公开(公告)号：US09872859B2

公开(公告)日：2018-01-23

申请号：US15437878

申请日：2017-02-21

申请人： Upal Roy ,  Hong Ding ,  Madhavan Nair

发明人： Upal Roy ,  Hong Ding ,  Madhavan Nair

IPC分类号： A61K31/536 ,  A61K47/48

CPC分类号： A61K31/536 ,  A61K47/60 ,  A61K47/68 ,  A61K47/6849 ,  A61K47/6907 ,  C07K16/30

摘要： The present invention provides novel, long-acting nanoformulated drugs and targeted drug delivery methods, and uses thereof. In one embodiment, the nanoformulated drug is a retroviral drug. In one embodiment, the nanoformulated composition comprises a nanocarrier with one or more incorporated drugs. In an exemplary embodiment, the drug is efavirenz (EFV). In a further embodiment, the nanocarrier is associated with an agent for targeting microfold cells (M-cells). In a specific embodiment, the targeting agent binds to an M-cell marker known as glycoprotein 2 (GP2). Via this mechanism, the nanodrug is targeted toward GALT.

公开(公告)号：US09616022B1

公开(公告)日：2017-04-11

申请号：US15204652

申请日：2016-07-07

申请人： Upal Roy ,  Vadym Drozd ,  Madhavan Nair ,  Surendra K. Saxena ,  Andriy Durygin

发明人： Upal Roy ,  Vadym Drozd ,  Madhavan Nair ,  Surendra K. Saxena ,  Andriy Durygin

IPC分类号： A61K9/16 ,  A61K31/536

CPC分类号： A61K9/5115 ,  A61K9/0085 ,  A61K31/536 ,  Y10S514/934 ,  Y10S977/773 ,  Y10S977/906

摘要： The subject invention provides materials and methods for treating diseases affecting the central nervous system (CNS) and/or other viral reservoir organs utilizing nanoscopic diamond particles, i.e., nanodiamonds (ND), loaded with therapeutic agents of interests. In one aspect, the subject invention provides a composition for treating a subject's brain and/or other organs acting as viral reservoirs, the composition comprising a plurality of ND particles measuring less than 10 nm in size, wherein the ND particles are loaded with at least one therapeutic agent of interest. In another aspect, the subject invention provides methods of treating disorders affecting the CNS such as, for example, the brain and other viral reservoir organs such as, for example, lymph nodes and gut-associated lymphoid tissues (GALT), utilizing the drug delivery system comprising a plurality of ND particles as provided herein.