公开(公告)号：US11300542B2

公开(公告)日：2022-04-12

申请号：US16804787

申请日：2020-02-28

Applicant: University of Rhode Island Board of Trustees

Inventor： Jimmie Oxley ,  James L. Smith ,  Alexander Yevdokimov ,  Gerald Kagan

IPC: H01J49/00 ,  G01N27/622 ,  H01J49/04 ,  H01J49/02

Abstract: The present disclosure describes an improved sample preparation technique and adapter device for the removal of trace materials from swabs and delivery of the trace materials into a mass spectrometer (MS) or an ion mobility spectrometer (IMS). The adapter device and technique aids the delivery of the analyte into the instrument inlet and concurrently serves as an ionization source. The technique includes the steps of positioning or shaping the swab so that a pointed analyte release corner or tip is directed toward the inlet of the MS or IMS, adding a solvent to the swab and charging the swab to create an ionized analyte spray pointed at or positioned within the inlet of the detection instrument.

公开(公告)号：US20200292495A1

公开(公告)日：2020-09-17

申请号：US16804787

申请日：2020-02-28

Applicant: University of Rhode Island Board of Trustees

Inventor： Jimmie Oxley ,  James L. Smith ,  Alexander Yevdokimov ,  Gerald Kagan

IPC: G01N27/62 ,  H01J49/00 ,  H01J49/04

Abstract: The present disclosure describes an improved sample preparation technique and adapter device for the removal of trace materials from swabs and delivery of the trace materials into a mass spectrometer (MS) or an ion mobility spectrometer (IMS). The adapter device and technique aids the delivery of the analyte into the instrument inlet and concurrently serves as an ionization source. The technique includes the steps of positioning or shaping the swab so that a pointed analyte release corner or tip is directed toward the inlet of the MS or IMS, adding a solvent to the swab and charging the swab to create an ionized analyte spray pointed at or positioned within the inlet of the detection instrument.

公开(公告)号：US20220229017A1

公开(公告)日：2022-07-21

申请号：US17715287

申请日：2022-04-07

Applicant: University of Rhode Island Board of Trustees

Inventor： Jimmie Oxley ,  James L. Smith ,  Alexander Yevdokimov

IPC: G01N27/622 ,  H01J49/26 ,  H01J49/00

Abstract: The present disclosure describes an improved sample preparation technique, swab, swab holder and solvent for the removal of trace chemical materials from swabs and delivery of the trace materials into a mass spectrometer (MS) or an ion mobility spectrometer (IMS). The devices and techniques aid the delivery of the analyte into the instrument inlet and concurrently serves as an ionization source. The technique includes the steps of positioning or shaping the swab so that a pointed analyte release area is directed toward the inlet of the MS or IMS, adding a solvent to the swab and charging the swab to create an ionized analyte spray (Taylor Cone spray) into the inlet of the detection instrument. Solvent may include a chemical for depressing the ionization of residual solvent or enhancing the ionization of the desired analyte and this chemical may serve as an internal standard or benchmark.