公开(公告)号：US11857634B2

公开(公告)日：2024-01-02

申请号：US17049152

申请日：2019-04-20

Applicant: University of Pittsburgh—Of the Commonwealth System of Higher Education

Inventor： Song Li ,  Jingjing Sun ,  Yichao Chen ,  Yixian Huang ,  Yanhua Liu ,  Binfeng Lu

IPC: A61K47/58 ,  A61K47/54 ,  A61K9/107 ,  A61K31/65 ,  C12N15/113

CPC classification number: A61K47/58 ,  A61K9/1075 ,  A61K31/65 ,  A61K47/549 ,  C12N15/113 ,  C12N2310/14 ,  C12N2310/351

Abstract: A formulation includes a plurality of polymers including a hydrophobic polymer backbone (for example, formed via radical polymerization), a first plurality of pendant groups attached to the hydrophobic polymer backbone and including at least one cationic group, and a second plurality of pendant groups attached to the hydrophobic polymer backbone and including at least one hydrophilic polymer, a first therapeutic compound, and a second therapeutic compound, wherein the second therapeutic compound is different from the first therapeutic compound and includes a nucleic acid.

公开(公告)号：US20210236645A1

公开(公告)日：2021-08-05

申请号：US17049152

申请日：2019-04-20

Applicant: University of Pittsburgh - Of the Commonwealth System of Higher Education

Inventor： Song Li ,  Jingjing Sun ,  Yichao Chen ,  Yixian Huang ,  Yanhua Liu ,  Binfeng Lu

IPC: A61K47/58 ,  A61K47/54 ,  C12N15/113 ,  A61K9/107 ,  A61K31/65

Abstract: A formulation includes a plurality of polymers including a hydrophobic polymer backbone (for example, formed via radical polymerization), a first plurality of pendant groups attached to the hydrophobic polymer backbone and including at least one cationic group, and a second plurality of pendant groups attached to the hydrophobic polymer backbone and including at least one hydrophilic polymer, a first therapeutic compound, and a second therapeutic compound, wherein the second therapeutic compound is different from the first therapeutic compound and includes a nucleic acid.

公开(公告)号：US20240131170A1

公开(公告)日：2024-04-25

申请号：US18540254

申请日：2023-12-14

Applicant: University of Pittsburgh - Of the Commonwealth System of Higher Education

Inventor： Song Li ,  Jingjing Sun ,  Yichao Chen ,  Yixian Huang ,  Yanhua Liu ,  Binfeng Lu

IPC: A61K47/58 ,  A61K9/107 ,  A61K31/65 ,  A61K47/54 ,  C12N15/113

CPC classification number: A61K47/58 ,  A61K9/1075 ,  A61K31/65 ,  A61K47/549 ,  C12N15/113 ,  C12N2310/14 ,  C12N2310/351

Abstract: A formulation includes a plurality of polymers including a hydrophobic polymer backbone (for example, formed via radical polymerization), a first plurality of pendant groups attached to the hydrophobic polymer backbone and including at least one cationic group, and a second plurality of pendant groups attached to the hydrophobic polymer backbone and including at least one hydrophilic polymer, a first therapeutic compound, and a second therapeutic compound, wherein the second therapeutic compound is different from the first therapeutic compound and includes a nucleic acid.