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公开(公告)号：US20250160695A1
公开(公告)日：2025-05-22
申请号：US19028998
申请日：2025-01-17
Applicant: UNIVERSITY OF VIRGINIA PATENT FOUNDATION
Inventor： Boris P. KOVATCHEV , Marc D. BRETON , Stephen D. PATEK
Abstract: An aspect of an embodiment or partial embodiment of the present invention (or combinations of various embodiments in whole or in part of the present invention) comprises, but not limited thereto, a method and system (and related computer program product) for continually assessing the risk of hypoglycemia for a patient and then determining what action to take based on that risk assessment. A further embodiment results in two outputs: (1) an attenuation factor to be applied to the insulin rate command sent to the pump (either via conventional therapy or via open or closed loop control) and/or (2) a red/yellow/green light hypoglycemia alarm providing to the patient an indication of the risk of hypoglycemia. The two outputs of the CPHS can be used in combination or individually.
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公开(公告)号：US20250090052A1
公开(公告)日：2025-03-20
申请号：US18947435
申请日：2024-11-14
Applicant: UNIVERSITY OF VIRGINIA PATENT FOUNDATION
Inventor： Boris P. KOVATCHEV , Marc D. BRETON , Stephen D. PATEK
Abstract: An aspect of an embodiment or partial embodiment of the present invention (or combinations of various embodiments in whole or in part of the present invention) comprises, but not limited thereto, a method and system (and related computer program product) for continually assessing the risk of hypoglycemia for a patient and then determining what action to take based on that risk assessment. A further embodiment results in two outputs: (1) an attenuation factor to be applied to the insulin rate command sent to the pump (either via conventional therapy or via open or closed loop control) and/or (2) a red/yellow/green light hypoglycemia alarm providing to the patient an indication of the risk of hypoglycemia. The two outputs of the CPHS can be used in combination or individually.
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3.发明公开公开(公告)号：US20230368885A1
公开(公告)日：2023-11-16
申请号：US18333955
申请日：2023-06-13
Applicant: UNIVERSITY OF VIRGINIA PATENT FOUNDATION
Inventor： Boris P. KOVATCHEV , Stephen D. PATEK , Marc D. BRETON
CPC classification number: G16H20/17 , G16H50/50 , G16H50/20 , A61B5/7275 , A61B5/14532 , G16H20/30
Abstract: A structure, method, and computer program product for a diabetes control system provides, but is not limited thereto, the following: open-loop or closed-loop control of diabetes that adapts to individual physiologic characteristics and to the behavioral profile of each person. An exemplary aspect to this adaptation is biosystem (patient or subject) observation and modular control. Consequently, established is the fundamental architecture and the principal components for a modular system, which may include algorithmic observers of patients' behavior and metabolic state, as well as interacting control modules responsible for basal rate, insulin boluses, and hypoglycemia prevention.
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公开(公告)号：US20190099555A1
公开(公告)日：2019-04-04
申请号：US16205398
申请日：2018-11-30
Applicant: UNIVERSITY OF VIRGINIA PATENT FOUNDATION
Inventor： Stephen D. PATEK , Marc D. BRETON
Abstract: The invention relates to a methods and systems for determining an insulin dosing recommendation. The invention employs Linear Quadratic methodology to determine the insulin dosing recommendation based on a patient's present physiological state, which is estimated by an adaptive filter methodology employing a dynamic model, which utilizes real-time measurements of blood glucose concentration.
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5.发明申请公开(公告)号：US20250054597A1
公开(公告)日：2025-02-13
申请号：US18931879
申请日：2024-10-30
Applicant: UNIVERSITY OF VIRGINIA PATENT FOUNDATION
Inventor： Boris P. KOVATCHEV , Stephen D. PATEK , Marc D. BRETON
Abstract: A structure, method, and computer program product for a diabetes control system provides, but is not limited thereto, the following: open-loop or closed-loop control of diabetes that adapts to individual physiologic characteristics and to the behavioral profile of each person. An exemplary aspect to this adaptation is biosystem (patient or subject) observation and modular control. Consequently, established is the fundamental architecture and the principal components for a modular system, which may include algorithmic observers of patients' behavior and metabolic state, as well as interacting control modules responsible for basal rate, insulin boluses, and hypoglycemia prevention.
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Patent Agency Ranking
6.发明公开公开(公告)号：US20240245849A1
公开(公告)日：2024-07-25
申请号：US18599531
申请日：2024-03-08
Applicant: UNIVERSITY OF VIRGINIA PATENT FOUNDATION
Inventor： Marc D. BRETON , Stephen D. PATEK , Boris P. KOVATCHEV
IPC: A61M5/142 , A61B5/00 , A61B5/145 , A61M5/168 , A61M5/172 , G16H10/65 , G16H20/17 , G16H40/60 , G16H40/63 , G16H50/20
CPC classification number: A61M5/142 , A61B5/14532 , A61B5/4839 , A61B5/486 , A61B5/4866 , A61B5/7275 , A61B5/746 , A61M5/168 , A61M5/172 , A61M5/1723 , G16H10/65 , G16H20/17 , G16H40/60 , G16H40/63 , G16H50/20 , A61M2005/14208 , A61M2205/18 , A61M2205/3576 , A61M2205/502 , A61M2205/507
Abstract: An insulin monitoring system includes one or more processors, one or more computer-readable storage devices, and program instructions stored on at least one of the one or more storage devices for execution by at least one of the one or more processors. The program instructions include: first program instructions to track, in real time, the amount of insulin active in a patient; second program instructions to calculate the amount of insulin need of the patient by tracking the patient's metabolic states; third program instructions to compare the insulin active in the patient with the insulin need of the patient; and fourth program instructions to determine an insulin fault level based on the comparison.
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公开(公告)号：US20230352185A1
公开(公告)日：2023-11-02
申请号：US18041659
申请日：2021-08-13
Applicant: University of Virginia Patent Foundation
Inventor： Boris P. KOVATCHEV , Marc D. BRETON , Ke WANG , Patricio COLMEGNA
CPC classification number: G16H50/50 , G16H20/17 , G16H20/60 , A61B5/14532
Abstract: A method, system, and computer-readable medium are provided for modeling a time-varying representation of the glucose homeostasis of a patient with Type 1 diabetes (T1D) according to a computational model therefor. The model implements a reconstruction of data supporting a glucose time series for the patient, and based on the reconstruction, further implements model personalization and a variability control (VC) signal accounting for insulin sensitivity so as to enable the patient to learn an effect of adjustment to one or more portions of the data. Such knowledge is acquired upon a replay of the reconstruction implementing the adjustment.
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公开(公告)号：US20230293062A1
公开(公告)日：2023-09-21
申请号：US18325564
申请日：2023-05-30
Applicant: UNIVERSITY OF VIRGINIA PATENT FOUNDATION
Inventor： Boris P. KOVATCHEV , Marc D. BRETON , Stephen D. PATEK
CPC classification number: A61B5/14532 , G16H50/50 , A61B5/746 , A61B5/4839 , A61B5/7275 , G16H20/17 , A61B5/0004 , A61M5/1723 , G16H40/63 , A61B5/0002 , G16H40/67
Abstract: An aspect of an embodiment or partial embodiment of the present invention (or combinations of various embodiments in whole or in part of the present invention) comprises, but not limited thereto, a method and system (and related computer program product) for continually assessing the risk of hypoglycemia for a patient and then determining what action to take based on that risk assessment. A further embodiment results in two outputs: (1) an attenuation factor to be applied to the insulin rate command sent to the pump (either via conventional therapy or via open or closed loop control) and/or (2) a red/yellow/green light hypoglycemia alarm providing to the patient an indication of the risk of hypoglycemia. The two outputs of the CPHS can be used in combination or individually.
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公开(公告)号：US20210313036A1
公开(公告)日：2021-10-07
申请号：US17339153
申请日：2021-06-04
Applicant: UNIVERSITY OF VIRGINIA PATENT FOUNDATION
Inventor： Marc D. BRETON , Stephen D. PATEK , Boris P. KOVATCHEV , Colleen H. KARVETSKY
Abstract: An insulin delivery supervisor (IDS) with a safety analysis and supervision function that can reside between the insulin request and the insulin delivery and can intercept any excessive insulin requests before the insulin was delivered. The IDS can be implemented in any system based on insulin pump or pen and will work with either SMBG or CGM modes of blood glucose monitoring.
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公开(公告)号：US20210282677A1
公开(公告)日：2021-09-16
申请号：US17333161
申请日：2021-05-28
Applicant: UNIVERSITY OF VIRGINIA PATENT FOUNDATION
Inventor： Boris P. Kovatchev , Marc D. BRETON , Stephen D. PATEK
Abstract: An aspect of an embodiment or partial embodiment of the present invention (or combinations of various embodiments in whole or in part of the present invention) comprises, but not limited thereto, a method and system (and related computer program product) for continually assessing the risk of hypoglycemia for a patient and then determining what action to take based on that risk assessment. A further embodiment results in two outputs: (1) an attenuation factor to be applied to the insulin rate command sent to the pump (either via conventional therapy or via open or closed loop control) and/or (2) a red/yellow/green light hypoglycemia alarm providing to the patient an indication of the risk of hypoglycemia. The two outputs of the CPHS can be used in combination or individually.
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