公开(公告)号：US20170159096A1

公开(公告)日：2017-06-08

申请号：US15362826

申请日：2016-11-29

申请人： VIVA Biotech (Shanghai) Ltd.

发明人： Dongming Qian ,  Jianhua Cai ,  Liang Hu ,  Ping Wang ,  Lirong Wang ,  Xiaobo Yu ,  Danjing Wang ,  Xiuhong Zeng ,  Chen Mao ,  Delin Ren

IPC分类号： C12P21/02 ,  C07K14/47

CPC分类号： C12P21/02 ,  C07K14/47 ,  C07K14/4702 ,  C07K14/705 ,  C07K19/00 ,  C07K2319/00 ,  C12N15/62 ,  C12N15/85 ,  C12N15/866

摘要： The present invention provides a protein fragment for fusion expression of ion channel protein and transport protein. The protein fragment is a Bril protein fragment or a T4L protein fragment. Also provided is a method for preparing a fusion protein by inserting a Brit protein fragment or T4L protein fragment into the N-terminal, C-terminal or intramembrane loop region of the ion channel protein and transport protein so as to improve its, in-vitro stability and crystallizability.