公开(公告)号：US20230310609A1

公开(公告)日：2023-10-05

申请号：US18021637

申请日：2021-08-21

Applicant: VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY

Inventor： Zerin Mahzabin Khan ,  Scott S. Verbridge ,  Timothy E. Long ,  Eli Vlaisavlijevich

IPC: A61K41/00 ,  A61K9/00 ,  A61K9/06 ,  A61P35/00 ,  A61K47/34 ,  A61L27/52 ,  A61L27/54 ,  A61L27/26

CPC classification number: A61K41/0033 ,  A61K9/0024 ,  A61K9/06 ,  A61P35/00 ,  A61K47/34 ,  A61L27/52 ,  A61L27/54 ,  A61L27/26 ,  A61L2400/06 ,  A61B2017/320069

Abstract: Described in several embodiments herein are injectable hydrogels that are capable of attracting one or more cells, in situ. In some embodiments, the cells are cancer cells, such as cancer stem cells. Also described herein are methods of using the injectable hydrogels to fill a cavity in a subject. Also described herein are methods of treating a cancer by injecting an injectable hydrogel in a cavity in a subject formed from resecting a tumor and applying an external stimulus to the injected injectable hydrogel or area proximate to the injected injectable hydrogel.