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公开(公告)号:US20240150377A1
公开(公告)日:2024-05-09
申请号:US18248071
申请日:2021-10-06
发明人: Jason MCCARTNEY , Alexander Russell ABELA , Sunny ABRAHAM , Corey Don ANDERSON , Vijayalaksmi ARUMUGAM , Jaclyn CHAU , Jeremy CLEMENS , Thomas CLEVELAND , Timothy Richard COON , Timothy A. DWIGHT , Lev Tyler Dewey FANNING , Bryan A. FRIEMAN , Peter GROOTENHUIS , Anton V. GULEVICH , Sara Sabina HADIDA RUAH , Yoshihiro ISHIHARA , Haripada KHATUYA , Paul KRENITSKY , Vito MELILLO , Mark Thomas MILLER , Prasuna PARASELLI , Fabrice PIERRE , Alina SILINA , Joe A. TRAN , Johnny UY , Lino VALDEZ , Troy VICKERS , Jinglan ZHOU
IPC分类号: C07D515/08 , A61K31/404 , A61K31/47 , A61K31/529
CPC分类号: C07D515/08 , A61K31/404 , A61K31/47 , A61K31/529
摘要: This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) having core structure (I), pharmaceutical compositions containing at least one such modulator, methods of treatment of CFTR mediated diseases, including cystic fibrosis, using such modulators and pharmaceutical compositions, combination pharmaceutical compositions and combination therapies employing those modulators, and processes and intermediates for making such modulators.