公开(公告)号：US10426340B2

公开(公告)日：2019-10-01

申请号：US15794407

申请日：2017-10-26

Applicant: University of Virginia Patent Foundation

Inventor： Paul Andrew Yates

IPC: G02C5/14 ,  G02C5/20 ,  A61B3/15 ,  A61B3/12 ,  A61B3/125 ,  A61B3/00 ,  A61B3/135 ,  A61B3/14 ,  G06K9/00 ,  H04N5/225

Abstract: System and method directed towards providing full and even illumination of a patient's retina through lighting integrated into a handheld fundus lens. By integrating the lighting, the method and system reduces and even eliminate many lens artifacts and reflections. By increasing the accuracy, quality, and field of view 10 afforded during clinical examination of the retina, the method and system will allow practitioners to make more accurate diagnoses and will increase safety during retinal surgical procedures.

公开(公告)号：US20230158049A1

公开(公告)日：2023-05-25

申请号：US17917407

申请日：2021-04-06

Applicant: Elias Reichel ,  University of Virginia Patent Foundation

Inventor： Paul Andrew Yates ,  Elias Reichel ,  Ashton Leone

IPC: A61K31/65 ,  A61P31/14 ,  A61K33/30

CPC classification number: A61K31/65 ,  A61P31/14 ,  A61K33/30

Abstract: Disclosed are compositions and methods that can be used for the prevention, mitigation, and/or prophylactic treatment of a viral infection, such but not limited to a coronavirus infection, such as but not limited to a COVID-19 infection. In some embodiments, a chemically modified tetracycline (CMT) derivative for the prevention, mitigation and/or prophylactic treatment of a viral infection is provided. In some embodiments, the CMT derivative lacks anti-microbial activity; comprises a phenol ring; and/or comprises a chemical structure sufficient to chelate and/or bind a divalent cation. In some embodiments, the divalent cation comprises Zn2+. In some embodiments, the viral infection is a coronavirus infection. In some embodiments, the viral infection is a COVID-19 infection.

公开(公告)号：US10426330B2

公开(公告)日：2019-10-01

申请号：US15869715

申请日：2018-01-12

Applicant: University of Virginia Patent Foundation

Inventor： Paul Andrew Yates

IPC: G02C5/14 ,  G02C5/20 ,  A61B3/00 ,  A61B3/12 ,  A61B3/125 ,  A61B3/15 ,  A61B3/14 ,  G06K9/00 ,  H04N5/225

Abstract: System and method directed towards providing full and even illumination of a patient's retina through lighting integrated into a handheld fundus lens. By integrating the lighting, the method and system reduces and even eliminate many lens artifacts and reflections. By increasing the accuracy, quality, and field of view afforded during clinical examination of the retina, the method and system will allow practitioners to make more accurate diagnoses and will increase safety during retinal surgical procedures.

公开(公告)号：US20180242846A1

公开(公告)日：2018-08-30

申请号：US15962183

申请日：2018-04-25

Applicant: University of Virginia Patent Foundation

Inventor： Paul Andrew Yates ,  Kenneth Tran

IPC: A61B3/15 ,  A61B3/12 ,  A61B3/14

CPC classification number: A61B3/156 ,  A61B3/12 ,  A61B3/1208 ,  A61B3/14 ,  G06K9/00604

Abstract: System and Method pertaining to the modification and integration of an existing consumer digital camera, for example, with an optical imaging module to enable point and shoot fundus photography of the eye. The auto-focus macro capability of existing consumer cameras is adapted to photograph the retina over an extended diopter range, eliminating the need for manual diopter focus adjustment. The thru-the-lens (TTL) auto-exposure flash capability of existing consumer cameras is adapted to photograph the retina with automatic flash exposure eliminating the need for manual flash adjustment. The consumer camera imaging sensor and flash are modified to allow the camera sensor to perform both non-mydriatic focusing of the retina using infrared illumination and standard color flash photography of the retina without the need for additional imaging sensors or mechanical filters. These modifications and integration of existing consumer cameras for fundus photography of the eye significantly improve ease of manufacture and usability.

公开(公告)号：US20180055351A1

公开(公告)日：2018-03-01

申请号：US15794456

申请日：2017-10-26

Applicant: University of Virginia Patent Foundation

Inventor： Paul Andrew Yates

IPC: A61B3/00 ,  H04N5/225 ,  G06K9/00 ,  A61B3/15 ,  A61B3/12 ,  A61B3/125 ,  A61B3/14

CPC classification number: A61B3/0008 ,  A61B3/0025 ,  A61B3/12 ,  A61B3/1208 ,  A61B3/125 ,  A61B3/135 ,  A61B3/14 ,  A61B3/156 ,  G06K9/00604 ,  H04N5/2251 ,  H04N5/2256

Abstract: System and method directed towards providing full and even illumination of a patient's retina through lighting integrated into a handheld fundus lens. By integrating the lighting, the method and system reduces and even eliminate many lens artifacts and reflections. By increasing the accuracy, quality, and field of view 10 afforded during clinical examination of the retina, the method and system will allow practitioners to make more accurate diagnoses and will increase safety during retinal surgical procedures.

公开(公告)号：US11813024B2

公开(公告)日：2023-11-14

申请号：US17302123

申请日：2021-04-23

Applicant: University of Virginia Patent Foundation

Inventor： Paul Andrew Yates ,  Kenneth Tran

IPC: A61B3/12 ,  A61B3/15 ,  A61B3/14 ,  G06V40/19

CPC classification number: A61B3/156 ,  A61B3/12 ,  A61B3/1208 ,  A61B3/14 ,  G06V40/19

Abstract: System and Method pertaining to the modification and integration of an existing consumer digital camera, for example, with an optical imaging module to enable point and shoot fundus photography of the eye. The auto-focus macro capability of existing consumer cameras is adapted to photograph the retina over an extended diopter range, eliminating the need for manual diopter focus adjustment. The thru-the-lens (TTL) auto-exposure flash capability of existing consumer cameras is adapted to photograph the retina with automatic flash exposure eliminating the need for manual flash adjustment. The consumer camera imaging sensor and flash are modified to allow the camera sensor to perform both non-mydriatic focusing of the retina using infrared illumination and standard color flash photography of the retina without the need for additional imaging sensors or mechanical filters. These modifications and integration of existing consumer cameras for fundus photography of the eye significantly improve ease of manufacture and usability.

公开(公告)号：US20210275009A1

公开(公告)日：2021-09-09

申请号：US17315994

申请日：2021-05-10

Applicant: University of Virginia Patent Foundation

Inventor： Paul Andrew Yates

IPC: A61B3/00 ,  A61B3/12 ,  A61B3/125 ,  A61B3/15 ,  A61B3/14 ,  G06K9/00 ,  H04N5/225

Abstract: System and method directed towards providing full and even illumination of a patient's retina through lighting integrated into a handheld fundus lens. By integrating the lighting, the method and system reduces and even eliminate many lens artifacts and reflections. By increasing the accuracy, quality, and field of view afforded during clinical examination of the retina, the method and system will allow practitioners to make more accurate diagnoses and will increase safety during retinal surgical procedures.

公开(公告)号：US09962071B2

公开(公告)日：2018-05-08

申请号：US14880621

申请日：2015-10-12

Applicant: University of Virginia Patent Foundation

Inventor： Paul Andrew Yates

IPC: G02C5/14 ,  G02C5/20 ,  A61B3/00 ,  A61B3/12 ,  A61B3/125 ,  A61B3/15 ,  A61B3/14 ,  G06K9/00 ,  H04N5/225

CPC classification number: A61B3/0008 ,  A61B3/12 ,  A61B3/1208 ,  A61B3/125 ,  A61B3/14 ,  A61B3/156 ,  G06K9/00604 ,  H04N5/2251 ,  H04N5/2256

Abstract: System and method directed towards providing full and even illumination of a patient's retina through lighting integrated into a handheld fundus lens. By integrating the lighting, the method and system reduces and even eliminate many lens artifacts and reflections. By increasing the accuracy, quality, and field of view afforded during clinical examination of the retina, the method and system will allow practitioners to make more accurate diagnoses and will increase safety during retinal surgical procedures.

公开(公告)号：US20160287072A1

公开(公告)日：2016-10-06

申请号：US15090054

申请日：2016-04-04

Applicant: University of Virginia Patent Foundation

Inventor： Paul Andrew Yates ,  Kenneth Tran

IPC: A61B3/15 ,  A61B3/00 ,  H04N5/232 ,  A61B3/12

CPC classification number: A61B3/152 ,  A61B3/0008 ,  A61B3/0033 ,  A61B3/0075 ,  A61B3/0091 ,  A61B3/12 ,  A61B3/1208 ,  A61B3/14 ,  H04N5/23212

Abstract: Apparatus and techniques can include using one or more of a portable or fixed optical system to obtain images of a desired anatomical target, such as the fundus region of a human eye. The optical system can include one or more of a laser-based focusing target, a laser-based fixation target, or a removable or adjustable alignment assembly. Such an alignment assembly can provide or allow user alignment based on using anatomical landmarks other than the fundus being imaged. One or more of the apparatus or techniques can be implemented in an optical assembly included as a portion hand-held fundus camera, such as including or using a consumer or commercial digital camera to capture an image.

公开(公告)号：US20160037035A1

公开(公告)日：2016-02-04

申请号：US14880621

申请日：2015-10-12

Applicant: University of Virginia Patent Foundation

Inventor： Paul Andrew Yates

IPC: H04N5/225 ,  G06K9/00

CPC classification number: A61B3/0008 ,  A61B3/12 ,  A61B3/1208 ,  A61B3/125 ,  A61B3/14 ,  A61B3/156 ,  G06K9/00604 ,  H04N5/2251 ,  H04N5/2256

Abstract: System and method directed towards providing full and even illumination of a patient's retina through lighting integrated into a handheld fundus lens. By integrating the lighting, the method and system reduces and even eliminate many lens artifacts and reflections. By increasing the accuracy, quality, and field of view afforded during clinical examination of the retina, the method and system will allow practitioners to make more accurate diagnoses and will increase safety during retinal surgical procedures.

Abstract translation: 系统和方法旨在通过集成到手持眼底透镜中的照明来提供对患者视网膜的全面和均匀照明。 通过整合照明，方法和系统减少甚至消除许多镜头伪影和反射。 通过增加在视网膜临床检查期间提供的准确性，质量和视野，该方法和系统将允许从业者进行更准确的诊断并且将增加视网膜外科手术中的安全性。