US14194188
申请日：2014-02-28
发明人： Yi Hong , William R Wagner , Sang-Ho Ye
CPC分类号： A61L33/068 , A61L27/18 , A61L27/58 , A61L31/10 , A61L31/148 , A61L31/16 , A61L33/064 , A61L2300/402 , A61L2300/404 , A61L2300/41 , A61L2300/416 , C08L67/04
摘要： A method of forming an implantable article includes providing a biodegradable polymer including anti-thrombogenic groups along the length of the biodegradable polymer, biodegradable groups in the backbone of the biodegradable polymer and a plurality of functional groups adapted to react with reactive functional groups on a surface of the implantable article, and reacting at least a portion of the plurality of functional groups with the reactive functional groups on the surface of the implantable article.
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公开(公告)号：US20150150673A1
公开(公告)日：2015-06-04
申请号：US14601523
申请日：2015-01-21
发明人： Mohammed S. El-Kurdi , Yi Hong , Lorenzo Soletti , John J. Stankus , David A. Vorp , William R. Wagner
CPC分类号： A61F2/06 , A61F2/07 , A61F2210/0004 , A61F2210/0076 , A61F2240/001 , A61F2250/0067 , A61L27/18 , A61L27/34 , A61L27/3625 , A61L27/3683 , A61L27/3691 , A61L27/3804 , A61L27/3826 , A61L27/507 , A61L27/54 , A61L27/58 , A61L2300/414 , A61L2300/604 , A61L2430/22 , C12N5/0068 , C12N2533/40 , D01D5/0007 , D01D5/0076 , D10B2331/10 , D10B2401/12 , D10B2509/06 , C08L67/04
摘要： A tubular tissue graft device is provided comprising a tubular tissue and a restrictive fiber matrix of a bioerodible polymer about a circumference of the tubular tissue. The matrix may be electrospun onto the tubular tissue. In one embodiment, the tubular tissue is from a vein, such as a saphenous vein, useful as an arterial graft, for example and without limitation, in a coronary artery bypass procedure. Also provided is method of preparing a tubular graft comprising depositing a fiber matrix of a bioerodible polymer about a perimeter of a tubular tissue to produce a tubular tissue graft device. A cardiac bypass method comprising bypassing a coronary artery with a tubular tissue graft device comprising a vein and a restrictive fiber matrix of a bioerodible polymer about a circumference of the vein also is provided.
摘要翻译： 提供了一种管状组织移植装置，其包括管状组织和围绕管状组织的圆周的生物可蚀解聚合物的限制性纤维基质。 基质可以电纺到管状组织上。 在一个实施例中，管状组织来自静脉，例如隐静脉，可用作动脉移植物，例如但不限于冠状动脉旁路手术。 还提供了制备管状移植物的方法，其包括围绕管状组织的周边沉积生物可蚀解聚合物的纤维基质以产生管状组织移植装置。 还提供了一种包括绕管冠状动脉的心脏旁路方法，所述管状组织移植装置包括静脉和围绕静脉周围的生物可蚀解聚合物的限制性纤维基质。
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