公开(公告)号：US10745400B2

公开(公告)日：2020-08-18

申请号：US16353745

申请日：2019-03-14

Applicant: Vanderbilt University

Inventor： Corey R. Hopkins ,  Matthew Ritter ,  Charles C. Hong ,  Anish Vadukoot ,  Darren W. Engers ,  Craig W. Lindsley

IPC: C07D471/10 ,  A61K31/438 ,  C07D471/04 ,  A61P35/00

Abstract: Provided herein are substituted imidazo[1,2-a]pyridines useful as inhibitors of BMP signaling. The invention further provides pharmaceutical compositions of the compounds of the invention. The invention also provides medical uses of substituted imidazo[1,2-a]pyridines.

公开(公告)号：US20200054643A1

公开(公告)日：2020-02-20

申请号：US16478772

申请日：2018-01-18

Applicant: Vanderbilt University

Inventor： Corey R. Hopkins ,  Charles C. Hong ,  Craig W. Lindsley ,  Darren W. Engers

IPC: A61K31/5377 ,  A61K31/4725 ,  A61K31/437 ,  A61K31/4709 ,  A61K31/498 ,  A61K31/496 ,  A61K31/506 ,  A61K31/519 ,  A61K31/4985

Abstract: The present invention provides small molecule inhibitors of BMP signaling that are useful for treating diseases or conditions associated with BMP signaling, including cancers of the central nervous system.

公开(公告)号：US20170313701A1

公开(公告)日：2017-11-02

申请号：US15652100

申请日：2017-07-17

Applicant: Vanderbilt University

Inventor： Corey R. Hopkins ,  Charles C. Hong ,  Craig W. Lindsley ,  Darren W. Engers

IPC: C07D471/04 ,  A61K31/519 ,  A61K31/4709 ,  A61K31/5025 ,  C07D519/00 ,  C07D487/04

CPC classification number: C07D471/04 ,  A61K31/4709 ,  A61K31/5025 ,  A61K31/519 ,  C07D487/04 ,  C07D519/00

Abstract: The present invention provides small molecule inhibitors of BMP signaling. These compounds may be used to modulate cell growth, differentiation, proliferation, and apoptosis, and thus may be useful for treating diseases or conditions associated with BMP signaling, including inflammation, cardiovascular disease, hematological disease, cancer, and bone disorders, as well as for modulating cellular differentiation and/or proliferation.

公开(公告)号：US20170190717A1

公开(公告)日：2017-07-06

申请号：US15452551

申请日：2017-03-07

Applicant: Vanderbilt University

Inventor： Charles C. Hong ,  Charles H. Williams ,  Jonathan Hempel ,  TK Feaster ,  Don H. Rubin ,  Gary Sulikowski ,  Jijun Hao ,  Audrey Frist

IPC: C07D495/14 ,  A61K9/00 ,  C07D495/04 ,  A61K31/519 ,  A61K31/381 ,  C07D409/12 ,  A61K31/517 ,  C07D471/04 ,  C07D333/38 ,  A61K45/06 ,  A61K31/5377

CPC classification number: C07D495/14 ,  A61K9/0019 ,  A61K9/0078 ,  A61K31/381 ,  A61K31/517 ,  A61K31/519 ,  A61K31/5377 ,  A61K45/06 ,  C07D333/38 ,  C07D409/12 ,  C07D471/04 ,  C07D495/04 ,  A61K2300/00

Abstract: Compounds and compositions, and methods of use thereof, are provided and have utility in inhibiting hedgehog signaling and/or phosphodiesterase-4 activity.

公开(公告)号：US20190284183A1

公开(公告)日：2019-09-19

申请号：US16353745

申请日：2019-03-14

Applicant: Vanderbilt University

Inventor： Corey R. Hopkins ,  Matthew Ritter ,  Charles C. Hong ,  Anish Vadulkoot ,  Darren Engers ,  Craig W. Lindsley

IPC: C07D471/04

Abstract: Provided herein are substituted imidazo[1,2-a]pyridines useful as inhibitors of BMP signaling. The invention further provides pharmaceutical compositions of the compounds of the invention. The invention also provides medical uses of substituted imidazo[1,2-a]pyridines.

公开(公告)号：US10196392B2

公开(公告)日：2019-02-05

申请号：US15652100

申请日：2017-07-17

Applicant: Vanderbilt University

Inventor： Corey R. Hopkins ,  Charles C. Hong ,  Craig W. Lindsley ,  Darren W. Engers

IPC: A61K31/4709 ,  A61K31/5025 ,  A61K31/519 ,  C07D471/04 ,  C07D487/04 ,  C07D519/00

Abstract: The present invention provides small molecule inhibitors of BMP signaling. These compounds may be used to modulate cell growth, differentiation, proliferation, and apoptosis, and thus may be useful for treating diseases or conditions associated with BMP signaling, including inflammation, cardiovascular disease, hematological disease, cancer, and bone disorders, as well as for modulating cellular differentiation and/or proliferation.

公开(公告)号：US20190218214A1

公开(公告)日：2019-07-18

申请号：US16333201

申请日：2017-09-14

Applicant: Vanderbilt University

Inventor： Corey R. Hopkins ,  Charles C. Hong ,  Craig W. Lindsley ,  Darren W. Engers

IPC: C07D471/04 ,  C07D519/00 ,  A61P35/00

CPC classification number: C07D471/04 ,  A61P35/00 ,  C07D519/00

Abstract: Provided herein are substituted imidazo[1,2-a]pyridines useful as inhibitors of BMP signaling. The invention further provides pharmaceutical compositions of the compounds of the invention. The invention also provides medical uses of substituted imidazo [1,2-a] pyridines.

公开(公告)号：US10329304B2

公开(公告)日：2019-06-25

申请号：US15452551

申请日：2017-03-07

Applicant: Vanderbilt University

Inventor： Charles C. Hong ,  Charles H. Williams ,  Jonathan Hempel ,  T K Feaster ,  Don H. Rubin ,  Gary Sulikowski ,  Jijun Hao ,  Audrey Frist

IPC: C07D495/14 ,  C07D495/04 ,  C07D409/12 ,  C07D471/04 ,  C07D333/38 ,  A61K45/06 ,  A61K9/00 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/517 ,  A61K31/381

Abstract: Compounds and compositions, and methods of use thereof, are provided and have utility in inhibiting hedgehog signaling and/or phosphodiesterase-4 activity.

公开(公告)号：US09738636B2

公开(公告)日：2017-08-22

申请号：US14432472

申请日：2013-03-15

Applicant: Vanderbilt University

Inventor： Corey R. Hopkins ,  Charles C. Hong ,  Craig W. Lindsley ,  Darren W. Engers

IPC: C07D471/04 ,  A61K31/4709 ,  A61K31/5025 ,  A61K31/519 ,  C07D487/04 ,  C07D519/00

CPC classification number: C07D471/04 ,  A61K31/4709 ,  A61K31/5025 ,  A61K31/519 ,  C07D487/04 ,  C07D519/00

Abstract: The present invention provides small molecule inhibitors of BMP signaling. These compounds may be used to modulate cell growth, differentiation, proliferation, and apoptosis, and thus may be useful for treating diseases or conditions associated with BMP signaling, including inflammation, cardiovascular disease, hematological disease, cancer, and bone disorders, as well as for modulating cellular differentiation and/or proliferation.

公开(公告)号：US20160068525A1

公开(公告)日：2016-03-10

申请号：US14432472

申请日：2013-03-15

Applicant: VANDERBILT UNIVERSITY

Inventor： Corey R. Hopkins ,  Charles C. Hong ,  Craig W. Lindsley ,  Darren W. Engers

IPC: C07D471/04 ,  C07D519/00 ,  C07D487/04

CPC classification number: C07D471/04 ,  A61K31/4709 ,  A61K31/5025 ,  A61K31/519 ,  C07D487/04 ,  C07D519/00

Abstract: The present invention provides small molecule inhibitors of BMP signaling. These compounds may be used to modulate cell growth, differentiation, proliferation, and apoptosis, and thus may be useful for treating diseases or conditions associated with BMP signaling, including inflammation, cardiovascular disease, hematological disease, cancer, and bone disorders, as well as for modulating cellular differentiation and/or proliferation.

Abstract translation: 本发明提供BMP信号传导的小分子抑制剂。 这些化合物可用于调节细胞生长，分化，增殖和凋亡，因此可用于治疗与BMP信号相关的疾病或病症，包括炎症，心血管疾病，血液病，癌症和骨骼疾病，以及 用于调节细胞分化和/或增殖。