公开(公告)号：US20200002398A1

公开(公告)日：2020-01-02

申请号：US16572038

申请日：2019-09-16

Applicant: UNIVERSITY OF WASHINGTON ,  THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY

Inventor： Daniel Adriano SILVA MANZANO ,  Shawn YU ,  Umut ULGE ,  David BAKER ,  Kenan Christopher GARCIA ,  Jamie SPANGLER ,  Carl WALKEY ,  Alfredo QUIJANO RUBIO

IPC: C07K14/55 ,  C07K14/54

Abstract: De novo designed polypeptides that bind to IL-2 receptor βγcheterodimer (IL-2Rβγc), IL-4 receptor αγcheterodimer (IL-4Rαγc), or IL-13 receptor α subunit (IL-13Rα) are disclosed, as are methods for using and designing the polypeptides.

公开(公告)号：US20220235110A1

公开(公告)日：2022-07-28

申请号：US17698553

申请日：2022-03-18

Applicant: UNIVERSITY OF WASHINGTON ,  THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY

Inventor： Daniel Adriano Silva Manzano ,  Shawn Yu ,  Umut Ulge ,  David Baker ,  Kenan Christopher Garcia ,  Jamie Spangler ,  Carl WALKEY

IPC: C07K14/55 ,  C07K14/54 ,  A61K47/62 ,  A61K47/60

Abstract: De novo designed polypeptides that bind to IL-2 receptor βc heterodimer (IL-2Rβc), IL-4 receptor αc heterodimer (IL-4Rαc), or IL-13 receptor α subunit (IL-13Rα) are disclosed, as are methods for using and designing the polypeptides.

公开(公告)号：US20200317744A1

公开(公告)日：2020-10-08

申请号：US16909185

申请日：2020-06-23

Applicant: UNIVERSITY OF WASHINGTON ,  THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY

Inventor： Daniel Adriano Silva Manzano ,  Shawn Yu ,  Umut Ulge ,  David Baker ,  Kenan Christopher Garcia ,  Jamie Spangler ,  Carl WALKEY

IPC: C07K14/55 ,  C07K14/54

Abstract: De novo designed polypeptides that bind to IL-2 receptor βγc heterodimer (IL-2Rβγc), IL-4 receptor αγc heterodimer (IL-4Rαγc), or IL-13 receptor α subunit (IL-13Rα) are disclosed, as are methods for using and designing the polypeptides.

公开(公告)号：US20220144895A1

公开(公告)日：2022-05-12

申请号：US17602119

申请日：2020-04-20

Applicant: University of Washington

Inventor： Scott BOYKEN ,  David BAKER ,  Zibo CHEN ,  Alfredo Quijano RUBIO ,  Neil P. KING ,  Jason C. KLIMA ,  Carl WALKEY

IPC: C07K7/08

Abstract: Disclosed herein are polypeptides or polypeptide oligomers, including a buried hydrogen bond network that includes at least (1, 2, 3, 4, 5, 6, 7, 8, or 9) pH sensitive amino acids located (i) at an intra-chain interface between different: structural elements in one polypeptide, or (it) at an inter-chain interface between structural elements present in different chains of a polypeptide oligomer, wherein the polypeptide or polypeptide oligomer is stable above a given pH, and wherein the polypeptide or polypeptide oligomer undergoes a conformational transition when subjected to a pH at or below the given pH.