公开(公告)号：US20150250899A1

公开(公告)日：2015-09-10

申请号：US14721320

申请日：2015-05-26

Applicant: University of Wyoming

Inventor： Maciej Radosz ,  Youqing Shen ,  Edward Alva VanKirk ,  William James Murdoch

IPC: A61K47/48 ,  C08F267/06 ,  A61K33/24

CPC classification number: C08F267/06 ,  A61K33/24 ,  A61K47/59 ,  A61K47/593 ,  A61K47/60 ,  A61K47/6903 ,  A61K47/6929 ,  A61K47/6935 ,  A61K49/128 ,  A61K49/1803 ,  B82Y5/00

Abstract: A nano-sized hydrogel is made of a water-soluble chain containing carboxylic acid moieties and polyethylene side chains. Such a nanogel is applicable as a cancer-drug delivery agent or an imagining agent, where either a cancer drug, such as cisplatin, or an imaging agent, such as Gd3+. The complexation of the cancer drug or the imaging agent with the carboxyl moieties leads to the hydrogel formation.

Abstract translation: 纳米尺寸的水凝胶由含有羧酸部分和聚乙烯侧链的水溶性链制成。 这样的纳米凝胶可用作癌症药物递送剂或想象剂，其中癌症药物如顺铂或成像剂如Gd 3+。 癌症药物或成像剂与羧基部分的复合导致水凝胶形成。