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公开(公告)号：US20230399642A1
公开(公告)日：2023-12-14
申请号：US18047723
申请日：2022-10-19
发明人： Jinzhao Hou , Xin Wang , Dinah Wen-Yee Sah , Pengcheng Zhou
IPC分类号： C12N15/113 , A61P25/28 , C12N15/86
CPC分类号： C12N15/113 , A61P25/28 , C12N15/86 , C12N2310/141 , C12N2330/51 , C12N2750/14143
摘要： The present invention relates to adeno-associated viral (AAV) particles encoding siRNA molecules and methods for treating Huntington's Disease (HD).
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公开(公告)号：US20220339270A1
公开(公告)日：2022-10-27
申请号：US17607141
申请日：2020-04-29
发明人： Wencheng Liu , Todd Carter , Jinzhao Hou , Yanqun Shu , Giridhar Murlidharan , Martin Goulet , Dinah Wen-Yee Sah , Steven Paul , Xiao-Qin Ren , Xin Wang , Hiu Yan Chung
摘要： The disclosure provides compositions and methods for the preparation, manufacture and therapeutic use of viral vectors, such as adeno-associated virus (AAV) particles having viral genomes encoding one or more antibodies or antibody fragments or antibody-like polypeptides, for the prevention and/or treatment of diseases and/or disorders.
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公开(公告)号：US20200155624A1
公开(公告)日：2020-05-21
申请号：US16611041
申请日：2018-05-04
发明人： Dinah Wen-Yee Sah , Fen Chen , Pengcheng Zhou , Xin Wang , Yanqun Shu , Jinzhao Hou
IPC分类号： A61K35/76 , C12N7/00 , A61P25/14 , C12N15/113 , C12N15/86
摘要： The present invention relates to adeno-associated viral (AAV) particles encoding siRNA molecules and methods for treating Huntington's Disease (HD).
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公开(公告)号：US20240131093A1
公开(公告)日：2024-04-25
申请号：US18351930
申请日：2023-07-12
发明人： Dinah Wen-Yee Sah , Fen Chen , Pengcheng Zhou , Xin Wang , Yanqun Shu , Jinzhao Hou , Jochen Deckert , Markus Hossbach
IPC分类号： A61K35/76 , A61P25/14 , C12N7/00 , C12N15/113 , C12N15/86
摘要： The present invention relates to adeno-associated viral (AAV) particles encoding siRNA molecules and methods for treating Huntington's Disease (HD).
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公开(公告)号：US20220333131A1
公开(公告)日：2022-10-20
申请号：US17561252
申请日：2021-12-23
发明人： Jinzhao Hou , Xin Wang , Pengcheng Zhou , Xiao-Qin Ren , Dinah Wen-Yee Sah
IPC分类号： C12N15/86 , C12N7/00 , C12N15/113
摘要： The present invention relates to adeno-associated viral (AAV) particles modulatory polynucleotides encoding at least one siRNA molecules and methods of use thereof.
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公开(公告)号：US20190160091A1
公开(公告)日：2019-05-30
申请号：US16302140
申请日：2017-05-18
发明人： Dinah Wen-Yee Sah , Jinzhao Hou , Pengcheng Zhou , Xin Wang , Jochen Deckert , Markus Hossbach
IPC分类号： A61K31/713 , A61P25/14 , A61K48/00 , C12N15/63 , C12N15/113 , A61K31/7105
摘要： The present invention relates to small interfering RNA (siRNA) molecules against the HTT gene, adeno-associated viral (AAV) vectors encoding siRNA molecules and methods for treating Huntington's Disease (HD) using the siRNA molecules and AAV vectors.
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公开(公告)号：US20240226203A9
公开(公告)日：2024-07-11
申请号：US18351930
申请日：2023-07-13
发明人： Dinah Wen-Yee Sah , Fen Chen , Pengcheng Zhou , Xin Wang , Yanqun Shu , Jinzhao Hou , Jochen Deckert , Markus Hossbach
IPC分类号： A61K35/76 , A61P25/14 , C12N7/00 , C12N15/113 , C12N15/86
摘要： The present invention relates to adeno-associated viral (AAV) particles encoding siRNA molecules and methods for treating Huntington's Disease (HD).
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公开(公告)号：US11752181B2
公开(公告)日：2023-09-12
申请号：US16611041
申请日：2018-05-04
发明人： Dinah Wen-Yee Sah , Fen Chen , Pengcheng Zhou , Xin Wang , Yanqun Shu , Jinzhao Hou , Jochen Deckert , Markus Hossbach
CPC分类号： A61K35/76 , A61P25/14 , C12N7/00 , C12N15/113 , C12N15/86 , A61K48/00 , C12N2310/141 , C12N2320/32 , C12N2750/14121 , C12N2750/14123 , C12N2750/14132 , C12N2750/14143
摘要： The present invention relates to adeno-associated viral (AAV) particles encoding siRNA molecules and methods for treating Huntington's Disease (HD).
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公开(公告)号：US20200377887A1
公开(公告)日：2020-12-03
申请号：US16649244
申请日：2018-09-21
发明人： Jinzhao Hou , Xin Wang , Dinah Wen-Yee Sah , Pengcheng Zhou
IPC分类号： C12N15/113 , C12N15/86 , A61P25/28
摘要： The present invention relates to adeno-associated viral (AAV) particles encoding siRNA molecules and methods for treating Huntington's Disease (HD).
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公开(公告)号：US20200270635A1
公开(公告)日：2020-08-27
申请号：US16611046
申请日：2018-05-04
发明人： Jinzhao Hou , Xin Wang , Pengcheng Zhou , Xiao-Qin Ren , Dinah Wen-Yee Sah
IPC分类号： C12N15/86 , C12N7/00 , C12N15/113
摘要： The present invention relates to adeno-associated viral (AAV) particles modulatory polynucleotides encoding at least one siRNA molecules and methods of use thereof.
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