公开(公告)号：US20170260146A1

公开(公告)日：2017-09-14

申请号：US15529615

申请日：2015-12-01

Applicant: VIRGINIA COMMONWEALTH UNIVERSITY

Inventor： Frank GUPTON ,  Alex MARTIN ,  Ali SIAMAKI ,  Katherine BELECKI

IPC: C07D235/20 ,  B01J35/00 ,  B01J31/22 ,  B01J31/24 ,  B01J23/44 ,  B01J21/18

CPC classification number: C07D235/20 ,  A61K31/4184 ,  B01J21/18 ,  B01J23/44 ,  B01J31/2295 ,  B01J31/2409 ,  B01J35/0006 ,  B01J2231/4211 ,  B01J2531/824 ,  B01J2531/842 ,  C07D403/04

Abstract: Methods of synthesizing the angiotensin II receptor antagonist telmisartan in high yield and purity are provided. The methods involve the coupling of two structurally distinct benzimidazole units via a Suzuki cross-coupling reaction. Methods of regioselectively synthesizing one of the benzimidazole units are also provided.