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公开(公告)号：US10849395B2
公开(公告)日：2020-12-01
申请号：US15958947
申请日：2018-04-20
申请人： University of Washington , The United States as represented by the Department of Veterans Affairs
摘要： Several embodiments are provided of a device which is tunable for providing a walking aid user with passive haptic feedback. The haptic feedback is provided to the user when a predetermined, desired force in the device is reached. The force, often simply an axial force, in the device is inputted by the user, who is looking to support some of his or her body weight, thereby taking some weight off of one or both legs for some purpose. The amount of body weight support the user would input is often expressed in terms of percentage of the user's total body weight, and can therefore be predetermined and the device tuned accordingly.
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2.发明申请公开(公告)号：US20200009105A1
公开(公告)日：2020-01-09
申请号：US16489382
申请日：2018-02-28
发明人： Stokes PEEBLES
IPC分类号： A61K31/343 , A61K31/191 , A61P11/08 , A61P37/06
摘要： The present disclosure relates to methods for treating or preventing rejection of solid organ transplants by administering prostacyclin (PGI2) or a prostacyclin analog.
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公开(公告)号：US20190352355A1
公开(公告)日：2019-11-21
申请号：US16481128
申请日：2018-01-29
摘要： Disclosed herein are compositions and methods for inhibiting collagen production mediated by the Fused in Sarcoma (FUS) ribonucleoprotein. As disclosed herein, the C terminal domain of FUS contains an uncommon nuclear localization sequence (NLS) motif called PY-NLS that binds the nuclear import receptor transportin. Phosphorylation of FUS leads to its association with transportin and nuclear translocation with consequent increased in collagen production. Therefore, disclosed herein is an isolated peptide having a transportin-binding moiety, which inhibits FUS from binding transportin, linked to a membrane translocating motif. These compositions and methods can be used to inhibit FUS-mediated collagen production, and treat fibrotic disease involving FUS-mediated collagen accumulation in kidneys and other organs displaying fibrotic diseases.
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4.发明授权公开(公告)号：US09523080B2
公开(公告)日：2016-12-20
申请号：US14591819
申请日：2015-01-07
申请人： University of Maryland, Baltimore , The United States as Represented by the Department of Veterans Affairs
IPC分类号： C12N5/00 , C12N5/0775 , C12N5/0789 , A61K35/28 , A61K35/12
CPC分类号： C12N5/0662 , A61K35/28 , A61K2035/124 , C12N5/0647 , C12N2500/30 , C12N2500/44 , C12N2500/90 , C12N2501/125 , C12N2501/23
摘要： The present invention relates to methods and compositions concerning isolation of proliferating cells. In particular, the invention regards enrichment of stem cells in a mixture of stem cells and non-stem cells, wherein the non-stem cells may be differentiated cells. The invention exploits the non-adherent property of stem cells, as opposed to the adherent property of differentiating cells, by serially passaging the suspended cells in liquid media.
摘要翻译： 本发明涉及关于增殖细胞分离的方法和组合物。 特别地，本发明涉及干细胞在干细胞和非干细胞混合物中的富集，其中非干细胞可以是分化细胞。 通过将悬浮细胞连续传代在液体培养基中，本发明利用了干细胞的非贴壁性质，与分化细胞的粘附性质相反。
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5.发明授权公开(公告)号：US12036042B2
公开(公告)日：2024-07-16
申请号：US18108808
申请日：2023-02-13
申请人： Case Western Reserve University , The United States as represented by the Department of Veterans Affairs
CPC分类号： A61B5/683 , A61B5/02141 , A61B5/02444 , A61B5/026 , A61B5/6876 , G01L9/0052 , G01L9/06 , A61B2562/12
摘要： A sensor apparatus includes at least one substrate layer of an elastically deformable material, the substrate layer extending longitudinally between spaced apart ends thereof. A conductive layer is attached to and extends longitudinally between the spaced apart ends of the at least one substrate layer. The conductive layer includes an electrically conductive material adapted to form a strain gauge having an electrical resistance that varies based on deformation of the conductive layer in at least one direction.
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6.发明公开公开(公告)号：US20240197250A1
公开(公告)日：2024-06-20
申请号：US18413120
申请日：2024-01-16
申请人： Case Western Reserve University , The United States as represented by the Department of Veterans Affairs
CPC分类号： A61B5/683 , A61B5/02141 , A61B5/02444 , A61B5/026 , A61B5/6876 , G01L9/0052 , G01L9/06 , A61B2562/12
摘要： A sensor apparatus includes at least one substrate layer of an elastically deformable material, the substrate layer extending longitudinally between spaced apart ends thereof. A conductive layer is attached to and extends longitudinally between the spaced apart ends of the at least one substrate layer. The conductive layer includes an electrically conductive material adapted to form a strain gauge having an electrical resistance that varies based on deformation of the conductive layer in at least one direction.
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公开(公告)号：US11771739B2
公开(公告)日：2023-10-03
申请号：US16622469
申请日：2018-06-18
摘要： Disclosed are compositions and methods for treating microbial inflammation including its end-stage sepsis and conditions associated with the microbial inflammation such as thrombocytopenia and hypoglycogenemia. In one aspect, the compositions and methods disclosed herein can also be used to enhance clearance of microbes from infected tissues, organs, or systems in a subject. Also disclosed herein are compositions and methods for reducing levels of stress responsible transcription factors and metabolic transcription factors in a cell in a subject with microbial inflammation.
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公开(公告)号：US20230291143A1
公开(公告)日：2023-09-14
申请号：US18015357
申请日：2021-07-15
申请人： Case Western Reserve University , The United States as represented by the Department of Veterans Affairs
IPC分类号： H01R13/621 , A61N1/375 , H01R24/58
CPC分类号： H01R13/621 , A61N1/375 , H01R24/58 , H01R2201/12
摘要： An inline implantable connector device can provide an increased volume density to medical device systems in a limited volume. The inline implantable connector device can have a claim-shell design with a first half and a second half, each having a conductive path in a same design. The second half is turned and flipped by 180 degrees to mate with the first half so that the conductive paths interconnect to form electrical and mechanical interconnections that are fundamentally transverse to the direction of the incoming or outgoing lead wires. A first screw hole on a top side of the connector device can accept a screw therethrough; and a second screw hole on a bottom side of the connector device can accept another screw therethrough.
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公开(公告)号：US20230236193A1
公开(公告)日：2023-07-27
申请号：US18009956
申请日：2021-06-11
申请人： VANDERBILT UNIVERSITY , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , THE UNITED STATES AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
发明人： Tina IVERSON , Barbara BENSING , Paul SULLAM
IPC分类号： G01N33/574 , G01N33/535
CPC分类号： G01N33/57484 , G01N33/535 , G01N2440/38
摘要： Disclosed are compositions and methods related to the use of sialoglycan as markers for the diagnosis and prognosis of cancers and inflammatory conditions. In one aspect, also disclosed herein are engineered probes and chimeric probes with differential binding ability to sialoglycans.
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公开(公告)号：US11236398B2
公开(公告)日：2022-02-01
申请号：US16489604
申请日：2018-03-01
IPC分类号： C12Q1/68 , C12Q1/6886
摘要： The disclosure provides a method to detect sessile serrated adenomas/polyps (SSA/Ps) and to differentiate SSA/Ps from hyperplastic polyps (HPs). The method uses a molecular signature that is platform-independent and could be used with multiple platforms such as microarray, RNA-seq or real-time quantitative platforms.
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