公开(公告)号：US20230407304A1

公开(公告)日：2023-12-21

申请号：US18253529

申请日：2021-11-19

Applicant: VIRGINIA COMMONWEALTH UNIVERSITY

Inventor： Zvi SCHWARTZ ,  Barbara D. BOYAN ,  Kayla M. SCOTT ,  Joshua D. COHEN

IPC: C12N15/113 ,  A61K31/7105 ,  A61P19/02

CPC classification number: C12N15/113 ,  A61K31/7105 ,  A61P19/02

Abstract: Inflammatory processes, particularly those arising from trauma or injury to the region of a bone joint, are causative of osteoarthritis (OA). A composition comprising microRNA-122, microRNA-122 mimic, and/or an inhibitor of microRNA-451 reduces or inhibits inflammatory mediators in articular chondrocytes and related cells. When administered to a subject at risk of developing OA, development of OA and/or progression of OA disease are inhibited, and cartilaginous structures are preserved in the joint. Since joint injury is associated with subsequent development of OA, the treatment is particularly suitable following an acute injury to a joint.

公开(公告)号：US20250034413A1

公开(公告)日：2025-01-30

申请号：US18716703

申请日：2022-12-06

Applicant: VIRGINIA COMMONWEALTH UNIVERSITY

Inventor： Lucas C. OLSON ,  Michael J. MCCLURE ,  Zvi SCHWARTZ ,  Tri M. NGUYEN ,  Barbara D. BOYAN

IPC: C09D11/02 ,  C12N5/077 ,  C12N9/64

Abstract: A method of decellularizing in an animal tissue includes digesting the animal tissue; treating the animal tissue with a surfactant: treating the animal tissue with at least one zwitterionic detergent to form a decellularized animal tissue; and treating the decellularized animal tissue with at least one advanced glycation end-product (AGE) inhibitor to reduce AGE crosslinking in the decellularized animal tissue. The decellularized animal tissue may be ground into a powder and dissolved in a digest solution to form a bioink composition useful for 3D printing an in vitro model of healthy or diseased tissue.