公开(公告)号：US20240277671A1

公开(公告)日：2024-08-22

申请号：US18622489

申请日：2024-03-29

Applicant: University of Virginia Patent Foundation

Inventor： Bankole A. Johnson

IPC: A61K31/4178 ,  A61K31/7048 ,  C12Q1/6883 ,  C12Q1/6888 ,  G16B20/00

CPC classification number: A61K31/4178 ,  A61K31/7048 ,  C12Q1/6883 ,  C12Q1/6888 ,  G16B20/00 ,  C12Q2600/106 ,  C12Q2600/156 ,  C12Q2600/172

Abstract: Compositions and methods are provided that are useful for diagnosing, treating, and monitoring alcohol dependence and disorders, susceptibility to alcohol dependence disorders, as well as drug related dependence and disorders. The methods include treating patients with an antagonist of the serotonin receptor 5-HT3 for such disorders, wherein the patient's serotonin transporter gene SLC6A4 is known to have particular genotypes.

公开(公告)号：US20230014787A1

公开(公告)日：2023-01-19

申请号：US17659641

申请日：2022-04-18

Applicant: University of Virginia Patent Foundation

Inventor： Bankole A. Johnson

IPC: A61K31/4178 ,  G16B20/00 ,  C12Q1/6883 ,  C12Q1/6888 ,  A61K31/7048

Abstract: Compositions and methods are provided that are useful for diagnosing, treating, and monitoring alcohol dependence and disorders, susceptibility to alcohol dependence disorders, as well as drug related dependence and disorders. The methods include treating patients with an antagonist of the serotonin receptor 5-HT3 for such disorders, wherein the patient's serotonin transporter gene SLC6A4 is known to have particular genotypes.

公开(公告)号：US11116753B2

公开(公告)日：2021-09-14

申请号：US17061749

申请日：2020-10-02

Applicant: University of Virginia Patent Foundation

Inventor： Bankole A. Johnson

IPC: C12Q1/68 ,  A61K31/4178 ,  G16B20/00 ,  C12Q1/6883 ,  C12Q1/6888 ,  A61K31/7048

Abstract: Compositions and methods are provided that are useful for diagnosing, treating, and monitoring alcohol dependence and disorders, susceptibility to alcohol dependence disorders, as well as drug related dependence and disorders. The methods include treating patients with an antagonist of the serotonin receptor 5-HT3 for such disorders, wherein the patient's serotonin transporter gene SLC6A4 is known to have particular genotypes.

公开(公告)号：US10603307B2

公开(公告)日：2020-03-31

申请号：US15397076

申请日：2017-01-03

Applicant: University of Virginia Patent Foundation

Inventor： Bankole A. Johnson

IPC: C12Q1/68 ,  A61K31/4178 ,  G16B20/00 ,  C12Q1/6883 ,  C12Q1/6888 ,  A61K31/7048

Abstract: Compositions and methods are provided that are useful for diagnosing, treating, and monitoring alcohol dependence and disorders, susceptibility to alcohol dependence disorders, as well as drug related dependence and disorders. The methods include treating patients with an antagonist of the serotonin receptor 5-HT3 for such disorders, wherein the patient's serotonin transporter gene SLC6A4 is known to have particular genotypes.

公开(公告)号：US11905562B2

公开(公告)日：2024-02-20

申请号：US17301660

申请日：2021-04-09

Applicant: University of Virginia Patent Foundation

Inventor： Bankole A. Johnson

IPC: C12Q1/6883 ,  A61K45/06 ,  G01N33/68 ,  G01N33/94 ,  A61K31/4178

CPC classification number: C12Q1/6883 ,  A61K31/4178 ,  A61K45/06 ,  G01N33/6872 ,  G01N33/942 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/156 ,  C12Q2600/158 ,  G01N2800/307 ,  G01N2800/50

Abstract: The gene responsible for encoding SERT has a functional polymorphism at the 5′-regulatory promoter region, which results in two forms, long (L) and short (S). The LL-genotype is hypothesized to play a key role in the early onset of alcohol use. The present invention discloses the differences in treatment and diagnosis based on the L or short genotypes as well as on a single nucleotide polymorphism of the SERT gene, the 3′ UTR SNP rs1042173. The present invention demonstrates the efficacy of using the drug ondansetron and similar drugs for treatment based on variations in the polymorphisms of the SERT gene as well as methods for diagnosing susceptibility to abuse of alcohol and other addiction-related diseases and disorders.

公开(公告)号：US20210301346A1

公开(公告)日：2021-09-30

申请号：US17301660

申请日：2021-04-09

Applicant: University of Virginia Patent Foundation

Inventor： Bankole A. Johnson

IPC: C12Q1/6883 ,  A61K45/06 ,  G01N33/68 ,  G01N33/94 ,  A61K31/4178

Abstract: The gene responsible for encoding SERT has a functional polymorphism at the 5′-regulatory promoter region, which results in two forms, long (L) and short (S). The LL-genotype is hypothesized to play a key role in the early onset of alcohol use. The present invention discloses the differences in treatment and diagnosis based on the L or short genotypes as well as on a single nucleotide polymorphism of the SERT gene, the 3′ UTR SNP rs1042173. The present invention demonstrates the efficacy of using the drug ondansetron and similar drugs for treatment based on variations in the polymorphisms of the SERT gene as well as methods for diagnosing susceptibility to abuse of alcohol and other addiction-related diseases and disorders.

公开(公告)号：US20210000797A1

公开(公告)日：2021-01-07

申请号：US16931813

申请日：2020-07-17

Applicant: University of Virginia Patent Foundation

Inventor： Bankole A. Johnson

IPC: A61K31/4178 ,  C12Q1/6883

Abstract: The present invention provides compositions and methods useful for diagnosing, treating, and monitoring alcohol dependence and disorders and susceptibility to alcohol dependence disorders, as well as drug related dependence and disorders.

公开(公告)号：US20180251840A1

公开(公告)日：2018-09-06

申请号：US15783676

申请日：2017-10-13

Applicant: University of Virginia Patent Foundation

Inventor： Bankole A. Johnson

IPC: C12Q1/6883 ,  A61K31/4178 ,  G01N33/94

CPC classification number: C12Q1/6883 ,  A61K31/4178 ,  A61K45/06 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/156 ,  C12Q2600/158 ,  G01N33/6872 ,  G01N33/942 ,  G01N2800/307 ,  G01N2800/50

Abstract: The gene responsible for encoding SERT has a functional polymorphism at the 5′-regulatory promoter region, which results in two forms, long (L) and short (S). The LL-genotype is hypothesized to play a key role in the early onset of alcohol use. The present invention discloses the differences in treatment and diagnosis based on the L or short genotypes as well as on a single nucleotide polymorphism of the SERT gene, the 3′ UTR SNP rs1042173. The present invention demonstrates the efficacy of using the drug ondansetron and similar drugs for treatment based on variations in the polymorphisms of the SERT gene as well as methods for diagnosing susceptibility to abuse of alcohol and other addiction-related diseases and disorders.

公开(公告)号：US20170239222A1

公开(公告)日：2017-08-24

申请号：US15397076

申请日：2017-01-03

Applicant: University of Virginia Patent Foundation

Inventor： Bankole A. Johnson

IPC: A61K31/4178 ,  C12Q1/68 ,  G06F19/18 ,  A61K31/7048

CPC classification number: A61K31/4178 ,  A61K31/7048 ,  C12Q1/6883 ,  C12Q1/6888 ,  C12Q2600/106 ,  C12Q2600/172 ,  G16B20/00

Abstract: Compositions and methods are provided that are useful for diagnosing, treating, and monitoring alcohol dependence and disorders, susceptibility to alcohol dependence disorders, as well as drug related dependence and disorders. The methods include treating patients with an antagonist of the serotonin receptor 5-HT3 for such disorders, wherein the patient's serotonin transporter gene SLC6A4 is known to have particular genotypes.

公开(公告)号：US12274692B2

公开(公告)日：2025-04-15

申请号：US18622489

申请日：2024-03-29

Applicant: University of Virginia Patent Foundation

Inventor： Bankole A. Johnson

IPC: C12Q1/68 ,  A61K31/4178 ,  A61K31/7048 ,  C12Q1/6883 ,  C12Q1/6888 ,  G16B20/00

Abstract: Compositions and methods are provided that are useful for diagnosing, treating, and monitoring alcohol dependence and disorders, susceptibility to alcohol dependence disorders, as well as drug related dependence and disorders. The methods include treating patients with an antagonist of the serotonin receptor 5-HT3 for such disorders, wherein the patient's serotonin transporter gene SLC6A4 is known to have particular genotypes.