公开(公告)号：US20060128982A1

公开(公告)日：2006-06-15

申请号：US11009946

申请日：2004-12-10

申请人： Vaddu Reddy ,  Khwaja Ishratullah ,  Penumatcha Krishnam Raju ,  Tella Babu ,  Masna Mahesh ,  Chappeta Reddy

发明人： Vaddu Reddy ,  Khwaja Ishratullah ,  Penumatcha Krishnam Raju ,  Tella Babu ,  Masna Mahesh ,  Chappeta Reddy

IPC分类号： C07C253/34

CPC分类号： C07C253/30 ,  C07C253/34 ,  C07C255/38

摘要： The present invention relates to an environmentally benign process for the preparation of (S)-α-cyano-3-phenoxybenzyl-(S)-2-(4-chlorophenyl)isovalerate from its diastereomeric mixture (RS)-α-cyano-3-phenoxybenzyl-(S)-2-(4-chlorophenyl) isovalerate.

公开(公告)号：US20070142667A1

公开(公告)日：2007-06-21

申请号：US10541344

申请日：2003-01-03

申请人： Vaddu Reddy ,  Khwaja Ishratullah ,  Penumacha Raju ,  Bhimadaka Raju ,  Attaluri Rao ,  Tella Babu

发明人： Vaddu Reddy ,  Khwaja Ishratullah ,  Penumacha Raju ,  Bhimadaka Raju ,  Attaluri Rao ,  Tella Babu

IPC分类号： C07C63/04

CPC分类号： C07C51/412 ,  C07C51/02 ,  C07C51/43 ,  C07C57/58

摘要： The present invention relates to an environmentally benign process for preparation of (+)2-(4-chlorophenyl)-3-methyl butanoic acid (+ CPA) from its racemic acid, using optically active arylamines like (−) PEA in hydrophilic/hydrophobic organic solvents like butanol, propanol etc. as aqueous mixtures, separating the desired (+) CPA salt, mother liquor by filtration and refining the (+) CPA salt in the same solvent system as used for resolution, recovering the desired acid in high optical purity by extracting with aqueous mineral acid. The mother liquor is concentrated under vacuum and extracted with aqueous mineral acid to obtain undesired (−) CPA which was recovered and recycled after racemization. The aqueous mineral acid layer thus obtained is mixed with corresponding aqueous mineral acid layer obtained from (+) CPA recovery and extracted with aqueous caustic lie solution to recover the optically active amine used for resolution. Thus the method described effectively provides a process for recovery and recycle of the undesired (−) CPA, optically active amine, besides obtaining the desired (+) CPA in high optical purity.

摘要翻译： 本发明涉及使用光学活性芳基胺如（ - ）PEA在亲水/疏水性中从其外消旋酸制备（+）2-（4-氯苯基）-3-甲基丁酸（+ CPA）的环境友好方法 有机溶剂如丁醇，丙醇等作为水性混合物，通过过滤分离所需（+）CPA盐，母液，并在与分辨率相同的溶剂系统中精制（+）CPA盐，在高光学下回收所需酸 纯度通过用无机酸水溶液萃取。 将母液在真空下浓缩并用无机酸水溶液萃取以获得不需要的（ - ）CPA，其在外消旋化后被回收和再循环。 将由此获得的无机酸水溶液与从（+）CPA回收得到的相应的无机酸水溶液混合，并用苛性碱水溶液萃取，以回收用于拆分的光学活性胺。 因此，除了获得高光学纯度的所需（+）CPA之外，所描述的方法有效地提供了不需要的（ - ）CPA光学活性胺的回收和再循环的方法。