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公开(公告)号：US09783545B2
公开(公告)日：2017-10-10
申请号：US15141949
申请日：2016-04-29
Applicant: Usher III Initiative, Inc.
Inventor： Roland Werner Bürli , William Rameshchandra Krishna Esmieu , Christopher James Lock , Karine Fabienne Malagu , Andrew Pate Owens , William E Harte
IPC: C07D487/04 , A61K31/5025 , C07D519/00
CPC classification number: C07D487/04 , A61K31/5025 , C07D519/00
Abstract: Compounds, compositions and methods for the treatment of retinal degenerative diseases, such as retinitis pigmentosa, Leber's congenital Amaurosis, Syndromic retinal degenerations, age-related macular degeneration and Usher Syndrome, and hearing loss associated with Usher Syndrome are described herein.
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2.发明授权Pyrazolopyridazines and methods for treating retinal-degenerative diseases and hearing loss associated with Usher Syndrome 有权吡唑并嘧啶类和治疗视网膜退行性疾病的方法以及与Usher综合征相关的听力损失公开(公告)号：US09079909B2
公开(公告)日：2015-07-14
申请号：US13791205
申请日：2013-03-08
Applicant: Usher III Initiative
Inventor： Roland Werner Bürli , William Rameshchandra Krishna Esmieu , Christopher James Lock , Karine Fabienne Malagu , Andrew Pate Owens , William E Harte
IPC: C07D487/04 , A61K31/40 , C07C243/28 , C07D495/04 , C07C251/86 , C07D519/00 , G01N33/50 , G01N33/68
CPC classification number: A61K31/5025 , A61K31/165 , A61K31/167 , A61K31/40 , C07C243/28 , C07C251/86 , C07C2602/08 , C07D487/04 , C07D495/04 , C07D519/00 , G01N33/502 , G01N33/6848 , G01N33/6893 , G01N2333/4703 , G01N2400/40 , G01N2500/04 , G01N2500/10
Abstract: Compounds, compositions and methods for the treatment of retinal degenerative diseases, such as retinitis pigmentosa, Leber's congenital Amaurosis, Syndromic retinal degenerations, age-related macular degeneration and Usher Syndrome, and hearing loss associated with Usher Syndrome are described herein.
Abstract translation: 本文描述了用于治疗视网膜退行性疾病的化合物，组合物和方法，例如色素性视网膜炎，Leber先天性黑素瘤，综合性视网膜变性，年龄相关性黄斑变性和Usher综合征，以及与Usher综合征相关的听力损失。
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3.发明申请PYRAZOLOPYRIDAZINES AND METHODS FOR TREATING RETINAL-DEGERATIVE DISEASES AND HEARING LOSS ASSOCIATED WITH USHER SYNDROME 有权治疗退行性疾病的紫杉醇和治疗方法与听力综合症相关的听力损失公开(公告)号：US20140121205A1
公开(公告)日：2014-05-01
申请号：US13791675
申请日：2013-03-08
Applicant: USHER III INITIATIVE
Inventor： Roland Werner Bürli , William Rameshchandra Krishna Esmieu , Christopher James Lock , Karine Fabienne Malagu , Andrew Pate Owens , William E. Harte
IPC: C07D487/04
CPC classification number: C07D487/04
Abstract: Compounds, compositions and methods for the treatment of retinal degenerative diseases, such as retinitis pigmentosa, Leber's congenital Amaurosis, Syndromic retinal degenerations, age-related macular degeneration and Usher Syndrome, and hearing loss associated with Usher Syndrome are described herein.
Abstract translation: 本文描述了用于治疗视网膜退行性疾病的化合物，组合物和方法，例如色素性视网膜炎，Leber先天性黑素瘤，综合性视网膜变性，年龄相关性黄斑变性和Usher综合征，以及与Usher综合征相关的听力损失。
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4.发明授权Pyrazolopyridazines and methods for treating retinal-degenerative diseases and hearing loss associated with usher syndrome 有权吡唑并嘧啶类和视网膜退行性疾病的治疗方法以及与发育综合征相关的听力损失公开(公告)号：US09549910B2
公开(公告)日：2017-01-24
申请号：US14980347
申请日：2015-12-28
Applicant: Usher III Initiative, Inc.
Inventor： Roland Werner Bürli , William Rameshchandra Krishna Esmieu , Christopher James Lock , Karine Fabienne Malagu , Andrew Pate Owens , William E. Harte
IPC: A61K31/165 , A61K31/40 , C07C243/28 , C07D487/04 , C07D495/04 , C07C251/86 , C07D519/00 , G01N33/50 , G01N33/68
CPC classification number: A61K31/5025 , A61K31/165 , A61K31/167 , A61K31/40 , C07C243/28 , C07C251/86 , C07C2602/08 , C07D487/04 , C07D495/04 , C07D519/00 , G01N33/502 , G01N33/6848 , G01N33/6893 , G01N2333/4703 , G01N2400/40 , G01N2500/04 , G01N2500/10
Abstract: Compounds, compositions and methods for the treatment of retinal degenerative diseases, such as retinitis pigmentosa, Leber's congenital Amaurosis, Syndromic retinal degenerations, age-related macular degeneration and Usher Syndrome, and hearing loss associated with Usher Syndrome are described herein.
Abstract translation: 本文描述了用于治疗视网膜退行性疾病的化合物，组合物和方法，例如色素性视网膜炎，Leber先天性黑素瘤，综合性视网膜变性，年龄相关性黄斑变性和Usher综合征，以及与Usher综合征相关的听力损失。
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公开(公告)号：US10307422B2
公开(公告)日：2019-06-04
申请号：US15924831
申请日：2018-03-19
Applicant: USHER III INITIATIVE, INC.
Inventor： Roland Werner Bürli , William Rameshchandra Krishna Esmieu , Christopher James Lock , Karine Fabienne Malagu , Andrew Pate Owens , William E. Harte
IPC: C07D487/04 , A61K31/5025 , A61K31/40 , C07C251/86 , C07D519/00 , G01N33/50 , G01N33/68 , A61K31/165 , A61K31/167
Abstract: Compounds, compositions and methods for the treatment of retinal degenerative diseases, such as retinitis pigmentosa, Leber's congenital Amaurosis, Syndromic retinal degenerations, age-related macular degeneration and Usher Syndrome, and hearing loss associated with Usher Syndrome are described herein.
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Patent Agency Ranking
公开(公告)号：US09925187B2
公开(公告)日：2018-03-27
申请号：US15375959
申请日：2016-12-12
Applicant: Usher III Initiative, Inc.
Inventor： Roland Werner Bürli , William Rameshchandra Krishna Esmieu , Christopher James Lock , Karine Fabienne Malagu , Andrew Pate Owens , William E. Harte
IPC: A61K31/5025 , A61K31/167
CPC classification number: A61K31/5025 , A61K31/165 , A61K31/167 , A61K31/40 , C07C243/28 , C07C251/86 , C07C2602/08 , C07D487/04 , C07D495/04 , C07D519/00 , G01N33/502 , G01N33/6848 , G01N33/6893 , G01N2333/4703 , G01N2400/40 , G01N2500/04 , G01N2500/10
Abstract: Compounds, compositions and methods for the treatment of retinal degenerative diseases, such as retinitis pigmentosa, Leber's congenital Amaurosis, Syndromic retinal degenerations, age-related macular degeneration and Usher Syndrome, and hearing loss associated with Usher Syndrome are described herein.
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7.发明授权Pyrazolopyridazines and methods for treating retinal-degenerative diseases and hearing loss associated with Usher syndrome 有权吡唑并嘧啶和治疗视网膜退行性疾病和与Usher综合征相关的听力损失的方法公开(公告)号：US09371332B2
公开(公告)日：2016-06-21
申请号：US14731535
申请日：2015-06-05
Applicant: Usher III Initiative, Inc.
Inventor： Roland Werner Bürli , William Rameschandra Krishna Esmieu , Christopher James Lock , Karine Fabienne Malagu , Andrew Pate Owens , William E Harte
IPC: C07D487/04 , A61K31/5025
CPC classification number: C07D487/04 , A61K31/5025 , C07D519/00
Abstract: Compounds, compositions and methods for the treatment of retinal degenerative diseases, such as retinitis pigmentosa, Leber's congenital Amaurosis, Syndromic retinal degenerations, age-related macular degeneration and Usher Syndrome, and hearing loss associated with Usher Syndrome are described herein.
Abstract translation: 本文描述了用于治疗视网膜退行性疾病的化合物，组合物和方法，例如色素性视网膜炎，Leber先天性黑素瘤，综合性视网膜变性，年龄相关性黄斑变性和Usher综合征，以及与Usher综合征相关的听力损失。
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8.发明授权Pyrazolopyridazines and methods for treating retinal degenerative diseases and hearing loss associated with usher syndrome 有权吡唑并嘧啶类和视网膜退行性疾病的治疗方法以及与开发综合征相关的听力损失公开(公告)号：US09260381B2
公开(公告)日：2016-02-16
申请号：US14730994
申请日：2015-06-04
Applicant: Usher III Initiative, Inc.
Inventor： Roland Werner Bürli , William Rameshchandra Krishna Esmieu , Christopher James Lock , Karine Fabienne Malagu , Andrew Pate Owens , William E Harte
IPC: C07C243/28
CPC classification number: A61K31/5025 , A61K31/165 , A61K31/167 , A61K31/40 , C07C243/28 , C07C251/86 , C07C2602/08 , C07D487/04 , C07D495/04 , C07D519/00 , G01N33/502 , G01N33/6848 , G01N33/6893 , G01N2333/4703 , G01N2400/40 , G01N2500/04 , G01N2500/10
Abstract: Compounds, compositions and methods for the treatment of retinal degenerative diseases, such as retinitis pigmentosa, Leber's congenital Amaurosis, Syndromic retinal degenerations, age-related macular degeneration and Usher Syndrome, and hearing loss associated with Usher Syndrome are described herein.
Abstract translation: 本文描述了用于治疗视网膜退行性疾病的化合物，组合物和方法，例如色素性视网膜炎，Leber先天性黑素瘤，综合性视网膜变性，年龄相关性黄斑变性和Usher综合征，以及与Usher综合征相关的听力损失。
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9.发明授权Pyrazolopyridazines and methods for treating retinal-degenerative diseases and hearing loss associated with usher syndrome 有权吡唑并嘧啶类和视网膜退行性疾病的治疗方法以及与发育综合征相关的听力损失公开(公告)号：US09227976B2
公开(公告)日：2016-01-05
申请号：US13791744
申请日：2013-03-08
Applicant: Usher III Initiative, Inc.
Inventor： Roland Werner Bürli , William Rameshchandra Krishna Esmieu , Christopher James Lock , Karine Fabienne Malagu , Andrew Pate Owens , William E Harte
IPC: C07D487/04
CPC classification number: C07D487/04 , A61K31/5025 , C07D519/00
Abstract: Compounds, compositions and methods for the treatment of retinal degenerative diseases, such as retinitis pigmentosa, Leber's congenital Amaurosis, Syndromic retinal degenerations, age-related macular degeneration and Usher Syndrome, and hearing loss associated with Usher Syndrome are described herein.
Abstract translation: 本文描述了用于治疗视网膜退行性疾病的化合物，组合物和方法，例如色素性视网膜炎，Leber先天性黑素瘤，综合性视网膜变性，年龄相关性黄斑变性和Usher综合征，以及与Usher综合征相关的听力损失。
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10.发明授权Pyrazolopyridazines and methods for treating retinal-degerative diseases and hearing loss associated with usher syndrome 有权吡唑并嘧啶和治疗视网膜萎缩性疾病的方法以及与开窍综合征相关的听力损失公开(公告)号：US08765762B2
公开(公告)日：2014-07-01
申请号：US13791675
申请日：2013-03-08
Applicant: Usher III Initiative
Inventor： Roland Werner Bürli , William Rameshchandra Krishna Esmieu , Christopher James Lock , Karine Fabienne Malagu , Andrew Pate Owens , William E. Harte
IPC: A61K31/497 , C07D231/12
CPC classification number: C07D487/04
Abstract: Compounds, compositions and methods for the treatment of retinal degenerative diseases, such as retinitis pigmentosa, Leber's congenital Amaurosis, Syndromic retinal degenerations, age-related macular degeneration and Usher Syndrome, and hearing loss associated with Usher Syndrome are described herein.
Abstract translation: 本文描述了用于治疗视网膜退行性疾病的化合物，组合物和方法，例如色素性视网膜炎，Leber先天性黑素瘤，综合性视网膜变性，年龄相关性黄斑变性和Usher综合征，以及与Usher综合征相关的听力损失。
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