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    Lyase Enzymes, Nucleic Acids Encoding Them and Methods for Making and Using Them
    1.
    发明申请
    Lyase Enzymes, Nucleic Acids Encoding Them and Methods for Making and Using Them 有权
    裂解酶，编码它们的核酸及其制备和使用方法

    公开(公告)号：US20140178460A1

    公开(公告)日：2014-06-26

    申请号：US14014567

    申请日：2013-08-30

    申请人： VERENIUM CORPORATION

    发明人： David P. WEINER ,  Alexander VARVAK ,  Toby RICHARDSON ,  Mircea PODAR ,  Ellen BURKE ,  Shaun HEALEY

    IPC分类号： C12N9/88 ,  C12P7/42

    CPC分类号： C12N9/88 ,  C12P7/42 ,  C12P13/222 ,  C12P13/225 ,  C12P13/24 ,  C12Y403/01005 ,  C12Y403/01023 ,  D06M16/003

    摘要： This invention provides polypeptides having lyase activity, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. In one aspect, the invention is directed to polypeptides having ammonia lyase activity, e.g., phenylalanine ammonia lyase, tyrosine ammonia lyase and/or histidine ammonia lyase activity, including thermostable and thermotolerant activity, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides. The polypeptides of the invention can be used in a variety of pharmaceutical, agricultural and industrial contexts.

    摘要翻译： 本发明提供了具有裂解酶活性的多肽，编码这些多肽的多核苷酸，以及制备和使用这些多核苷酸和多肽的方法。 一方面，本发明涉及具有氨裂解酶活性的多肽，例如苯丙氨酸氨裂解酶，酪氨酸氨裂解酶和/或组氨酸氨裂解酶活性，包括耐热和耐热活性，以及​​编码这些酶的多核苷酸，以及制备和使用这些多核苷酸 和多肽。 本发明的多肽可用于多种药物，农业和工业环境。