公开(公告)号：US12162923B2

公开(公告)日：2024-12-10

申请号：US17549367

申请日：2021-12-13

Applicant: University of Utah Research Foundation

Inventor： Mingnan Chen ,  Peng Zhao

IPC: A61K38/39 ,  A61K9/00 ,  A61K9/107 ,  A61K9/51 ,  A61K38/16 ,  A61K39/00 ,  A61K39/39 ,  A61K39/395 ,  A61K47/34 ,  A61P35/00 ,  C07K14/36 ,  C07K14/78 ,  C07K16/28

Abstract: Disclosed herein, are nanoparticles comprising one or more immune-tolerant elastin-like polypeptide tetramers and one or more immune-tolerant elastin-like fusion molecules. Also, disclosed herein are pharmaceutical compositions including the nanoparticles; methods of administering the nanoparticles to patients for the treatment of cancer; and methods of making the nanoparticles.

公开(公告)号：US20220112268A1

公开(公告)日：2022-04-14

申请号：US17549367

申请日：2021-12-13

Applicant: University of Utah Research Foundation

Inventor： Mingnan Chen ,  Peng Zhao

IPC: C07K14/78 ,  A61K38/16 ,  A61K39/395 ,  A61K9/51 ,  A61K39/00 ,  C07K16/28 ,  A61P35/00 ,  A61K39/39 ,  A61K9/107 ,  A61K9/00 ,  A61K47/34 ,  A61K38/39 ,  C07K14/36

Abstract: Disclosed herein, are nanoparticles comprising one or more immune-tolerant elastin-like polypeptide tetramers and one or more immune-tolerant elastin-like fusion molecules. Also, disclosed herein are pharmaceutical compositions including the nanoparticles; methods of administering the nanoparticles to patients for the treatment of cancer; and methods of making the nanoparticles.

公开(公告)号：US20220280615A1

公开(公告)日：2022-09-08

申请号：US17637639

申请日：2020-06-30

Applicant: University of Utah Research Foundation

Inventor： Mingnan Chen ,  Peng Wang ,  Peng Zhao ,  Shuyun Dong

IPC: A61K38/39 ,  A61K47/64 ,  A61K47/42 ,  A61K9/00 ,  A61K47/02 ,  A61P35/00

Abstract: Disclosed herein, are recombinant polypeptides comprising one or more homologous amino acid repeats fused with an IgG binding domain The recombinant polypeptides can be bound to a therapeutic antibody and used a delivery vehicle to increase the retention time and reduce systemic-related side effects of the therapeutic antibodies. Also disclosed herein are pharmaceutical compositions including the recombinant polypeptides bound to a therapeutic antibody; and methods of administering the same to patients

公开(公告)号：US11198722B2

公开(公告)日：2021-12-14

申请号：US16152825

申请日：2018-10-05

Applicant: University of Utah Research Foundation

Inventor： Mingnan Chen ,  Peng Zhao

IPC: C07K14/78 ,  A61K39/00 ,  C07K16/28 ,  A61K39/395 ,  A61K9/00 ,  A61P35/00 ,  A61K9/51 ,  C07K14/36 ,  A61K38/16 ,  A61K38/39 ,  A61K47/34 ,  A61K9/107 ,  A61K39/39

Abstract: Disclosed herein, are nanoparticles comprising one or more immune-tolerant elastin-like polypeptide tetramers and one or more immune-tolerant elastin-like fusion molecules. Also, disclosed herein are pharmaceutical compositions including the nanoparticles; methods of administering the nanoparticles to patients for the treatment of cancer; and methods of making the nanoparticles.

公开(公告)号：US20240285789A1

公开(公告)日：2024-08-29

申请号：US18173680

申请日：2023-02-23

Applicant: University of Utah Research Foundation

Inventor： Mingnan Chen ,  Shuyun Dong ,  Tianxiao Zhang

IPC: A61K47/68 ,  C07K14/34 ,  C07K14/76 ,  C07K16/28

CPC classification number: A61K47/6829 ,  C07K14/34 ,  C07K14/76 ,  C07K16/2818 ,  C07K2317/622 ,  C07K2319/01 ,  C07K2319/30

Abstract: Disclosed are polypeptides comprising a diphtheria toxin and a PD1 targeting moiety. Disclosed are polypeptides comprising, from N- to C-terminus, a truncated diphtheria toxin, and two anti-PD-1 scFvs. Disclosed are nucleic acid constructs comprising a nucleic acid sequence encoding any one of the disclosed polypeptides. Disclosed are nucleic acid constructs comprising a nucleic acid sequence encoding a diphtheria toxin linked to a nucleic acid sequence encoding a PD1 targeting moiety. Disclosed are methods of treating a subject in need thereof comprising administering to the subject a composition comprising one or more of the disclosed polypeptides, vectors, or pharmaceutical compositions.

公开(公告)号：US20180289830A1

公开(公告)日：2018-10-11

申请号：US15577998

申请日：2016-05-27

Applicant: University of Utah Research Foundation

Inventor： Mingnan Chen ,  Hyung Jin Cho ,  Peng Wang ,  Shuyun Dong ,  Peng Zhao

IPC: A61K47/64 ,  C07K14/78 ,  A61K31/35 ,  A61K31/337 ,  C07K14/77 ,  A61P35/00 ,  A61P35/04 ,  A61K39/00

Abstract: Disclosed herein, are recombinant polypeptides comprising one or more homologous amino acid repeats; and, non-immunogenic bioconjugates comprising recombinant polypeptides comprising one or more homologous amino acid repeats and one or more therapeutic agents. Also, disclosed herein are pharmaceutical compositions including the recombinant polypeptides; and methods of administering the recombinant polypeptides to patients for the treatment of cancer or infections.

公开(公告)号：US11957762B2

公开(公告)日：2024-04-16

申请号：US15577998

申请日：2016-05-27

Applicant: University of Utah Research Foundation

Inventor： Mingnan Chen ,  Hyung Jin Cho ,  Peng Wang ,  Shuyun Dong ,  Peng Zhao

IPC: A61K47/64 ,  A61K31/337 ,  A61K31/35 ,  A61K38/00 ,  A61K39/00 ,  A61P35/00 ,  A61P35/04 ,  C07K14/77 ,  C07K14/78

CPC classification number: A61K47/6435 ,  A61K31/337 ,  A61K31/35 ,  A61K39/0005 ,  A61K47/64 ,  A61P35/00 ,  A61P35/04 ,  C07K14/77 ,  C07K14/78 ,  A61K38/00 ,  A61K2039/6031 ,  C07K2319/00

Abstract: Disclosed herein, are recombinant polypeptides comprising one or more homologous amino acid repeats; and, non-immunogenic bioconjugates comprising recombinant polypeptides comprising one or more homologous amino acid repeats and one or more therapeutic agents. Also, disclosed herein are pharmaceutical compositions including the recombinant polypeptides; and methods of administering the recombinant polypeptides to patients for the treatment of cancer or infections.

公开(公告)号：US20200239575A1

公开(公告)日：2020-07-30

申请号：US16652629

申请日：2018-10-05

Applicant: University of Utah Research Foundation

Inventor： Mingnan Chen ,  Peng Zhao ,  Peng Wang

IPC: C07K16/28 ,  C07K14/21 ,  C07K14/415

Abstract: Disclosed herein, are fusion proteins comprising a targeting moiety, a plasma protein binding domain, and a toxin or biological variant thereof. Also described herein, are methods of administering the fusion proteins to patients with an autoimmune disease.

公开(公告)号：US20190106479A1

公开(公告)日：2019-04-11

申请号：US16152825

申请日：2018-10-05

Applicant: University of Utah Research Foundation

Inventor： Mingnan Chen ,  Peng Zhao

IPC: C07K14/78 ,  A61K38/39 ,  C07K16/28 ,  A61K39/395 ,  A61K9/00 ,  A61P35/00 ,  A61K9/51 ,  C07K14/36 ,  A61K38/16 ,  A61K39/00

Abstract: Disclosed herein, are nanoparticles comprising one or more immune-tolerant elastin-like polypeptide tetramers and one or more immune-tolerant elastin-like fusion molecules. Also, disclosed herein are pharmaceutical compositions including the nanoparticles; methods of administering the nanoparticles to patients for the treatment of cancer; and methods of making the nanoparticles.