公开(公告)号：US09884836B2

公开(公告)日：2018-02-06

申请号：US15113449

申请日：2015-01-22

Applicant: VIRGINIA COMMONWEALTH UNIVERSITY

Inventor： Dwight A. Williams ,  Yan Zhang

IPC: C07D311/22 ,  C07D407/06 ,  C07D409/06

CPC classification number: C07D311/22 ,  C07D407/06 ,  C07D409/06

Abstract: A family of compounds which function as selective ligands for the serotonin receptor 2B (5-HT2B) is identified. Some of the compounds are synthetic non-natural ligands which have a relatively strong interaction with 5-HT2B compared to naturally occurring compounds (some of which are identified for the first time herein as ligands for 5-HT2B). Because the compounds, both naturally occurring and synthetically produced, function as ligands for 5-HT2B they will have application in, for example, the treatment and/or prevention of nervous system disorders such as Alzheimer's disease.

公开(公告)号：US20170029399A1

公开(公告)日：2017-02-02

申请号：US15113449

申请日：2015-01-22

Applicant: VIRGINIA COMMONWEALTH UNIVERSITY

Inventor： Dwight A. Williams ,  Yan Zhang

IPC: C07D311/22 ,  C07D409/06 ,  C07D407/06

CPC classification number: C07D311/22 ,  C07D407/06 ,  C07D409/06

Abstract: A family of compounds which function as selective ligands for the serotonin receptor 2B (5-HT2B) is identified. Some of the compounds are synthetic non-natural ligands which have a relatively strong interaction with 5-HT2B compared to naturally occurring compounds (some of which are identified for the first time herein as ligands for 5-HT2B). Because the compounds, both naturally occurring and synthetically produced, function as ligands for 5-HT2B they will have application in, for example, the treatment and/or prevention of nervous system disorders such as Alzheimer's disease.

Abstract translation: 用于血清素受体2B（5-HT2B）的选择性配体的化合物家族被鉴定。 与天然存在的化合物相比，一些化合物是与5-HT2B相对强相互作用的合成非天然配体（其中一些本文首次鉴定为5-HT2B的配体）。 因为天然存在和合成产生的化合物作为5-HT 2B的配体起作用，例如可用于治疗和/或预防神经系统疾病如阿尔茨海默氏病。