公开(公告)号：US11673853B2

公开(公告)日：2023-06-13

申请号：US17313577

申请日：2021-05-06

申请人： University of Pittsburgh—Of the Commonwealth System of Higher Education ,  The United States as represented by the Department of Veterans Affairs

发明人： Beibei Chen ,  Rama K. Mallampalli ,  Yuan Liu

IPC分类号： C07C217/34 ,  C07C215/08 ,  C07C215/18 ,  C07D205/04 ,  C07D217/04 ,  C07D311/88 ,  A61P29/00

CPC分类号： C07C217/34 ,  A61P29/00 ,  C07C215/08 ,  C07C215/18 ,  C07D205/04 ,  C07D217/04 ,  C07D311/88

摘要： Described herein are compounds that disrupt the interaction between Fbxo48 and phosphorylated-AMPK.

公开(公告)号：US11040935B2

公开(公告)日：2021-06-22

申请号：US16339534

申请日：2017-10-04

申请人： University of Pittsburgh—Of the Commonwealth System of Higher Education ,  The United States as represented by the Department of Veterans Affairs

发明人： Beibei Chen ,  Rama K. Mallampalli ,  Yuan Liu

IPC分类号： C07C217/34 ,  C07D215/08 ,  C07C215/18 ,  C07D205/04 ,  C07D217/04 ,  C07D311/88 ,  A61P29/00 ,  C07C215/08

摘要： Described herein are compounds that disrupt the interaction between Fbxo48 and phosphorylated-AMPK.

公开(公告)号：US20220153685A1

公开(公告)日：2022-05-19

申请号：US17313577

申请日：2021-05-06

申请人： University of Pittsburg-Of the Commonealth System of Higher Education ,  The United States as represented by the Department of Veterans Affairs

发明人： Beibei Chen ,  Rama K. Mallampalli ,  Yuan Liu

IPC分类号： C07C217/34 ,  A61P29/00 ,  C07C215/08 ,  C07C215/18 ,  C07D205/04 ,  C07D217/04 ,  C07D311/88

摘要： Described herein are compounds that disrupt the interaction between Fbxo48 and phosphorylated-AMPK.

公开(公告)号：US11242339B2

公开(公告)日：2022-02-08

申请号：US16624843

申请日：2018-06-25

申请人： University of Pittsburgh—Of the Commonwealth System of Higher Education ,  The United States Government as represented by the Department of Veterans Affairs

发明人： Rama K. Mallampalli ,  Beibei Chen ,  Charleen T. Chu ,  Yuan Liu

IPC分类号： C07D405/12 ,  A61P25/28 ,  A61P25/16 ,  A61K31/517

摘要： A method for treating a neurodegenerative disease or an inflammatory disorder in a subject, comprising administering to the subject in need thereof, a compound, or a pharmaceutically acceptable salt thereof, of formula II: wherein each of R3-R7 is independently H, halogen, optionally-substituted alkyl, amino, alkoxy or hydroxy; R8 is an optionally-substituted heterocycloalkyl; and a is 0 to 3.

公开(公告)号：US20230310424A1

公开(公告)日：2023-10-05

申请号：US18022677

申请日：2021-11-19

申请人： University of Pittsburgh - Of the Commonwealth System of Higher Education

发明人： Beibei Chen ,  Toren Finkel ,  Yuan Liu

IPC分类号： A61K31/498 ,  A61K31/4985

CPC分类号： A61K31/498 ,  A61K31/4985

摘要： This document provides compounds that can increase NAMPT activity, as well as the methods of using such compounds to treat diseases, disorders, and conditions such as traumatic nerve and/or brain injuries, chemotherapeutic-induced or diabetic neuropathies, and neurodegenerative diseases.

公开(公告)号：US20220169632A1

公开(公告)日：2022-06-02

申请号：US17432639

申请日：2020-02-21

申请人： University of Pittsburgh - Of the Commonwealth System of Higher Education

发明人： Beibei Chen ,  Toren Finkel ,  Yuan Liu

IPC分类号： C07D401/14 ,  C07D405/12 ,  C07D209/18 ,  C07D409/12 ,  C07D209/08 ,  C07D401/12 ,  C07D401/04 ,  C07D491/048 ,  C07D471/04 ,  C07D405/14 ,  C07D487/06 ,  A61K31/405 ,  A61K31/4439 ,  A61K31/5377 ,  A61K31/4355 ,  A61K31/444 ,  A61K31/404 ,  A61K31/4709 ,  A61K31/437 ,  A61K31/496 ,  A61K31/55 ,  A61K45/06

摘要： This document provides methods and materials for increasing or maintaining NMNAT2 polypeptide levels within cells. For example, compounds (e.g., organic compounds) having the ability to increase or maintain NMNAT2 polypeptide levels within cells, formulations containing compounds having the ability to increase or maintain NMNAT2 polypeptide levels within cells, methods for making compounds having the ability to increase or maintain NMNAT2 polypeptide levels within cells, methods for making formulations containing compounds having the ability to increase or maintain NMNAT2 polypeptide levels within cells, methods for increasing or maintain NMNAT2 polypeptide levels within cells, and methods for treating mammals (e.g., humans) having a condition responsive to an increase in NMNAT2 polypeptide levels are provided (or for preventing said condition).

公开(公告)号：US20220112218A1

公开(公告)日：2022-04-14

申请号：US17420597

申请日：2020-01-03

申请人： University of Pittsburgh - Of the Commonwealth System of Higher Education

发明人： Beibei Chen ,  Toren Finkel ,  Yuan Liu

IPC分类号： C07D519/00 ,  A61P25/28

摘要： This document provides methods and materials for increasing TFEB polypeptide levels. For example, compounds (e.g., organic compounds) having the ability to increase TFEB polypeptide levels within cells and/or within a nucleus of cells, formulations containing compounds having the ability to increase TFEB polypeptide levels within cells and/or within a nucleus of cells, methods for making compounds having the ability to increase TFEB polypeptide levels within cells and/or within a nucleus of cells, methods for making formulations containing compounds having the ability to increase TFEB polypeptide levels within cells and/or within a nucleus of cells, methods for increasing TFEB polypeptide levels within cells and/or within a nucleus of cells, and methods for treating mammals (e.g., humans) having a condition responsive to an increase in TFEB polypeptide levels are provided.

公开(公告)号：US20200216426A1

公开(公告)日：2020-07-09

申请号：US16624843

申请日：2018-06-25

申请人： University of Pittsburgh - Of the Commonwealth System of Higher Education ,  The United States Government as represented by the Department of Veterans Affairs

发明人： Rama K. Mallampalli ,  Beibei Chen ,  Charleen T. Chu ,  Yuan Liu

IPC分类号： C07D405/12 ,  A61P25/16 ,  A61P25/28

摘要： A method for treating a neurodegenerative disease or an inflammatory disorder in a subject, comprising administering to the subject in need thereof, a compound, or a pharmaceutically acceptable salt thereof, of formula II: wherein each of R3-R7 is independently H, halogen, optionally-substituted alkyl, amino, alkoxy or hydroxy; R8 is an optionally-substituted heterocycloalkyl; and a is 0 to 3.

公开(公告)号：US20240000806A1

公开(公告)日：2024-01-04

申请号：US18022654

申请日：2021-11-19

申请人： University of Pittsburgh - Of the Commonwealth System of Higher Education

发明人： Beibei Chen ,  Toren Finkel ,  Yuan Liu

IPC分类号： A61K31/635

CPC分类号： A61K31/635

摘要： This document provides compounds that can inhibit CB1 activity within a mammal (e.g., a human), as well as the methods of using such compounds for treating diseases, disorders, and conditions such as obesity, fear, metabolic-related disorders, diabetes, dyslipidaemia, and atherosclerosis.

公开(公告)号：US20230041576A1

公开(公告)日：2023-02-09

申请号：US17778492

申请日：2020-11-20

申请人： University of Pittsburgh - Of the Commonwealth System of Higher Education

发明人： Beibei Chen ,  Toren Finkel ,  Yuan Liu

IPC分类号： C07D215/36 ,  C07D311/12 ,  C07D213/71 ,  C07D471/04 ,  C07D215/40 ,  C07D217/24 ,  C07D265/36 ,  C07D487/04 ,  C07D267/14 ,  C07D263/46 ,  C07D277/36 ,  C07D241/42 ,  C07D403/04 ,  C07D401/12 ,  C07D403/12

摘要： This document provides compounds that are inhibitors of NF-κB activity, as well as the methods of using such compounds for treating diseases and conditions such as cancer, inflammatory conditions, or autoimmune diseases.