公开(公告)号：US20220160838A1

公开(公告)日：2022-05-26

申请号：US17438760

申请日：2020-03-13

申请人： University of Virginia Patent Foundation

发明人： Gordon W. Laurie ,  Kenneth Brayman ,  Preeti Chhabra ,  Mingyang Ma ,  Karina Teixeira ,  Thomas R. Gadek

IPC分类号： A61K38/26 ,  A61K35/39

摘要： Compositions and methods for regenerating pancreatic islet viability and/or cell proliferation in vitro, ex vivo, and/or in vivo; and/or for regenerating glucose-stimulated insulin secretion; and/or for regenerating viability and/or cell proliferation of a transplanted pancreatic islets; and/or for preventing and/or inhibiting rejection of a transplanted islets; and/or for pancreatic islet transplantation; and/or for treating a symptom of a condition, disorder, or disease associated with abnormal insulin responsiveness to glucose are provided. In some embodiments, the compositions include a peptide and/or a pharmaceutically acceptable salt thereof, and/or a biologically active fragment, analog, or derivative thereof, wherein the peptide, the pharmaceutically acceptable salt thereof, and/or the biologically active fragment, analog, or derivative thereof has an amino acid sequence of any of SEQ ID NOs: 1-60, or any combination thereof.