公开(公告)号：US20240424131A1

公开(公告)日：2024-12-26

申请号：US18692919

申请日：2022-09-19

Applicant: University of Pittsburgh - Of the Commonwealth System of Higher Education

Inventor： Song Li ,  Yixian Huang ,  Yuang Chen

IPC: A61K47/69 ,  A61K9/107 ,  A61K31/555 ,  A61K47/60 ,  A61K47/61 ,  A61P35/00 ,  C12N15/113

Abstract: A formulation includes nanostructures formed from self-assembly of a plurality of amphiphilic polymers comprising cationic groups. Each of the nanostructures includes an application thereon or added thereto. The application inc hides a negatively charged targeting agent.

公开(公告)号：US20240325565A1

公开(公告)日：2024-10-03

申请号：US18624989

申请日：2024-04-02

Applicant: University of Pittsburgh - Of the Commonwealth System of Higher Education

Inventor： Song Li ,  Jingjing Sun

IPC: A61K47/69 ,  A61K39/395 ,  A61K47/58 ,  A61K47/60

CPC classification number: A61K47/6925 ,  A61K39/3955 ,  A61K47/58 ,  A61K47/60 ,  B82Y5/00

Abstract: A formulation including a nanostructure including an agent to activate a STING pathway in vivo and a C-C chemokine receptor type 2 (CCR2) antagonist.

公开(公告)号：US11857634B2

公开(公告)日：2024-01-02

申请号：US17049152

申请日：2019-04-20

Applicant: University of Pittsburgh—Of the Commonwealth System of Higher Education

Inventor： Song Li ,  Jingjing Sun ,  Yichao Chen ,  Yixian Huang ,  Yanhua Liu ,  Binfeng Lu

IPC: A61K47/58 ,  A61K47/54 ,  A61K9/107 ,  A61K31/65 ,  C12N15/113

CPC classification number: A61K47/58 ,  A61K9/1075 ,  A61K31/65 ,  A61K47/549 ,  C12N15/113 ,  C12N2310/14 ,  C12N2310/351

Abstract: A formulation includes a plurality of polymers including a hydrophobic polymer backbone (for example, formed via radical polymerization), a first plurality of pendant groups attached to the hydrophobic polymer backbone and including at least one cationic group, and a second plurality of pendant groups attached to the hydrophobic polymer backbone and including at least one hydrophilic polymer, a first therapeutic compound, and a second therapeutic compound, wherein the second therapeutic compound is different from the first therapeutic compound and includes a nucleic acid.

公开(公告)号：US20210330808A1

公开(公告)日：2021-10-28

申请号：US17284562

申请日：2019-10-11

Applicant: University of Pittsburgh - Of the Commonwealth System of Higher Education

Inventor： Jingjing Sun ,  Song Li

IPC: A61K47/69 ,  A61K9/107 ,  A61K47/54 ,  A61K47/58 ,  A61K47/60 ,  A61K31/7068 ,  A61K31/337 ,  A61K31/436 ,  A61K38/13 ,  A61K31/366 ,  A61K31/12 ,  A61K31/405 ,  A61K31/551 ,  A61K31/138 ,  A61K31/404 ,  A61K31/506

Abstract: A polymer includes a hydrophobic polymer backbone, a first plurality of pendant groups attached to the hydrophobic polymer backbone and including at least one group including a plurality of hydroxyl groups, and a second plurality of pendant groups attached to the hydrophobic polymer backbone and comprising at least one hydrophilic polymer.

公开(公告)号：US20210236645A1

公开(公告)日：2021-08-05

申请号：US17049152

申请日：2019-04-20

Applicant: University of Pittsburgh - Of the Commonwealth System of Higher Education

Inventor： Song Li ,  Jingjing Sun ,  Yichao Chen ,  Yixian Huang ,  Yanhua Liu ,  Binfeng Lu

IPC: A61K47/58 ,  A61K47/54 ,  C12N15/113 ,  A61K9/107 ,  A61K31/65

Abstract: A formulation includes a plurality of polymers including a hydrophobic polymer backbone (for example, formed via radical polymerization), a first plurality of pendant groups attached to the hydrophobic polymer backbone and including at least one cationic group, and a second plurality of pendant groups attached to the hydrophobic polymer backbone and including at least one hydrophilic polymer, a first therapeutic compound, and a second therapeutic compound, wherein the second therapeutic compound is different from the first therapeutic compound and includes a nucleic acid.

公开(公告)号：US20180214563A1

公开(公告)日：2018-08-02

申请号：US15748469

申请日：2016-07-28

Applicant: University of Pittsburgh - Of the Commonwealth System of Higher Education

Inventor： Song Li ,  Yichao Chen ,  Yixian Huang

IPC: A61K47/60 ,  A61K47/69 ,  A61K45/06

CPC classification number: A61K47/60 ,  A61K31/337 ,  A61K31/4188 ,  A61K31/704 ,  A61K45/06 ,  A61K47/6907 ,  A61K2300/00

Abstract: A formulation includes a carrier agent formed by conjugating an immunotherapy agent with a hydrophilic compound. The carrier agent further includes an interactive domain comprising at least one interactive moiety which interacts with a therapeutic agent.

公开(公告)号：US20160128938A9

公开(公告)日：2016-05-12

申请号：US14651840

申请日：2013-12-12

Applicant: UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

Inventor： Xiang Gao ,  Song Li ,  Peter Wipf ,  Michael Wayne Epperly ,  Joel S. Greenberger

IPC: A61K9/107 ,  A61K31/337 ,  A61K31/704 ,  A61K31/45

CPC classification number: A61K9/1075 ,  A61K9/1271 ,  A61K31/337 ,  A61K31/45 ,  A61K31/704

Abstract: A method of creating a formulation for a compound includes determining a compound interactive agent comprising at least one group that interacts with the compound, creating a carrier agent by conjugating at least one compound interactive domain comprising the at least one group that interacts with the compound with at least one hydrophilic domain, and combining the compound and the carrier agent to create the formulation. Creating the carrier agent may further include conjugating the at least one compound interactive domain with at least one hydrophobic domain so that the at least one compound interactive domain is positioned between the at least one hydrophilic domain and the at least one hydrophobic domain.

公开(公告)号：US20250084416A1

公开(公告)日：2025-03-13

申请号：US18728870

申请日：2022-09-19

Applicant: University of Pittsburgh - Of the Commonwealth System of Higher Education

Inventor： Song Li ,  Yuang Chen

IPC: C12N15/113 ,  A61K47/60 ,  A61K47/61 ,  A61K47/64

Abstract: A therapeutic system or combination includes a first therapeutic agent to treat a disease condition and a second therapeutic agent adnrinistrable within a predetermined time of administration of the first therapeutic agent the second therapeutic agent inhibiting the function of Xkr8.

公开(公告)号：US10172795B2

公开(公告)日：2019-01-08

申请号：US14651840

申请日：2013-12-12

Applicant: University of Pittsburgh—Of The Commonwealth System of Higher Education

Inventor： Xiang Gao ,  Song Li ,  Peter Wipf ,  Michael Wayne Epperly ,  Joel S. Greenberger

IPC: A61K31/45 ,  A61K9/107 ,  A61K9/127 ,  A61K31/337 ,  A61K31/704

Abstract: A method of creating a formulation for a compound includes determining a compound interactive agent comprising at least one group that interacts with the compound, creating a carrier agent by conjugating at least one compound interactive domain comprising the at least one group that interacts with the compound with at least one hydrophilic domain, and combining the compound and the carrier agent to create the formulation. Creating the carrier agent may further include conjugating the at least one compound interactive domain with at least one hydrophobic domain so that the at least one compound interactive domain is positioned between the at least one hydrophilic domain and the at least one hydrophobic domain.

公开(公告)号：US12150969B2

公开(公告)日：2024-11-26

申请号：US16088228

申请日：2017-03-24

Applicant: University of Pittsburgh—Of the Commonwealth System of Higher Education

Inventor： Song Li ,  Stephen Howard Thorne

IPC: A61K35/76 ,  A61K9/127 ,  A61K47/10 ,  A61K47/24 ,  A61K47/28 ,  A61K47/34 ,  A61K47/69 ,  A61P35/00

Abstract: A method of modifying a virus for in vivo delivery to a region of interest includes forming an enveloping composition including a lipid conjugate formed by conjugating at least one lipid with at least one hydrophilic compound via a linkage which is cleavable under conditions present in the region of interest and combining the virus with the enveloping composition to encompass the virus within the enveloping structure.