公开(公告)号：US20220280615A1

公开(公告)日：2022-09-08

申请号：US17637639

申请日：2020-06-30

Applicant: University of Utah Research Foundation

Inventor： Mingnan Chen ,  Peng Wang ,  Peng Zhao ,  Shuyun Dong

IPC: A61K38/39 ,  A61K47/64 ,  A61K47/42 ,  A61K9/00 ,  A61K47/02 ,  A61P35/00

Abstract: Disclosed herein, are recombinant polypeptides comprising one or more homologous amino acid repeats fused with an IgG binding domain The recombinant polypeptides can be bound to a therapeutic antibody and used a delivery vehicle to increase the retention time and reduce systemic-related side effects of the therapeutic antibodies. Also disclosed herein are pharmaceutical compositions including the recombinant polypeptides bound to a therapeutic antibody; and methods of administering the same to patients

公开(公告)号：US11957762B2

公开(公告)日：2024-04-16

申请号：US15577998

申请日：2016-05-27

Applicant: University of Utah Research Foundation

Inventor： Mingnan Chen ,  Hyung Jin Cho ,  Peng Wang ,  Shuyun Dong ,  Peng Zhao

IPC: A61K47/64 ,  A61K31/337 ,  A61K31/35 ,  A61K38/00 ,  A61K39/00 ,  A61P35/00 ,  A61P35/04 ,  C07K14/77 ,  C07K14/78

CPC classification number: A61K47/6435 ,  A61K31/337 ,  A61K31/35 ,  A61K39/0005 ,  A61K47/64 ,  A61P35/00 ,  A61P35/04 ,  C07K14/77 ,  C07K14/78 ,  A61K38/00 ,  A61K2039/6031 ,  C07K2319/00

Abstract: Disclosed herein, are recombinant polypeptides comprising one or more homologous amino acid repeats; and, non-immunogenic bioconjugates comprising recombinant polypeptides comprising one or more homologous amino acid repeats and one or more therapeutic agents. Also, disclosed herein are pharmaceutical compositions including the recombinant polypeptides; and methods of administering the recombinant polypeptides to patients for the treatment of cancer or infections.

公开(公告)号：US20240285789A1

公开(公告)日：2024-08-29

申请号：US18173680

申请日：2023-02-23

Applicant: University of Utah Research Foundation

Inventor： Mingnan Chen ,  Shuyun Dong ,  Tianxiao Zhang

IPC: A61K47/68 ,  C07K14/34 ,  C07K14/76 ,  C07K16/28

CPC classification number: A61K47/6829 ,  C07K14/34 ,  C07K14/76 ,  C07K16/2818 ,  C07K2317/622 ,  C07K2319/01 ,  C07K2319/30

Abstract: Disclosed are polypeptides comprising a diphtheria toxin and a PD1 targeting moiety. Disclosed are polypeptides comprising, from N- to C-terminus, a truncated diphtheria toxin, and two anti-PD-1 scFvs. Disclosed are nucleic acid constructs comprising a nucleic acid sequence encoding any one of the disclosed polypeptides. Disclosed are nucleic acid constructs comprising a nucleic acid sequence encoding a diphtheria toxin linked to a nucleic acid sequence encoding a PD1 targeting moiety. Disclosed are methods of treating a subject in need thereof comprising administering to the subject a composition comprising one or more of the disclosed polypeptides, vectors, or pharmaceutical compositions.

公开(公告)号：US20180289830A1

公开(公告)日：2018-10-11

申请号：US15577998

申请日：2016-05-27

Applicant: University of Utah Research Foundation

Inventor： Mingnan Chen ,  Hyung Jin Cho ,  Peng Wang ,  Shuyun Dong ,  Peng Zhao

IPC: A61K47/64 ,  C07K14/78 ,  A61K31/35 ,  A61K31/337 ,  C07K14/77 ,  A61P35/00 ,  A61P35/04 ,  A61K39/00

Abstract: Disclosed herein, are recombinant polypeptides comprising one or more homologous amino acid repeats; and, non-immunogenic bioconjugates comprising recombinant polypeptides comprising one or more homologous amino acid repeats and one or more therapeutic agents. Also, disclosed herein are pharmaceutical compositions including the recombinant polypeptides; and methods of administering the recombinant polypeptides to patients for the treatment of cancer or infections.